PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31406524-1 2019 BACKGROUND: Obesity is considered associated with an increase of resistin levels that plays a role in the regulation of energy and maintaining fasting blood glucose. Glucose 157-164 resistin Homo sapiens 65-73 33913390-8 2021 The multiple regression analysis (alone and in combination) showed that independently from other factors resistin correlated positively with fasting glucose (beta = 0.37; R = 0.58; R 2 = 0.23; p < 0.01) in all investigated elderly participants. Glucose 149-156 resistin Homo sapiens 105-113 33651847-8 2021 Resistin remained as a significant risk factor even after adjusting for various covariates such as age, sex, systolic blood pressure, smoking habits, alcohol consumption, medications (antihypertensive, lipid-lowering, glucose-lowering), hsCRP and leisure time physical activity. Glucose 218-225 resistin Homo sapiens 0-8 31455007-8 2019 The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic beta cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-alpha, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Glucose 31-38 resistin Homo sapiens 236-244 32762639-8 2020 RESULTS: Concentrations of human resistin in cord sera were higher in diabetic pregnancies (67 ng/ml) compared to healthy controls (50 ng/ml, P < 0.05), and correlated (r = 0.4, P = 0.002) with a measure of maternal glycemia (glucose concentration 2 h post challenge). Glucose 226-233 resistin Homo sapiens 33-41 32762639-10 2020 Secretion of resistin from cultured CBMCs was increased in response to high glucose (25 mM). Glucose 76-83 resistin Homo sapiens 13-21 32560148-7 2020 There is an inverse correlation of the change in resistin levels with post-run glucose values (r = 0.742, p < 0.001) and a positive correlation between changes in hs-CRP and energy expenditure (r = 0.782, p < 0.001). Glucose 79-86 resistin Homo sapiens 49-57 29655569-1 2018 Resistin, a previously discovered cysteine-rich adipokine known to regulate glucose metabolism, has been emerged as a mediator in inflammation and immunity. Glucose 76-83 resistin Homo sapiens 0-8 30650338-4 2019 Resistin is a small secreted protein that regulates glucose metabolism in mammalians. Glucose 52-59 resistin Homo sapiens 0-8 31235129-2 2019 Polypeptide hormones such as adiponectin and resistin play a significant role in glucose and lipids metabolism, liver and pancreas function. Glucose 81-88 resistin Homo sapiens 45-53 31235129-9 2019 Serum resistin was found to be positively correlated with BMI, waist circumference, fasting blood glucose and total cholesterol. Glucose 98-105 resistin Homo sapiens 6-14 27353463-0 2016 Resistin impairs glucose permeability in EA.hy926 cells by down-regulating GLUT1 expression. Glucose 17-24 resistin Homo sapiens 0-8 27353463-4 2016 We therefore investigated whether resistin can mediate glucose transfer across the blood-tissue barrier. Glucose 55-62 resistin Homo sapiens 34-42 27353463-6 2016 In EA.hy926 cells treated with resistin, the permeability to glucose was heavily impaired. Glucose 61-68 resistin Homo sapiens 31-39 27353463-8 2016 In addition, overexpression of GLUT1 in EA.hy926 cells was able to recover the blocking effect of resistin on glucose permeability. Glucose 110-117 resistin Homo sapiens 98-106 28064279-8 2016 CONCLUSION: The present study suggests that the G/G genotype of RETN rs1862513 could be a predictor of the reduction of HOMA-IR, insulin, fasting glucose and LDL cholesterol secondary to a hypocaloric diet in obese subjects. Glucose 146-153 resistin Homo sapiens 64-68 24526524-0 2014 MicroRNA-492 reverses high glucose-induced insulin resistance in HUVEC cells through targeting resistin. Glucose 27-34 resistin Homo sapiens 95-103 26089609-11 2015 Plasma resistin levels were well correlated with waist circumference, glucose, triglycerides, waist/hip ratio, systolic and diastolic blood pressure, high density lipoprotein, total cholesterol, serum low density lipoprotein, serum very low density lipoprotein, insulin and insulin resistance. Glucose 70-77 resistin Homo sapiens 7-15 28531388-10 2015 Resistin mRNA expression significantly correlated with changes in HbA1c and TNF-alpha and IL-6 levels, all of which are strongly associated with glucose metabolism and/or inflammation. Glucose 145-152 resistin Homo sapiens 0-8 24526524-5 2014 Our results showed that high glucose stress induced a significant decrease in miR-492 expression, with a remarkable upregulation of resistin expression. Glucose 29-36 resistin Homo sapiens 132-140 24526524-9 2014 Together, our findings indicate that miR-492 contributes to insulin resistance and endothelial dysfunction induced by high glucose, via directly downregulating resistin expression, and involving STAT3 phosphorylation, SOCS, and P-selectin activation. Glucose 123-130 resistin Homo sapiens 160-168 24512558-9 2014 Resistin levels of patients with GDM and postpartum glucose intolerance were higher than those with GDM but no postpartum glucose intolerance (p = 0.012). Glucose 52-59 resistin Homo sapiens 0-8 24512558-12 2014 In patients with GDM, second trimester resistin levels may be predictive for postpartum glucose intolerance and second trimester visfatin levels may be related with fetal biometric measurements. Glucose 88-95 resistin Homo sapiens 39-47 21251282-1 2011 BACKGROUND: Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Glucose 91-98 resistin Homo sapiens 28-36 24320036-2 2014 Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Glucose 127-134 resistin Homo sapiens 0-8 23484124-5 2013 The subsequent addition of high glucose significantly upregulated resistin and TNF- alpha mRNA and protein secretion, while it did not have any effect on IL-6 or IL-1 beta production. Glucose 32-39 resistin Homo sapiens 66-74 23729554-7 2013 RESULTS: The resistin levels were higher in obese children compared to healthy children (23.14 +- 7.35 vs. 17.1 +- 5.7 ng/mL, p<0.05), and it is positively correlated with BMI, waist circumference, systolic blood pressure, fasting insulin, HOMA-IR, IMT and high sensitive CRP (Hs-CRP), but not related to diastolic blood pressure, blood lipids and fasting glucose. Glucose 359-366 resistin Homo sapiens 13-21 19408175-2 2009 In this study, we hypothesised that serum resistin concentrations are elevated in patients with gestational diabetes mellitus (GDM) when compared with pregnant women with normal glucose tolerance (NGT) and related to proinflammatory interleukin-6 (IL-6) and other factors conferring insulin resistance. Glucose 178-185 resistin Homo sapiens 42-50 21191840-9 2010 It is concluded that resistin inhibits insulin induced glucose uptake in myocytes by downregulating the expression of GLUT4 and it has no effects on glucose oxidation and glycogen synthesis. Glucose 55-62 resistin Homo sapiens 21-29 20154025-7 2010 Both constant and intermittent high glucose significantly suppressed the expression and secretion of adiponectin, and increased expression and secretion of resistin in mature adipocytes compared to normal glucose conditions. Glucose 36-43 resistin Homo sapiens 156-164 20154025-7 2010 Both constant and intermittent high glucose significantly suppressed the expression and secretion of adiponectin, and increased expression and secretion of resistin in mature adipocytes compared to normal glucose conditions. Glucose 205-212 resistin Homo sapiens 156-164 20154025-11 2010 Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through reactive oxygen species overproduction at the mitochondrial transport chain level in adipocytes, indicating that glycemic variability has important pathological effects on the secretion of adipokines. Glucose 18-25 resistin Homo sapiens 81-89 19639497-1 2010 Our aims were to evaluate the serum adiponectin and resistin levels at fasting and after glucose load and their interaction with risk of cardiovascular disease (CVD) in adolescents with polycystic ovary syndrome (PCOS). Glucose 89-96 resistin Homo sapiens 52-60 19708984-4 2009 Resistin reduces the glucose uptake in adipose tissue and skeletal muscle cells and may be involved in insulin resistance. Glucose 21-28 resistin Homo sapiens 0-8 20154025-0 2010 Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes. Glucose 18-25 resistin Homo sapiens 81-89 20154025-3 2010 In this study, we have investigated the effect of intermittent high glucose on the expression of adiponectin and resistin, and the production of 8-hydroxydeoxyguanosine (8-OHdG) and nitrotyrosine in the adipocytes, either in the presence or in the absence of Mn(III) tetrakis(4-benzoic acid) porphyrin chloride (MnTBAP) or thenoyltrifluoroacetone (TTFA). Glucose 68-75 resistin Homo sapiens 113-121 20156767-9 2009 A positive correlation between leptin and BMI was in both overweight subgroups and a negative one between resistin and fasting glucose was in both obese subgroups. Glucose 127-134 resistin Homo sapiens 106-114 19440859-3 2009 This study investigated the effect of resistin on glucose metabolism and insulin signaling using human recombinant resistin and small interfering RNA (siRNA) against AMPKalpha2 to treat the human liver HepG2 cells. Glucose 50-57 resistin Homo sapiens 38-46 19440859-10 2009 Resistin also increases glucose production via AMPK-mediated upregulated expression of the genes encoding hepatic gluconeogenic enzymes, G6Pase, and PEPCK. Glucose 24-31 resistin Homo sapiens 0-8 19074981-11 2009 CONCLUSIONS: SNPs in the 3" region of RETN are associated with resistin levels, and one of them is also associated with glucose levels, although replication is needed. Glucose 120-127 resistin Homo sapiens 38-42 18446452-6 2008 Overexpression of human resistin impaired significantly insulin-stimulated glucose uptake and glycogen synthesis in HepG2 cells. Glucose 75-82 resistin Homo sapiens 24-32 18410529-0 2009 Resistin modulates glucose uptake and glucose transporter-1 (GLUT-1) expression in trophoblast cells. Glucose 19-26 resistin Homo sapiens 0-8 18410529-2 2009 Here, we examine the effect of resistin on glucose uptake in human trophoblast cells and we demonstrate that transplacental glucose transport is mediated by glucose transporter (GLUT)-1. Glucose 43-50 resistin Homo sapiens 31-39 18410529-2 2009 Here, we examine the effect of resistin on glucose uptake in human trophoblast cells and we demonstrate that transplacental glucose transport is mediated by glucose transporter (GLUT)-1. Glucose 124-131 resistin Homo sapiens 31-39 18410529-7 2009 Our data demonstrate a direct effect of resistin on normal cytotrophoblastic and on BeWo cells: resistin modulates glucose uptake, GLUT-1 messenger ribonucleic acid (mRNA) and protein expression in placental cells. Glucose 115-122 resistin Homo sapiens 96-104 18410529-11 2009 High resistin levels (50-100 ng/ml) seem able to affect glucose-uptake, presumably by decreasing the cell surface glucose transporter. Glucose 56-63 resistin Homo sapiens 5-13 19545363-3 2009 Resistin is a hormone mainly derived from macrophages in humans and from adipose tissue in rodents, which regulates glucose metabolism and insulin sensitivity. Glucose 116-123 resistin Homo sapiens 0-8 18328349-6 2008 Significant positive correlation was revealed between blood resistin concentration and each of the analyzed anthropometric parameter and with fasting glucose, low-density lipoprotein cholesterol, and CRP, whereas negative relation was observed between resistin and high-density lipoprotein cholesterol. Glucose 150-157 resistin Homo sapiens 60-68 18230823-8 2008 RESULTS: Resistin levels were lower in GDM women than in pregnant women with normal glucose tolerance (NGT) (4.32+/-1.56 vs 9.30+/-1.32 ng/ml, P<0.001), and experienced a further decrease after parturition (4.24+/-1.56 vs 3.11+/-1.63 ng/ml, P=0.003). Glucose 84-91 resistin Homo sapiens 9-17 16814296-1 2007 OBJECTIVE: Resistin, an adipocyte and macrophage derived cytokine, causes insulin resistance and glucose intolerance. Glucose 97-104 resistin Homo sapiens 11-19 19125180-1 2008 Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. Glucose 66-73 resistin Homo sapiens 0-8 17365928-11 2007 Glucose load during CAPD may be an important factor in increased in leptin, resistin, triglycerides, and total cholesterol levels in CAPD patients. Glucose 0-7 resistin Homo sapiens 76-84 16608899-8 2006 Plasma resistin concentration was associated positively with leukocytes (P < 0.001), highly sensitive C-reactive protein (P = 0.009), and IGF binding protein 1 (P < 0.001), but not with plasma insulin or glucose levels in analysis of covariance after adjustments for age, sex, and body mass index. Glucose 210-217 resistin Homo sapiens 7-15 17194639-2 2006 Here, we investigated the effect of resistin on glucose tolerance in adult human hepatocytes (L-02 cells). Glucose 48-55 resistin Homo sapiens 36-44 17194639-3 2006 In this study, resistin cDNA was transfected into L-02 cells, and glucose concentration and glucokinase activity were determined subsequently. Glucose 66-73 resistin Homo sapiens 15-23 17194639-4 2006 The data indicated resistin impaired, insulin-stimulated glucose utilization, which implied liver was a target tissue of resistin. Glucose 57-64 resistin Homo sapiens 121-129 17194639-8 2006 Moreover, resistin lowered mRNA levels of IRS-2 while stimulating SOCS-3 expression, which suggests it impairs glucose tolerance by blocking the insulin signal transduction pathway. Glucose 111-118 resistin Homo sapiens 10-18 16756630-0 2006 Leptin and resistin levels and their relationships with glucose metabolism in children with chronic renal insufficiency and undergoing dialysis. Glucose 56-63 resistin Homo sapiens 11-19 16531754-2 2006 Whilst current studies appear to re-affirm the role of resistin on glucose homeostasis in rodent systems, we are still unravelling the functionality of resistin in human biology in respect to glucose metabolism and insulin signalling. Glucose 67-74 resistin Homo sapiens 55-63 16669997-0 2006 Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians. Glucose 50-57 resistin Homo sapiens 38-46 16586545-10 2006 Conversely, plasma resistin correlated positively with BMI, blood glucose, triglyceride and insulin resistance index (respectively, r=0.40, P<0.05; r=0.52, P<0.05; r=0.46, P<0.01; r=0.27, P<0.05), and negatively correlated with insulin sensitive index (r=-0.32, P<0.05). Glucose 66-73 resistin Homo sapiens 19-27 16549046-3 2006 Insulin, glucose, many cytokines and anti-diabetic thiazolidinediones are regulators of resistin gene expression. Glucose 9-16 resistin Homo sapiens 88-96 16367888-7 2006 In the absence of insulin, however, resistin increased glucose uptake dose-dependently (e.g., 1.75-fold at 5 microm, p < 0.001) via a mitogen-activated protein kinase-dependent pathway. Glucose 55-62 resistin Homo sapiens 36-44 16367888-8 2006 CONCLUSIONS: These results demonstrate that various glucose-lowering therapies and oleic acid reduce resistin gene expression in isolated adipocytes, and that resistin impairs insulin-stimulated glucose uptake in skeletal muscle-derived cells. Glucose 52-59 resistin Homo sapiens 101-109 16367888-8 2006 CONCLUSIONS: These results demonstrate that various glucose-lowering therapies and oleic acid reduce resistin gene expression in isolated adipocytes, and that resistin impairs insulin-stimulated glucose uptake in skeletal muscle-derived cells. Glucose 195-202 resistin Homo sapiens 159-167 16189200-9 2005 A high circulating resistin level at term gestation could be advantageous to the infant by promoting hepatic glucose production and preventing hypoglycemia after birth. Glucose 109-116 resistin Homo sapiens 19-27 16586545-11 2006 CONCLUSION: Plasma adiponectin and resistin are associated with the disorder of metabolism of glucose and lipid in diabetes. Glucose 94-101 resistin Homo sapiens 35-43 16961271-9 2006 Pearson analysis revealed that resistin protein was correlated with BMI (r = 0.42), fasting insulin concentration (r = 0.38), IRI (r = 0.34), BF % (r = 0.43) and fasting glucose (r = 0.39), but not with blood pressure, CHOL, TG, HDL-C and LDL-C. Glucose 170-177 resistin Homo sapiens 31-39 15741250-4 2005 Resistin concentration decreased significantly after rosiglitazone (12.17 +/- 1.15 ng/ml to 10.23 +/- 1.05 ng/ml; P = 0.02), in conjunction with significant increases in adiponectin- (P < 0.001) and insulin- stimulated glucose disposal (P = 0.004). Glucose 222-229 resistin Homo sapiens 0-8 15864531-11 2005 Mithramycin A, an inhibitor of DNA binding of Sp1, reduced the effect of high glucose on transcription induction of the resistin gene in adipocytes. Glucose 78-85 resistin Homo sapiens 120-128 14510864-0 2003 Serum resistin level in essential hypertension patients with different glucose tolerance. Glucose 71-78 resistin Homo sapiens 6-14 15754730-0 2004 Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study. Glucose 90-97 resistin Homo sapiens 6-14 15754730-10 2004 These results suggest that in men, the human resistin gene is associated with reduced amount of visceral obesity and lower insulin secretory responses to a glucose load. Glucose 156-163 resistin Homo sapiens 45-53 14671216-11 2003 Our in vitro studies demonstrated a small, but significant, reduction in glucose uptake with human recombinant resistin in differentiated preadipocytes. Glucose 73-80 resistin Homo sapiens 111-119 14671216-14 2003 Our in vitro studies suggest a modest effect of resistin in reducing glucose uptake, and suppression of resistin expression may contribute to the insulin-sensitizing and glucose-lowering actions of the thiazolidinediones. Glucose 69-76 resistin Homo sapiens 48-56 14671216-14 2003 Our in vitro studies suggest a modest effect of resistin in reducing glucose uptake, and suppression of resistin expression may contribute to the insulin-sensitizing and glucose-lowering actions of the thiazolidinediones. Glucose 170-177 resistin Homo sapiens 104-112 14510864-1 2003 AIMS: To investigate resistin concentrations in patients with essential hypertension and different glucose tolerance and the relationship between serum resistin level and blood glucose. Glucose 99-106 resistin Homo sapiens 21-29 14510864-1 2003 AIMS: To investigate resistin concentrations in patients with essential hypertension and different glucose tolerance and the relationship between serum resistin level and blood glucose. Glucose 177-184 resistin Homo sapiens 152-160 12667367-0 2002 [The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure]. Glucose 82-89 resistin Homo sapiens 38-46 14521723-9 2003 CONCLUSION: The serum resistin level of patients with type 2 diabetes is reduced rather than increased in fasting status and 2 hours after glucose taking. Glucose 139-146 resistin Homo sapiens 22-30 12829623-3 2003 The adipocyte secreted hormone resistin has been proposed as a link between the adipocyte and insulin resistance by inhibition of insulin-stimulated glucose uptake and/or blocking adipocyte differentiation. Glucose 149-156 resistin Homo sapiens 31-39