PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18984744-5 2009 Similarly to Huntington"s disease patients, mice expressing the mutated human huntingtin protein also exhibit neurodegenerative changes, motor dysfunction, perturbed energy metabolism, and elevated blood glucose levels. Glucose 204-211 huntingtin Homo sapiens 78-88 19628478-4 2009 We demonstrate that mutant huntingtin impairs glucose-stimulated insulin secretion in insulin-producing beta-cells, without altering stored levels of insulin. Glucose 46-53 huntingtin Homo sapiens 27-37 19602103-5 2009 Furthermore, we expressed N-terminal huntingtin fragments with different polyglutamine lengths in an insulinoma-cell line (INS-1E) to investigate how mutant huntingtin influences glucose-stimulated insulin release in vitro. Glucose 179-186 huntingtin Homo sapiens 157-167 19602103-7 2009 However, the glucose-stimulated induction of insulin release was significantly reduced in the insulinoma-cell line expressing highly expanded huntingtin compared to cells expressing huntingtin with modestly elongated polyglutamine stretches. Glucose 13-20 huntingtin Homo sapiens 142-152 25761110-4 2015 Here, we report the effects of the specifically-neuronal human glucose transporter expression in neurons of a Drosophila model carrying the exon 1 of the human huntingtin gene with 93 glutamine repeats (HQ93). Glucose 63-70 huntingtin Homo sapiens 160-170 10516137-4 1999 In low AR-expressing cells, 20 mM glucose decreased taurine content, hTT transporter activity, and mRNA levels, and these effects were unaffected by AR inhibition (ARI). Glucose 34-41 huntingtin Homo sapiens 69-72 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 47-54 huntingtin Homo sapiens 58-61 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 47-54 huntingtin Homo sapiens 141-144 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 47-54 huntingtin Homo sapiens 141-144 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 123-130 huntingtin Homo sapiens 58-61 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 123-130 huntingtin Homo sapiens 141-144 10516137-5 1999 In these cells, the inhibitory effects of high glucose on hTT appeared to be posttranscriptionally mediated, because 20 mM glucose decreased hTT mRNA stability without affecting hTT transcriptional rate. Glucose 123-130 huntingtin Homo sapiens 141-144 10516137-6 1999 Inhibition of PKC overcame the decrease in hTT activity in high glucose-exposed cells. Glucose 64-71 huntingtin Homo sapiens 43-46 10516137-8 1999 In these cells exposed to 5 mM glucose, hTT mRNA abundance was decreased and declined further in 20 mM glucose but was corrected by ARI. Glucose 31-38 huntingtin Homo sapiens 40-43 10516137-8 1999 In these cells exposed to 5 mM glucose, hTT mRNA abundance was decreased and declined further in 20 mM glucose but was corrected by ARI. Glucose 103-110 huntingtin Homo sapiens 40-43 10516137-9 1999 In 5 mM glucose, hTT transcriptional rate was markedly decreased in high AR-expressing cells, did not decline further in 20 mM glucose, but was increased by ARI to levels above those observed in low AR-expressing cells. Glucose 8-15 huntingtin Homo sapiens 17-20 10516137-9 1999 In 5 mM glucose, hTT transcriptional rate was markedly decreased in high AR-expressing cells, did not decline further in 20 mM glucose, but was increased by ARI to levels above those observed in low AR-expressing cells. Glucose 127-134 huntingtin Homo sapiens 17-20 10516137-10 1999 Therefore, glucose rapidly and specifically decreases taurine content, hTT activity, and mRNA abundance by AR-unrelated and AR-related posttranscriptional and transcriptional mechanisms. Glucose 11-18 huntingtin Homo sapiens 71-74