PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10660607-0 2000 Vicinal dithiol-binding agent, phenylarsine oxide, inhibits inducible nitric-oxide synthase gene expression at a step of nuclear factor-kappaB DNA binding in hepatocytes. oxophenylarsine 31-49 nitric oxide synthase 2 Rattus norvegicus 60-91 10660607-3 2000 In the present study, we found that vicinal dithiol-binding agent, phenylarsine oxide (PAO), inhibited the induction of iNOS protein and mRNA as well as the release of nitrite (nitric oxide metabolite) into the culture medium. oxophenylarsine 67-85 nitric oxide synthase 2 Rattus norvegicus 120-124 10660607-3 2000 In the present study, we found that vicinal dithiol-binding agent, phenylarsine oxide (PAO), inhibited the induction of iNOS protein and mRNA as well as the release of nitrite (nitric oxide metabolite) into the culture medium. oxophenylarsine 87-90 nitric oxide synthase 2 Rattus norvegicus 120-124 10660607-8 2000 These results indicate that PAO inhibits iNOS gene expression at a step of NF-kappaB binding to DNA by modifying its vicinal dithiol moiety, which may play a crucial role for the iNOS regulation in hepatocytes. oxophenylarsine 28-31 nitric oxide synthase 2 Rattus norvegicus 41-45 10660607-8 2000 These results indicate that PAO inhibits iNOS gene expression at a step of NF-kappaB binding to DNA by modifying its vicinal dithiol moiety, which may play a crucial role for the iNOS regulation in hepatocytes. oxophenylarsine 28-31 nitric oxide synthase 2 Rattus norvegicus 179-183