PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30628023-10 2019 High-glucose treatment for 24 h down-regulated the protein expression of redox-specific transcription factors Nrf-2, XBP-1 and NF-kappaB, and subsequently decreased the expression of HO-1, catalase, and SOD-2. Glucose 5-12 X-box binding protein 1 Homo sapiens 117-122 25017942-3 2014 We also demonstrate that constitutive expression of Xbp1s in Pomc neurons contributes to improved hepatic insulin sensitivity and suppression of endogenous glucose production. Glucose 156-163 X-box binding protein 1 Homo sapiens 52-56 24985580-10 2014 The SNP rs2239815 in XBP1 gene was associated with 2-hour plasma glucose levels after 75 g oral glucose load (P = 0.048) in the observed population. Glucose 65-72 X-box binding protein 1 Homo sapiens 21-25 24985580-10 2014 The SNP rs2239815 in XBP1 gene was associated with 2-hour plasma glucose levels after 75 g oral glucose load (P = 0.048) in the observed population. Glucose 96-103 X-box binding protein 1 Homo sapiens 21-25 22644804-0 2012 PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1. Glucose 31-38 X-box binding protein 1 Homo sapiens 116-121 22644804-1 2012 In the present study, we investigated the effect of X-box-binding protein-1 (XBP-1) splicing on lipogenesis in high glucose-stimulated human renal proximal tubular cell line (HKC). Glucose 116-123 X-box binding protein 1 Homo sapiens 77-82 22644804-2 2012 The results revealed that high glucose promoted the splicing of XBP-1, concomitant with up-regulation of lipogenic genes including fatty acid synthase, acetyl-CoA carboxylase, adipocyte differentiation-related protein, and cellular triglyceride. Glucose 31-38 X-box binding protein 1 Homo sapiens 64-69 22644804-3 2012 Again, silence of XBP-1 with shRNA vector inhibited high glucose-caused increased lipogenesis. Glucose 57-64 X-box binding protein 1 Homo sapiens 18-23 22644804-4 2012 Furthermore, we confirmed that the inhibition of phosphotidyl inositol 3-kinase (PI3K)/Akt pathway with LY294002 or Akt shRNA vector blocked the effect of high glucose on XBP-1 splicing and cellular triglyceride. Glucose 160-167 X-box binding protein 1 Homo sapiens 171-176 22644804-5 2012 These above data suggest that spliced XBP-1 mediates high glucose-induced lipid accumulation in HKC cells and PI3K/Akt pathway may be involved in high glucose-caused XBP-1 splicing. Glucose 58-65 X-box binding protein 1 Homo sapiens 38-43 22644804-5 2012 These above data suggest that spliced XBP-1 mediates high glucose-induced lipid accumulation in HKC cells and PI3K/Akt pathway may be involved in high glucose-caused XBP-1 splicing. Glucose 151-158 X-box binding protein 1 Homo sapiens 38-43 22644804-5 2012 These above data suggest that spliced XBP-1 mediates high glucose-induced lipid accumulation in HKC cells and PI3K/Akt pathway may be involved in high glucose-caused XBP-1 splicing. Glucose 151-158 X-box binding protein 1 Homo sapiens 166-171 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Glucose 215-222 X-box binding protein 1 Homo sapiens 106-129 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Glucose 215-222 X-box binding protein 1 Homo sapiens 131-135 24670948-1 2014 Although the mammalian IRE1alpha-XBP1 branch of the cellular unfolded protein response has been implicated in glucose and lipid metabolism, the exact metabolic role of IRE1alpha signalling in vivo remains poorly understood. Glucose 110-117 X-box binding protein 1 Homo sapiens 33-37 21633399-6 2012 Furthermore, in healthy individuals, a standard 75 g oral glucose challenge produced a significant elevation in spliced XBP-1 (1.3 fold), Grp78 (2.0 fold), and calreticulin (3.5 fold) mRNA 60 min post challenge and a significant increase in Grp78 (2.0 fold), calreticulin (2.7 fold) protein levels 2 h postchallenge, relative to fasting levels. Glucose 58-65 X-box binding protein 1 Homo sapiens 120-125 19079611-4 2008 Other UPR pathways induced by glucose starvation, e.g. XBP-1, ATF4, were also found suppressed by pyrvinium. Glucose 30-37 X-box binding protein 1 Homo sapiens 55-60 17906960-8 2007 When islets were cultured for 24 h at 11.1 mmol/l glucose, there was induction of BiP and XBP-1 in type 2 diabetes islets but not in ND islets. Glucose 50-57 X-box binding protein 1 Homo sapiens 90-95 34160344-11 2021 Also, a significant positive correlation was observed between XBP1 levels and BMI, waist circumference, fasting plasma glucose and triglyceride levels (p < .05). Glucose 119-126 X-box binding protein 1 Homo sapiens 62-66 34122346-10 2021 Pathway analyses revealed that endoplasmic-reticulum (ER) stress-related genes such as HSPA5, XBP1, and MANF, involved in the unfolded protein response (UPR), were all significantly increased following low glucose (LG) exposure, which was diminished following RLG. Glucose 206-213 X-box binding protein 1 Homo sapiens 94-98 30625303-7 2019 Exocrine acinar cells exposed to high Ins or Ins+Glu concentrations (but not Glu alone) exhibited ER-stress UPR, demonstrated by significant increase of transcript and protein levels of downstream markers in the ATF6 and IRE1 transduction arms, including: sXBP1, cleaved ATF6, XBP1, CHOP, IRE1-p and caspase-12. Glucose 49-52 X-box binding protein 1 Homo sapiens 257-261 30111834-6 2018 XBP1s enhanced the expression of fibroblast growth factor 21 and, in turn, increased PPARgamma activity, translocation of GLUT4 to the cell surface, and glucose uptake rate in adipocytes. Glucose 153-160 X-box binding protein 1 Homo sapiens 0-4 30315445-7 2018 Conversely, an increase in glucose is associated to high StarD7 levels and low GRP78 expression, phospho-eIF2alpha and XBP1 splicing, although Ire1alpha remains high when cells are restored to high glucose. Glucose 27-34 X-box binding protein 1 Homo sapiens 119-123 30305738-6 2018 Mechanistically, induction of XBP1 regulated the abundance of glutamine carriers and thus limited the influx of glutamine that is necessary to sustain mitochondrial respiration in T cells under glucose-deprived conditions. Glucose 194-201 X-box binding protein 1 Homo sapiens 30-34 27481183-5 2016 In cultured PBMCs, high glucose and FFAs induced GRP78, CHOP and XBP-1 mRNA, and high glucose also induced APP, PS1 and PS2 mRNA. Glucose 24-31 X-box binding protein 1 Homo sapiens 65-70 27356931-4 2017 However, XBP1 also yields its double-edged effects, driving the transformation from excess glucose to lipid, which is a key contribution to obesity and T2DM. Glucose 91-98 X-box binding protein 1 Homo sapiens 9-13 27356931-5 2017 In this review, we highlight the vital mechanism of XBP1 in manipulating glucose and lipid metabolism involved by multiple signaling pathways. Glucose 73-80 X-box binding protein 1 Homo sapiens 52-56