PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24352565-0	2014	Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets.	oxophenylarsine	95-113	RAS guanyl releasing protein 2	Homo sapiens	18-29	
24352565-4	2014	PAO also prevented the Ca2+ ionophore-induced Rap1 activation and platelet aggregation, which are dependent on CalDAG-GEFI.	oxophenylarsine	0-3	RAS guanyl releasing protein 2	Homo sapiens	111-122	
24352565-5	2014	In the biotin-streptavidin pull-down assay, CalDAG-GEFI was efficiently pull-downed by streptavidin beads from the lysates of biotin-conjugated PAO-treated platelets, suggesting that PAO binds to intracellular CalDAG-GEFI with high affinity.	oxophenylarsine	144-147	RAS guanyl releasing protein 2	Homo sapiens	44-55	
24352565-5	2014	In the biotin-streptavidin pull-down assay, CalDAG-GEFI was efficiently pull-downed by streptavidin beads from the lysates of biotin-conjugated PAO-treated platelets, suggesting that PAO binds to intracellular CalDAG-GEFI with high affinity.	oxophenylarsine	144-147	RAS guanyl releasing protein 2	Homo sapiens	210-221	
24352565-5	2014	In the biotin-streptavidin pull-down assay, CalDAG-GEFI was efficiently pull-downed by streptavidin beads from the lysates of biotin-conjugated PAO-treated platelets, suggesting that PAO binds to intracellular CalDAG-GEFI with high affinity.	oxophenylarsine	183-186	RAS guanyl releasing protein 2	Homo sapiens	44-55	
24352565-5	2014	In the biotin-streptavidin pull-down assay, CalDAG-GEFI was efficiently pull-downed by streptavidin beads from the lysates of biotin-conjugated PAO-treated platelets, suggesting that PAO binds to intracellular CalDAG-GEFI with high affinity.	oxophenylarsine	183-186	RAS guanyl releasing protein 2	Homo sapiens	210-221	
24352565-8	2014	In a purified recombinant protein system, PAO directly inhibited CalDAG-GEFI-stimulated GTP binding to Rap1.	oxophenylarsine	42-45	RAS guanyl releasing protein 2	Homo sapiens	65-76	
24352565-9	2014	Using CalDAG-GEFI and Rap1-overexpressed human embryonic kidney 293T cells, we further confirmed that PAO abolished Ca2+-mediated Rap1 activation.	oxophenylarsine	102-105	RAS guanyl releasing protein 2	Homo sapiens	6-17	
24352565-10	2014	Taken together, these results have demonstrated that CalDAG-GEFI is one of the targets of action of PAO, and propose an important role of vicinal cysteines for the functions of CalDAG-GEFI.	oxophenylarsine	100-103	RAS guanyl releasing protein 2	Homo sapiens	53-64