PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16904639-4 2006 Using INS-1 model beta-cell line, we show that the expression of K(ATP) channel subunits, Kir6.2 and SUR1, is high at low glucose, but declines sharply when the ambient glucose concentration exceeds 5mM. Glucose 169-176 ATP binding cassette subfamily C member 8 Rattus norvegicus 101-105 17889836-2 2007 Glucose-excited neurons in hindbrain dorsal vagal complex (DVC) monitor both glucose and lactate, and express both the glucose sensor, glucokinase (GK), and the SUR1 subunit of the plasma membrane energy transducer, K(ATP). Glucose 0-7 ATP binding cassette subfamily C member 8 Rattus norvegicus 161-165 16904639-4 2006 Using INS-1 model beta-cell line, we show that the expression of K(ATP) channel subunits, Kir6.2 and SUR1, is high at low glucose, but declines sharply when the ambient glucose concentration exceeds 5mM. Glucose 122-129 ATP binding cassette subfamily C member 8 Rattus norvegicus 101-105 17311891-2 2007 Channels comprised of Kir6.2 and SUR1 subunits function in subpopulations of mediobasal hypothalamic (MBH) neurons as an essential component of a glucose-sensing mechanism in these cells, wherein uptake and metabolism of glucose leads to increase in intracellular ATP/ADP, closure of the channels, and increase in neuronal excitability. Glucose 146-153 ATP binding cassette subfamily C member 8 Rattus norvegicus 33-37 17311891-2 2007 Channels comprised of Kir6.2 and SUR1 subunits function in subpopulations of mediobasal hypothalamic (MBH) neurons as an essential component of a glucose-sensing mechanism in these cells, wherein uptake and metabolism of glucose leads to increase in intracellular ATP/ADP, closure of the channels, and increase in neuronal excitability. Glucose 221-228 ATP binding cassette subfamily C member 8 Rattus norvegicus 33-37 15166124-1 2004 The ATP-sensitive K+ (KATP) channel, composed of Kir6.2 and sulfonylurea receptor (SUR1), in pancreatic beta-cells is believed to serve as a metabolic sensor regulating insulin secretion according to glucose levels. Glucose 200-207 ATP binding cassette subfamily C member 8 Rattus norvegicus 83-87 9439807-1 1997 Select brain neurons increase their firing rate when ambient glucose levels rise, possibly via a neuronal ATP-sensitive K+ (KATP) channel and its associated sulfonylurea receptor (SUR). Glucose 61-68 ATP binding cassette subfamily C member 8 Rattus norvegicus 157-178 10050011-0 1999 Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. Glucose 0-7 ATP binding cassette subfamily C member 8 Rattus norvegicus 109-113 10050011-13 1999 Reverse transcription followed by the polymerase chain reaction using cytoplasm from single glucose-receptive neurones demonstrated the expression of the ATP-sensitive potassium (KATP) channel subunits Kir6.1 and SUR1 but not Kir6.2 or SUR2. Glucose 92-99 ATP binding cassette subfamily C member 8 Rattus norvegicus 213-217 12877797-8 2003 Exposure of islets to 2 nmol/L leptin induced a significant increase of SUR1 transcription levels by 71% (P < 0.01) at 11.1 mmol/L glucose and by 56% (P < 0.05) at 16.7 mmol/L glucose concentration. Glucose 134-141 ATP binding cassette subfamily C member 8 Rattus norvegicus 72-76 12877797-8 2003 Exposure of islets to 2 nmol/L leptin induced a significant increase of SUR1 transcription levels by 71% (P < 0.01) at 11.1 mmol/L glucose and by 56% (P < 0.05) at 16.7 mmol/L glucose concentration. Glucose 182-189 ATP binding cassette subfamily C member 8 Rattus norvegicus 72-76 11145575-6 2001 The cognate K(ATP) channel subunit SUR1 showed similar down-regulation at high glucose concentration. Glucose 79-86 ATP binding cassette subfamily C member 8 Rattus norvegicus 35-39 10525661-1 1999 AIMS/HYPOTHESIS: A sulphonylurea receptor, SUR1, and an inward rectifier potassium channel, Kir6.2, reconstitute the ATP-sensitive K(+) channel that mediates glucose-induced insulin secretion in pancreatic beta cells. Glucose 158-165 ATP binding cassette subfamily C member 8 Rattus norvegicus 43-47 9439807-1 1997 Select brain neurons increase their firing rate when ambient glucose levels rise, possibly via a neuronal ATP-sensitive K+ (KATP) channel and its associated sulfonylurea receptor (SUR). Glucose 61-68 ATP binding cassette subfamily C member 8 Rattus norvegicus 180-183 9439807-11 1997 Thus, glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR. Glucose 6-13 ATP binding cassette subfamily C member 8 Rattus norvegicus 153-156 9439807-11 1997 Thus, glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR. Glucose 39-46 ATP binding cassette subfamily C member 8 Rattus norvegicus 153-156 26697721-9 2016 Finally, treatment of INS-1 cells with glucose and Dz overnight reduced high affinity sulfonylurea receptor (SUR1) trafficking to the plasma membrane vs glucose alone, consistent with insulin increasing KATP conductance by altering channel number. Glucose 39-46 ATP binding cassette subfamily C member 8 Rattus norvegicus 109-113 30616503-0 2019 aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model. Glucose 24-31 ATP binding cassette subfamily C member 8 Rattus norvegicus 50-73 30616503-1 2019 BACKGROUND: Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Glucose 72-79 ATP binding cassette subfamily C member 8 Rattus norvegicus 12-35 30616503-1 2019 BACKGROUND: Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Glucose 72-79 ATP binding cassette subfamily C member 8 Rattus norvegicus 37-41 30616503-2 2019 Here, we sought to investigate the glucose metabolism characteristics of SUR1-/- rats. Glucose 35-42 ATP binding cassette subfamily C member 8 Rattus norvegicus 73-77 30616503-8 2019 Upon SUR1 gene knockout, the rats showed a peculiar plasma glucose profile. Glucose 59-66 ATP binding cassette subfamily C member 8 Rattus norvegicus 5-9 30616503-9 2019 During IPGTT, plasma glucose levels were significantly elevated in SUR1-/- rats at 15 min, which could be explained by SUR1 mainly working in the first phase of insulin secretion. Glucose 21-28 ATP binding cassette subfamily C member 8 Rattus norvegicus 67-71 30616503-9 2019 During IPGTT, plasma glucose levels were significantly elevated in SUR1-/- rats at 15 min, which could be explained by SUR1 mainly working in the first phase of insulin secretion. Glucose 21-28 ATP binding cassette subfamily C member 8 Rattus norvegicus 119-123 23793715-1 2013 AIMS/HYPOTHESIS: Acute systemic delivery of the sulfonylurea receptor (SUR)-1-specific ATP-sensitive K(+) channel (K(ATP)) opener, NN414, has been reported to amplify glucose counter-regulatory responses (CRRs) in rats exposed to hypoglycaemia. Glucose 167-174 ATP binding cassette subfamily C member 8 Rattus norvegicus 48-77 18776135-8 2008 CONCLUSIONS: These studies demonstrate in a variety of rodent models that systemic delivery of Kir6.2/SUR-1-selective KCOs enhance the glucose counterregulatory response to insulin-induced hypoglycemia. Glucose 135-142 ATP binding cassette subfamily C member 8 Rattus norvegicus 102-107