PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28125064-0 2017 Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes. oxophenylarsine 0-18 PML nuclear body scaffold Homo sapiens 61-64 28125064-3 2017 In the present study, we for the first time establish whether organic arsenic species phenylarsine oxide (PAO) could induce the mutant PML-IV (A216V) protein solubility changes and degradation. oxophenylarsine 86-104 PML nuclear body scaffold Homo sapiens 135-138 28125064-3 2017 In the present study, we for the first time establish whether organic arsenic species phenylarsine oxide (PAO) could induce the mutant PML-IV (A216V) protein solubility changes and degradation. oxophenylarsine 106-109 PML nuclear body scaffold Homo sapiens 135-138 28125064-4 2017 Here, three different PML protein variants (i.e., PML-IV, PML-V and mutant PML-A216V) were overexpressed in HEK293T cells and then exposed to PAO in time- and dose-dependent manners. oxophenylarsine 142-145 PML nuclear body scaffold Homo sapiens 22-25 28125064-5 2017 Interestingly, PAO is found to have potential effect on induction of mutant PML-IV (A216V) protein solubility changes and degradation, but no appreciable effects were found following exposure to high concentrations of iAsIII, dimethylarsinous acid (DMAIII) and adriamycin (doxorubicin), even though they cause cell death. oxophenylarsine 15-18 PML nuclear body scaffold Homo sapiens 76-79 28125064-6 2017 Our current data strongly indicate that PAO has good effects on the mutant PML protein solubility changes, and it may be helpful for improving the therapeutic strategies for arsenic-resistant APL treatments in the near future. oxophenylarsine 40-43 PML nuclear body scaffold Homo sapiens 75-78