PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15890364-2 2005 Genetic analyses of Grr1 mutants have implicated Grr1 in glucose repression, specifically with regard to expression of the SUC2 transcript. Glucose 57-64 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 20-24 6323921-2 1984 The mutant allele, termed grr-1 for glucose repression-resistant, is characterized by insensitivity to glucose repression for the cytoplasmic enzymes invertase, maltase, and galactokinase, as well as the mitochondrial enzyme cytochrome c oxidase. Glucose 36-43 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 26-31 6323921-2 1984 The mutant allele, termed grr-1 for glucose repression-resistant, is characterized by insensitivity to glucose repression for the cytoplasmic enzymes invertase, maltase, and galactokinase, as well as the mitochondrial enzyme cytochrome c oxidase. Glucose 103-110 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 26-31 19684065-10 2009 Results from experiments with single gene deletion mutants partially impaired in glucose repression (hxk2, grr1) indicated that the rate of glucose uptake correlates with this increase in TCA cycle flux. Glucose 81-88 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 107-111 17366522-0 2007 Delayed accumulation of the yeast G1 cyclins Cln1 and Cln2 and the F-box protein Grr1 in response to glucose. Glucose 101-108 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 81-85 17366522-5 2007 We report that the F-box protein Grr1 also accumulates at higher levels in the presence of glucose, and that the response to glucose follows a delayed pattern strikingly similar to that described for Cln1 and Cln2. Glucose 91-98 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 33-37 17366522-5 2007 We report that the F-box protein Grr1 also accumulates at higher levels in the presence of glucose, and that the response to glucose follows a delayed pattern strikingly similar to that described for Cln1 and Cln2. Glucose 125-132 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 33-37 17366522-7 2007 While we found that Grr1 is more stable in cells growing with glucose, we show that the delayed responses to glucose occur independently: Grr1 accumulates in the absence of the cyclins, and vice versa. Glucose 62-69 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 20-24 17366522-7 2007 While we found that Grr1 is more stable in cells growing with glucose, we show that the delayed responses to glucose occur independently: Grr1 accumulates in the absence of the cyclins, and vice versa. Glucose 109-116 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 138-142 17366522-9 2007 Glucose is known to strengthen the interaction of Grr1 with Skp1 in the SCF complex. Glucose 0-7 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 50-54 17366522-10 2007 We hypothesize that glucose could promote the accumulation of Grr1 and its assembly into a SCF complex as a feedback regulation that helps compensate for higher cyclins levels. Glucose 20-27 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 62-66 16112084-2 2005 We previously reported that the F-box protein Grr1p is one of the proteins involved in the transmission of glucose-generated signal for proteolysis of the galactose transporter Gal2p and fructose-1,6-bisphosphatase. Glucose 107-114 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 46-51 16112084-3 2005 In this study, we show that the other components of SCF(Grr1), including Skp1, Rbx1p, and the ubiquitin-conjugating enzyme Cdc34, are also necessary for glucose-induced Gal2p degradation. Glucose 153-160 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 56-60 16112084-4 2005 This suggests that transmission of the glucose signal involves an SCF(Grr1)-mediated ubiquitination step. Glucose 39-46 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 70-74 21653827-10 2011 The Ssy5 phosphoacceptor motif resembles the Yck1/2- and Grr1-dependent degrons of regulators in the Snf3/Rgt2 glucose-sensing pathway. Glucose 111-118 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 57-61 17586499-2 2007 Mth1 and Std1 are degraded via the Yck1/2 kinase-SCF(Grr1)-26S proteasome pathway triggered by the glucose sensors. Glucose 99-106 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 53-57 16400179-4 2006 We present evidence that glucose-induced degradation of Std1 via the SCF(Grr1) ubiquitin-protein ligase and the 26S proteasome is obscured by feedback regulation of STD1 expression. Glucose 25-32 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 73-77 15890364-2 2005 Genetic analyses of Grr1 mutants have implicated Grr1 in glucose repression, specifically with regard to expression of the SUC2 transcript. Glucose 57-64 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 49-53 15556081-0 2004 Elucidation of the role of Grr1p in glucose sensing by Saccharomyces cerevisiae through genome-wide transcription analysis. Glucose 36-43 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 27-32 15849787-3 2005 We also demonstrate that 14-3-3 proteins, in complex with Reg1, a regulatory subunit of Glc7 protein phosphatase, interact physically with Grr1 (a component of the SCF-Grr1 ubiquitination complex), a key player in the process of HXT1 induction by glucose. Glucose 247-254 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 139-143 15849787-3 2005 We also demonstrate that 14-3-3 proteins, in complex with Reg1, a regulatory subunit of Glc7 protein phosphatase, interact physically with Grr1 (a component of the SCF-Grr1 ubiquitination complex), a key player in the process of HXT1 induction by glucose. Glucose 247-254 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 168-172 15601864-3 2005 The effects of glucose on Sic1p levels and DNA replication required Grr1p, a component of the SCF(Grr1p) ubiquitin ligase. Glucose 15-22 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 68-73 15601864-3 2005 The effects of glucose on Sic1p levels and DNA replication required Grr1p, a component of the SCF(Grr1p) ubiquitin ligase. Glucose 15-22 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 98-103 15601864-4 2005 Sic1p is negatively regulated by Ime2p kinase, and several observations indicate that glucose inhibits meiotic DNA replication through SCF(Grr1p)-mediated destruction of this kinase. Glucose 86-93 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 139-144 15611869-1 2005 The F-box protein Grr1p is involved in cell cycle regulation, glucose repression and transcriptional induction of the amino acid permease (AAP) gene AGP1. Glucose 62-69 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 18-23 15611869-8 2005 Increased expression of glucose-repressed genes in the grr1Delta strain may be explained by the reduced expression of the hexose transporter genes HXT1, HXT2, HXT3 and HXT4 and a subsequent lowering of the glucose uptake; and the effect of GRR1 deletion on general carbon metabolism may therefore be indirect. Glucose 24-31 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 240-244 15611869-8 2005 Increased expression of glucose-repressed genes in the grr1Delta strain may be explained by the reduced expression of the hexose transporter genes HXT1, HXT2, HXT3 and HXT4 and a subsequent lowering of the glucose uptake; and the effect of GRR1 deletion on general carbon metabolism may therefore be indirect. Glucose 206-213 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 240-244 15556081-1 2004 The role of Grr1p in glucose sensing in Saccharomyces cerevisiae was elucidated through genome-wide transcription analysis. Glucose 21-28 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 12-17 15282800-6 2004 Different glucose derepressed strains investigated employed are the disruption mutants reg1, hxk2, grr1, mig1 and mig1mig2 and the reference strain CEN.PK113-7D. Glucose 10-17 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 99-103 15456873-2 2004 In addition to its role in degradation of Gic2 and the CDK targets Cln1 and Cln2, Grr1 is also required for induction of glucose- and amino acid-regulated genes. Glucose 121-128 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 82-86 15456873-3 2004 Induction of HXT genes by glucose requires the Grr1-dependent degradation of Mth1. Glucose 26-33 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 47-51 15282800-7 2004 Principal components analysis of the summed fractional labelling data show that deleting the genes HXK2 and GRR1 results in similar phenotype at the fluxome level, with a partial alleviation of glucose repression on the respiratory metabolism. Glucose 194-201 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 108-112 12925759-0 2003 Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promoters. Glucose 45-52 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 15014083-1 2004 Expression of the HXT1 gene, which encodes a low affinity glucose transporter in Saccharomyces cerevisiae, is regulated positively in response to glucose by the general glucose induction pathway, involving the Snf3/Rgt2 membrane glucose sensors, the SCF-Grr1 ubiquitination complex and the Rgt1 transcription factor. Glucose 58-65 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 254-258 15014083-1 2004 Expression of the HXT1 gene, which encodes a low affinity glucose transporter in Saccharomyces cerevisiae, is regulated positively in response to glucose by the general glucose induction pathway, involving the Snf3/Rgt2 membrane glucose sensors, the SCF-Grr1 ubiquitination complex and the Rgt1 transcription factor. Glucose 146-153 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 254-258 15014083-1 2004 Expression of the HXT1 gene, which encodes a low affinity glucose transporter in Saccharomyces cerevisiae, is regulated positively in response to glucose by the general glucose induction pathway, involving the Snf3/Rgt2 membrane glucose sensors, the SCF-Grr1 ubiquitination complex and the Rgt1 transcription factor. Glucose 146-153 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 254-258 12925759-1 2003 In budding yeast, HXT genes encoding hexose permeases are induced by glucose via a mechanism in which the F box protein Grr1 antagonizes activity of the transcriptional repressor Rgt1. Glucose 69-76 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 120-124 12925759-8 2003 Consistent with that proposal, Mth1 is rapidly eliminated in response to glucose via a mechanism that requires Grr1. Glucose 73-80 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 111-115 12925759-9 2003 Based upon these data, we propose that glucose acts via Grr1 to promote the degradation of Mth1. Glucose 39-46 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 56-60 9819356-2 1998 Grr1, which is required for degradation of G1 cyclins Cln1 and Cln2 as well as for regulation of glucose repression, is an F-box protein and interacts with Skp1 through the F-box motif. Glucose 97-104 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 12527758-7 2003 Furthermore, Rgt1 lacks the glucose-mediated phosphorylation in the snf3 rgt2 and grr1 mutants, which are defective in glucose induction of HXT gene expression. Glucose 28-35 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 82-86 12527758-7 2003 Furthermore, Rgt1 lacks the glucose-mediated phosphorylation in the snf3 rgt2 and grr1 mutants, which are defective in glucose induction of HXT gene expression. Glucose 119-126 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 82-86 12008900-4 2002 One of them codes for AtGRH1, a new F-box protein that shows similarity to GRR1, a yeast protein involved in glucose repression. Glucose 109-116 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 75-79 12420140-6 2002 HAP2 is required to sporulate in any carbon source, whereas GRR1 is required for glucose repression of sporulation. Glucose 81-88 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 11773046-6 2002 In addition, Grr1p and Reg1p were found to play a role in transduction of the glucose signal for glucose-induced proteolysis of Gal2p and FBPase. Glucose 78-85 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 13-18 11773046-6 2002 In addition, Grr1p and Reg1p were found to play a role in transduction of the glucose signal for glucose-induced proteolysis of Gal2p and FBPase. Glucose 97-104 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 13-18 9891035-7 1999 Induction of AGP1 by amino acids also requires Grr1p, the F-box protein of the SCFGrr1 ubiquitin-protein ligase complex also required for transduction of the glucose signal generated by the Snf3p and Rgt2p glucose sensors. Glucose 158-165 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 47-52 9891035-7 1999 Induction of AGP1 by amino acids also requires Grr1p, the F-box protein of the SCFGrr1 ubiquitin-protein ligase complex also required for transduction of the glucose signal generated by the Snf3p and Rgt2p glucose sensors. Glucose 206-213 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 47-52 9491072-5 1998 One of them was found to be defective in GRR1, which is involved not only in glucose repression but also in G1 cyclin destabilization. Glucose 77-84 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 41-45 9566913-8 1998 This effect is absent in glucose repression mutants cat80/grr1, hex2/reg1, and cid1/glc7. Glucose 25-32 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 58-62 8887670-8 1996 Grr1p, a component of the glucose signaling pathway, is required both for inactivation of Rgt1p repressor function by low levels of glucose and for conversion of Rgt1p into an activator at high levels of glucose. Glucose 26-33 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-5 8887670-5 1996 Glucose alters Rgt1p function through a pathway that includes two glucose sensors, Snf3p and Rgt2p, and Grr1p. Glucose 0-7 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 104-109 8948096-7 1996 Both SKS1 and its DDSE can additionally suppress the growth defects of grr1 mutants, which are also impaired in high affinity glucose transport. Glucose 126-133 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 71-75 8889516-1 1996 An ssu2 mutation in Saccharomyces cerevisiae, previously shown to cause sulfite sensitivity, was found to be allelic to GRR1, a gene previously implicated in glucose repression. Glucose 158-165 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 3-7 8889516-1 1996 An ssu2 mutation in Saccharomyces cerevisiae, previously shown to cause sulfite sensitivity, was found to be allelic to GRR1, a gene previously implicated in glucose repression. Glucose 158-165 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 120-124 8889516-2 1996 The suppressor rgt1, which suppresses the growth defects of grr1 strains on glucose, did not fully suppress the sensitivity on glucose or nonglucose carbon sources, indicating that it is not strictly linked to a defect in glucose metabolism. Glucose 76-83 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 9312022-0 1997 Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. Glucose 108-115 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 9312022-1 1997 Grr1 protein of the yeast Saccharomyces cerevisiae is a central component of a glucose signal transduction mechanism responsible for glucose-induced gene expression. Glucose 79-86 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 9312022-1 1997 Grr1 protein of the yeast Saccharomyces cerevisiae is a central component of a glucose signal transduction mechanism responsible for glucose-induced gene expression. Glucose 133-140 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 9312022-5 1997 Thus, Grr1 may regulate the cell cycle and glucose-induced gene expression via ubiquitin-mediated protein degradation. Glucose 43-50 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 6-10 9312022-6 1997 Consistent with this idea, Skp1, like Grr1, was found to be required for glucose-induced HXT gene expression. Glucose 73-80 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 38-42 9312022-8 1997 The Grr1-Skp1 interaction is enhanced by high levels of glucose. Glucose 56-63 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 4-8 9045801-4 1997 We analyzed the effects of mutations in the MIG1, TUP1, and GRR1 genes on glucose repression of PRB1 and found that mutations in each partially alleviate glucose repression. Glucose 74-81 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 9045801-4 1997 We analyzed the effects of mutations in the MIG1, TUP1, and GRR1 genes on glucose repression of PRB1 and found that mutations in each partially alleviate glucose repression. Glucose 154-161 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 8887670-8 1996 Grr1p, a component of the glucose signaling pathway, is required both for inactivation of Rgt1p repressor function by low levels of glucose and for conversion of Rgt1p into an activator at high levels of glucose. Glucose 132-139 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-5 8887670-8 1996 Grr1p, a component of the glucose signaling pathway, is required both for inactivation of Rgt1p repressor function by low levels of glucose and for conversion of Rgt1p into an activator at high levels of glucose. Glucose 132-139 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-5 8887670-9 1996 Thus, signals generated by two different glucose sensors act through Grr1p to determine Rgt1p function. Glucose 41-48 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 69-74 7862149-5 1995 GRR1 seems to encode a positive regulator of HXT expression, since grr1 mutants are defective in glucose induction of all four HXT genes. Glucose 97-104 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 7862149-5 1995 GRR1 seems to encode a positive regulator of HXT expression, since grr1 mutants are defective in glucose induction of all four HXT genes. Glucose 97-104 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 67-71 7862149-6 1995 Mutations in RGT1 suppress the defect in HXT expression caused by grr1 mutations, leading us to propose that glucose induces HXT expression by activating Grr1p, which inhibits the function of the Rgt1p repressor. Glucose 109-116 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 66-70 7862149-6 1995 Mutations in RGT1 suppress the defect in HXT expression caused by grr1 mutations, leading us to propose that glucose induces HXT expression by activating Grr1p, which inhibits the function of the Rgt1p repressor. Glucose 109-116 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 154-159 8013904-1 1994 We selected and analyzed extragenic suppressors of mutations in four genes--GRR1, REG1, GAL82 and GAL83-required for glucose repression of the GAL genes in the yeast Saccharomyces cerevisiae. Glucose 117-124 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 76-80 7883165-4 1995 Surprisingly, one group of mutants was found to be allelic to GRR1, a gene previously described to be involved in glucose uptake, glucose repression, and divalent cation transport. Glucose 114-121 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 62-66 7883165-4 1995 Surprisingly, one group of mutants was found to be allelic to GRR1, a gene previously described to be involved in glucose uptake, glucose repression, and divalent cation transport. Glucose 130-137 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 62-66 7982576-5 1994 Multicopy HXT4 and DDSEs in the HXT1, HXT2, HXT3 and HXT4 promoters were found to restore growth to snf3 and grr1 strains on low glucose media. Glucose 129-136 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 109-113 8013904-3 1994 Tests of the ability of each suppressor to cross-suppress mutations in the other glucose repression genes revealed two groups of mutually cross-suppressed genes: (1) REG1, GAL82 and GAL83 and (2) GRR1. Glucose 81-88 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 196-200 8013904-7 1994 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose 105-112 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 133-138 8013904-7 1994 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose 157-164 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 133-138 8013904-7 1994 These results, together with what was previously known about these genes, lead us to propose a model for glucose repression in which Grr1p acts early in the glucose repression pathway, perhaps affecting the generation of the signal for glucose repression. Glucose 157-164 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 133-138 8013905-0 1994 Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Glucose 32-39 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 90-94 8013905-6 1994 We suggest that GRR1 affects the glucose sensing process and that the association between transport and regulation may reflect the involvement of a transporter in glucose sensing. Glucose 33-40 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 16-20 8013905-1 1994 The GRR1 gene of Saccharomyces cerevisiae affects glucose repression, cell morphology, divalent cation transport and other processes. Glucose 50-57 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 4-8 8013905-2 1994 We present a kinetic analysis showing that the grr1 mutant is also defective in high affinity glucose transport. Glucose 94-101 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 47-51 8013905-6 1994 We suggest that GRR1 affects the glucose sensing process and that the association between transport and regulation may reflect the involvement of a transporter in glucose sensing. Glucose 163-170 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 16-20 8013905-3 1994 In combination with a mutation in SNF3, a member of the glucose transporter gene family, grr1 strikingly impairs growth on glucose. Glucose 56-63 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 89-93 8013905-4 1994 These findings suggest that GRR1 and SNF3 affect glucose transport by distinct pathways. Glucose 49-56 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 28-32 1922034-0 1991 GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Glucose 49-56 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 0-4 8455597-0 1993 The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae. Glucose 30-37 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 4-8 8455597-4 1993 The rate of glucose-dependent transport of cobalt into cells was reduced in strains that carry mutations in the COT2 gene. Glucose 12-19 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 112-116 8455597-7 1993 The sequence of the COT2 gene shows that it is identical to GRR1, which encodes a protein required for glucose repression. Glucose 103-110 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 20-24 8455597-7 1993 The sequence of the COT2 gene shows that it is identical to GRR1, which encodes a protein required for glucose repression. Glucose 103-110 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 8455597-8 1993 The glucose dependence of the transport defect implies that cot2 mutations affect the link between glucose metabolism and divalent cation active transport. Glucose 4-11 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 60-64 1752413-5 1991 Finally, one of the mutants carries a grr1 allele that converts SUC2 from a glucose-inducible gene. Glucose 76-83 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 38-42 1922034-2 1991 The GRR1 gene appears to be of central importance to the glucose repression mechanism, because mutations in GRR1 result in a pleiotropic loss of glucose repression (R. Bailey and A. Woodword, Mol. Glucose 57-64 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 4-8 1922034-2 1991 The GRR1 gene appears to be of central importance to the glucose repression mechanism, because mutations in GRR1 result in a pleiotropic loss of glucose repression (R. Bailey and A. Woodword, Mol. Glucose 57-64 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 108-112 1922034-6 1991 Surprisingly, grr1 mutations convert SUC2, normally a glucose-repressed gene, into a glucose-induced gene. Glucose 54-61 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 14-18 1922034-6 1991 Surprisingly, grr1 mutations convert SUC2, normally a glucose-repressed gene, into a glucose-induced gene. Glucose 85-92 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 14-18 1922034-10 1991 The combined genetic and molecular data are consistent with the idea that GRR1 protein is a primary response element in the glucose repression pathway and is required for the generation or interpretation of the signal that induces glucose repression. Glucose 124-131 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 74-78 1922034-10 1991 The combined genetic and molecular data are consistent with the idea that GRR1 protein is a primary response element in the glucose repression pathway and is required for the generation or interpretation of the signal that induces glucose repression. Glucose 231-238 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 74-78 2201902-8 1990 To identify the gene products that confer repression upon UASG and URSG, we have analyzed glucose repression mutants and found that the GAL83, REG1, GRR1, and SSN6 genes are required for repression mediated by both UASG and URSG. Glucose 90-97 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 149-153 7925377-2 1994 In a screen, designed for the selection of mutants with reduced glycolytic flux we obtained isolates which were shown by complementation of the cloned wild-type gene to be allelic to the glucose repression mutants grr1/cat80/cot2 previously described. Glucose 187-194 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 214-218 7925377-2 1994 In a screen, designed for the selection of mutants with reduced glycolytic flux we obtained isolates which were shown by complementation of the cloned wild-type gene to be allelic to the glucose repression mutants grr1/cat80/cot2 previously described. Glucose 187-194 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 219-224 7925377-3 1994 We demonstrate that the grr1 lesion lead to a concentration-dependent decrease in glycolytic flux on glucose. Glucose 101-108 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 24-28 7925377-8 1994 We suggest that Grr1, a putative cytoplasmic protein, has a central function in the sensing of nutritional conditions for a variety of unrelated substances, and that relief from glucose repression may be a corollary of this defect in sensing. Glucose 178-185 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 16-20 35119506-6 2022 To demonstrate the wider potential of the assay, we applied this assay to two other systems: the effect of Grr1 on glucose repression of GAL1 transcription in yeast and the effect of rpsL on stop-codon translational readthrough in Escherichia coli. Glucose 115-122 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 107-111