PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17103462-13 2007 CONCLUSIONS: The present study shows that administration of the C-peptide fragment EVARQ has similar effects on GFR and blood glucose levels as the intact C-peptide molecule, suggesting at least one active site within this region. Glucose 126-133 insulin 2 Rattus norvegicus 64-73 18773939-3 2008 Plasma glucose lowering effect accompanying with the increase of plasma insulin and C-peptide were obtained in pentobarbital anesthetized Wistar rats 60min after an intravenous (i.v.) Glucose 7-14 insulin 2 Rattus norvegicus 84-93 18439098-10 2008 In response to glucose, Pdx1+ + BTC+ MSCs released insulin and C-peptide. Glucose 15-22 insulin 2 Rattus norvegicus 63-72 7564270-9 1995 The effect of high glucose on mesangial cell actin was reversed by returning the cells to normal glucose for 2 days, stimulation with insulin 2 micrograms/ml, or with a protein kinase C inhibitor. Glucose 19-26 insulin 2 Rattus norvegicus 134-143 16762503-8 2006 Both the plasma glucose lowering action and the raised plasma levels of insulin and C-peptide induced by Hon-Chi were also inhibited by 4-diphenylacetoxy-N-methylpiperdine methiodide (4-DAMP), but not affected by the ganglionic nicotinic antagonist, pentolinium or hexamethonium, indicating the mediation of muscarinic M(3) receptors. Glucose 16-23 insulin 2 Rattus norvegicus 84-93 16386764-8 2006 Insulin and C-peptide release in response to glucose for the slow thawed islets were lower than those of the control and in the fast thawed islets they were similar to that of the control. Glucose 45-52 insulin 2 Rattus norvegicus 12-21 10078552-8 1999 The insulin and C-peptide responses to the rise in plasma glucose from basal to 13 mmol/l were lower in OLE (336 +/- 72 pmol/l and 1.2 +/- 0.1 nmol/l, P < 0.01 and P < 0.05, respectively) than in CONT (552 +/- 54 and 1.9 +/- 0.1) rats, but they were not different between CONT and INT rats (648 +/- 150 and 2.0 +/- 0.4). Glucose 58-65 insulin 2 Rattus norvegicus 16-25 10078552-9 1999 The insulin and C-peptide responses to the rise in plasma glucose from 13 to 22 mmol/l were lower in both INT (1,188 +/- 204 pmol/l and 3.0 +/- 0.3 nmol/l, P < 0.01 and P < 0.001) and OLE (432 +/- 60 and 1.7 +/- 0.2, P < 0.001 vs. CONT or INT) rats than in CONT rats (1,662 +/- 174 and 5.0 +/- 0.6). Glucose 58-65 insulin 2 Rattus norvegicus 16-25 8910330-6 1996 Des-(27-31)C-peptide is also secreted in a glucose-sensitive manner from the perfused adult rat pancreas, accounting for approximately 10% of total C-peptide immunoreactivity secreted. Glucose 43-50 insulin 2 Rattus norvegicus 11-20 8910330-6 1996 Des-(27-31)C-peptide is also secreted in a glucose-sensitive manner from the perfused adult rat pancreas, accounting for approximately 10% of total C-peptide immunoreactivity secreted. Glucose 43-50 insulin 2 Rattus norvegicus 148-157 8800366-0 1996 Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats. Glucose 49-56 insulin 2 Rattus norvegicus 10-19 8800366-1 1996 Recent studies suggest that C-peptide stimulates glucose transport in isolated skeletal muscle. Glucose 49-56 insulin 2 Rattus norvegicus 28-37 8800366-6 1996 The metabolic clearance rate of glucose (MCR) for the diabetic rats receiving C-peptide (12.0 +/- 1.0 mL kg-1 min-1) was significantly (P < 0.01) higher than that in the diabetic rats given saline (6.3 +/- 0.7 mL kg-1 min-1) or a randomly scrambled C-peptide (7.8 +/- 1.3 mL kg-1 min-1) at low-dose insulin infusion but not at the high-dose insulin infusion. Glucose 32-39 insulin 2 Rattus norvegicus 78-87 8800366-6 1996 The metabolic clearance rate of glucose (MCR) for the diabetic rats receiving C-peptide (12.0 +/- 1.0 mL kg-1 min-1) was significantly (P < 0.01) higher than that in the diabetic rats given saline (6.3 +/- 0.7 mL kg-1 min-1) or a randomly scrambled C-peptide (7.8 +/- 1.3 mL kg-1 min-1) at low-dose insulin infusion but not at the high-dose insulin infusion. Glucose 32-39 insulin 2 Rattus norvegicus 252-261 8800366-8 1996 These results thus demonstrate that C-peptide has the capacity to increase glucose utilization in STZ-induced diabetic rats. Glucose 75-82 insulin 2 Rattus norvegicus 36-45 3878779-0 1985 C-peptide-like material in rat brain: response to fasting and glucose ingestion. Glucose 62-69 insulin 2 Rattus norvegicus 0-9 1370150-15 1992 Although INS-2 cells have not been fully characterized, their insulin content was similar to that of INS-1 cells and they also remain partially sensitive to glucose as a secretagogue. Glucose 157-164 insulin 2 Rattus norvegicus 9-14 3310024-3 1987 Phenylpropanolamine (15, 25 and 35 mg/kg IP) significantly reduced food intake in a dose-related fashion at the 1 hr and 3 hr time intervals in the food deprivation-, insulin- and 2-deoxy glucose-induced hyperphagic models. Glucose 188-195 insulin 2 Rattus norvegicus 167-181 3878779-4 1985 Fasting for 72 h resulted in a decrease and oral glucose administration (0.75-1.5 g given in form of 25% water solution 30 min before sacrifice) was followed by an increase of C-peptide-like immunoreactivity in both plasma and hypothalamus. Glucose 49-56 insulin 2 Rattus norvegicus 176-185 33901627-0 2021 C-peptide ameliorates high glucose-induced podocyte dysfunction through the regulation of the Notch and TGF-beta signaling pathways. Glucose 27-34 insulin 2 Rattus norvegicus 0-9 6139319-2 1983 Infusion of rat C-peptide (500 micrograms X h-1 X kg-1) diminished glucose induced increase of plasma insulin by 56% (15.2 +/- 0.9 versus 6.6 +/- 0.6 ng/ml, p less than 0.01, mean +/- SEM). Glucose 67-74 insulin 2 Rattus norvegicus 16-25 349994-3 1977 However, the insulin response to 16.7 mM glucose decreased in the presence of exogenous rat insulin or synthetic rat C-peptide, showing a biphasic pattern of glucose-induced insulin release. Glucose 41-48 insulin 2 Rattus norvegicus 117-126 349994-3 1977 However, the insulin response to 16.7 mM glucose decreased in the presence of exogenous rat insulin or synthetic rat C-peptide, showing a biphasic pattern of glucose-induced insulin release. Glucose 158-165 insulin 2 Rattus norvegicus 117-126 349994-4 1977 When rat insulin or C-peptide were added at 20 min and removed at 40 min while the isolated pancreas was exposed to a 60-min glucose infusion (16.7 mM), glucose-induced insulin secretion decreased during the infusion of rat insulin or C-peptide. Glucose 125-132 insulin 2 Rattus norvegicus 20-29 349994-4 1977 When rat insulin or C-peptide were added at 20 min and removed at 40 min while the isolated pancreas was exposed to a 60-min glucose infusion (16.7 mM), glucose-induced insulin secretion decreased during the infusion of rat insulin or C-peptide. Glucose 125-132 insulin 2 Rattus norvegicus 235-244 349994-5 1977 The present study clearly showed that exogenous rat insulin and synthetic rat C-peptide 1 and 2 inhibited glucose-induced insulin secretion. Glucose 106-113 insulin 2 Rattus norvegicus 78-87 33901627-3 2021 The aim of this study was to investigate the effect of C-peptide on high glucose-induced podocyte dysfunction. Glucose 73-80 insulin 2 Rattus norvegicus 55-64 33901627-6 2021 Based on this background, we determined that the application of C-peptide significantly prevented high glucose-induced podocyte injury by increasing the expression of nephrin and synaptopodin. Glucose 103-110 insulin 2 Rattus norvegicus 64-73 33901627-7 2021 Meanwhile, C-peptide suppressed high glucose-induced epithelial-mesenchymal transition (EMT) and renal fibrosis via decreasing the expression of snail, vimentin, alpha-smooth muscle actin (alpha-SMA) and connective tissue growth factor (CTGF). Glucose 37-44 insulin 2 Rattus norvegicus 11-20 33901627-8 2021 Moreover, the Notch and transforming growth factor-beta (TGF-beta) signaling pathways were activated by high glucose, and treatment with C-peptide down-regulated the expression of the Notch signaling molecules Notch 1 and Jagged 1 and the TGF-beta signaling molecule TGF-beta1. Glucose 109-116 insulin 2 Rattus norvegicus 137-146 27806092-14 2016 This glucose-lowering effect was more pronounced in ZDF rats, where portal alphaMG infusion increased insulin, C-peptide and GIP levels compared to saline infusions. Glucose 5-12 insulin 2 Rattus norvegicus 111-120 32704568-1 2020 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Glucose 130-137 insulin 2 Rattus norvegicus 6-15 32704568-4 2020 Materials and methods: We exposed INS1 beta cells to palmitic acid and C-peptide in the setting of increasing glucose concentration and tested for changes in parameters of stress and death. Glucose 110-117 insulin 2 Rattus norvegicus 71-80 32704568-7 2020 Results: C-peptide protects INS1 beta cells from the combined effect of palmitic acid and glucose by reducing peroxisomal H2O2 to baseline levels and increasing expression of catalase. Glucose 90-97 insulin 2 Rattus norvegicus 9-18 30817059-8 2019 This finding indicates that C-peptide remains in the abdominal cavity when intraperitoneally transplanted islets release C-peptide via high glucose stimulation. Glucose 140-147 insulin 2 Rattus norvegicus 28-37 30817059-8 2019 This finding indicates that C-peptide remains in the abdominal cavity when intraperitoneally transplanted islets release C-peptide via high glucose stimulation. Glucose 140-147 insulin 2 Rattus norvegicus 121-130 28101192-0 2016 C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells. Glucose 80-87 insulin 2 Rattus norvegicus 0-9 23772634-7 2014 Glucose stimulation increased C-peptide secretion in these cells. Glucose 0-7 insulin 2 Rattus norvegicus 30-39 26671180-8 2016 We asked whether transgene activity was responsive to glucose as shown previously for the ins2 gene. Glucose 54-61 insulin 2 Rattus norvegicus 90-94 26468390-4 2016 Significant improvements in postprandial hyperglycemia and plasma c-peptide level were observed when glucose was administered orally post-surgery. Glucose 101-108 insulin 2 Rattus norvegicus 66-75 25684188-5 2015 A sustained supplementation of C-peptide at a physiological level could ameliorate urinary albumin, independent of blood glucose control. Glucose 121-128 insulin 2 Rattus norvegicus 31-40 22811482-1 2012 Previous studies have demonstrated that renoprotective effects of C-peptide in experimental models of diabetes-induced renal disease may be mediated via lowering blood glucose. Glucose 168-175 insulin 2 Rattus norvegicus 66-75 22990990-1 2013 We have previously reported that C-peptide modulates insulin-mediated inhibition of lipolysis and glucose consumption but has no significant effects per se on adipose tissue of normal rats. Glucose 98-105 insulin 2 Rattus norvegicus 33-42 19756305-5 2009 Glucose accumulation in diabetic ERYs, measured by scintillation counting of (14)C-labeled glucose, increased by 35.8 +/- 1.3% in the presence of the Zn(2+)-activated C-peptide, a value significantly lower than results obtained from control ERYs (64.3 +/- 5.1%). Glucose 91-98 insulin 2 Rattus norvegicus 167-176 21553365-2 2011 Although effects of CP on muscle glucose consumption are relatively well studied, its effects on adipose tissue, a key organ involved in metabolism, are not well known. Glucose 33-40 insulin 2 Rattus norvegicus 20-22 21106770-8 2010 Moreover, C-peptide (300 nM) completely inhibited the glucose-induced increase of the collagen IV mRNA expression and protein concentration in mesangial cells cultured in 30 mM glucose medium. Glucose 54-61 insulin 2 Rattus norvegicus 10-19 22545626-9 2012 C-peptide release was increased after glucose challenge in vitro. Glucose 38-45 insulin 2 Rattus norvegicus 0-9 21106770-8 2010 Moreover, C-peptide (300 nM) completely inhibited the glucose-induced increase of the collagen IV mRNA expression and protein concentration in mesangial cells cultured in 30 mM glucose medium. Glucose 177-184 insulin 2 Rattus norvegicus 10-19 20702574-4 2010 The precision study and the analysis of controls confirm that the validated ELISAs for rat C-peptide and proinsulin would be useful for further studies on the effects of preculture in different glucose concentrations. Glucose 194-201 insulin 2 Rattus norvegicus 91-100 20702574-5 2010 The higher the glucose concentration used during the 72-h culture period of rat islets, the higher insulin, C-peptide and proinsulin values were obtained in a subsequent short-term glucose-challenge experiment. Glucose 15-22 insulin 2 Rattus norvegicus 108-117 20702574-5 2010 The higher the glucose concentration used during the 72-h culture period of rat islets, the higher insulin, C-peptide and proinsulin values were obtained in a subsequent short-term glucose-challenge experiment. Glucose 181-188 insulin 2 Rattus norvegicus 108-117 20702574-7 2010 We also observed a nonequimolar, glucose-dependent secretion and content of rat insulin over rat C-peptide after culture at 11.1 and 28 mM glucose. Glucose 33-40 insulin 2 Rattus norvegicus 97-106 20702574-7 2010 We also observed a nonequimolar, glucose-dependent secretion and content of rat insulin over rat C-peptide after culture at 11.1 and 28 mM glucose. Glucose 139-146 insulin 2 Rattus norvegicus 97-106