PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30729133-7	2019	Prolonged exposure to high glucose and insulin enhanced cyclin D, cyclin-dependent kinase 4 (Cdk4), and Cdk2 expression and suppressed cyclin-dependent kinase inhibitors p21 and p15/16 in HBlEpC cotreated with pioglitazone and metformin.	Glucose	27-34	cyclin dependent kinase 2	Homo sapiens	104-108	
28911860-7	2017	Conversely, VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene.	Glucose	115-122	cyclin dependent kinase 2	Homo sapiens	74-99	
28911860-7	2017	Conversely, VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene.	Glucose	115-122	cyclin dependent kinase 2	Homo sapiens	101-105	
28911860-9	2017	Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.	Glucose	137-144	cyclin dependent kinase 2	Homo sapiens	15-19	
27350339-5	2016	High glucose in cardiac progenitor cells results in reduced cell viability and decreased expression of cell cycle-related molecules, including CDK2 and cyclin E. A tube formation assay revealed that hyperglycemia led to a significant decrease in the tube-forming ability of cardiac progenitor cells.	Glucose	5-12	cyclin dependent kinase 2	Homo sapiens	143-147	
21800645-4	2011	Moreover, the expression level of cyclin-dependent kinase-2 as well as cyclin A2, D3 and E2 mRNAs is significantly decreased under glucose or glutamine deprivation conditions both in control and endoplasmic reticulum-nuclei-1-deficient glioma cells.	Glucose	131-138	cyclin dependent kinase 2	Homo sapiens	34-59	
33503433-3	2021	In the absence of any changes in beta cell mass, maturity, or proliferation, genetic deletion of Cdk2 in adult beta cells enhanced insulin secretion from isolated islets and improved glucose tolerance in vivo.	Glucose	183-190	cyclin dependent kinase 2	Homo sapiens	97-101	
33503433-5	2021	In parallel with reduced beta cell recruitment, CDK2 restricts oxidative glucose metabolism while promoting glucose-dependent amplification of insulin secretion.	Glucose	73-80	cyclin dependent kinase 2	Homo sapiens	48-52	
33503433-5	2021	In parallel with reduced beta cell recruitment, CDK2 restricts oxidative glucose metabolism while promoting glucose-dependent amplification of insulin secretion.	Glucose	108-115	cyclin dependent kinase 2	Homo sapiens	48-52	
24119616-0	2013	Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells.	Glucose	178-185	cyclin dependent kinase 2	Homo sapiens	155-159	
12379472-4	2002	In MCF-7 cells, leptin and high glucose stimulated cell proliferation as demonstrated by the increases in DNA synthesis and expression of cdk2 and cyclin D1.	Glucose	32-39	cyclin dependent kinase 2	Homo sapiens	138-142