PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18566755-8 2008 Cytochalasin D treatment immediately following release of gels inhibited contraction in a dose-dependent manner as well as prevented upregulation of MMP-1, MMP-3, and alpha2 integrin mRNA levels in contracting gels. Cytochalasin D 0-14 matrix metallopeptidase 1 Homo sapiens 149-154 11691580-5 2001 In RCG, a significant up-regulation of these MMPs was also observed although to a lower extent than in CD-treated monolayers. Cytochalasin D 103-105 matrix metallopeptidase 1 Homo sapiens 45-49 11691580-8 2001 The CD-induced up-regulation of gene expression was largely repressed by blocking protein synthesis by cycloheximide for all the MMPs, by inhibiting the tyrosine-kinases of the src family by herbimycin A for all MMPs, except MMP-2, and by inhibiting the TPA-inducible PKC isoforms by bisindoyl maleimide for all MMPs, except MMP-14. Cytochalasin D 4-6 matrix metallopeptidase 1 Homo sapiens 129-133 11691580-8 2001 The CD-induced up-regulation of gene expression was largely repressed by blocking protein synthesis by cycloheximide for all the MMPs, by inhibiting the tyrosine-kinases of the src family by herbimycin A for all MMPs, except MMP-2, and by inhibiting the TPA-inducible PKC isoforms by bisindoyl maleimide for all MMPs, except MMP-14. Cytochalasin D 4-6 matrix metallopeptidase 1 Homo sapiens 212-216 11691580-8 2001 The CD-induced up-regulation of gene expression was largely repressed by blocking protein synthesis by cycloheximide for all the MMPs, by inhibiting the tyrosine-kinases of the src family by herbimycin A for all MMPs, except MMP-2, and by inhibiting the TPA-inducible PKC isoforms by bisindoyl maleimide for all MMPs, except MMP-14. Cytochalasin D 4-6 matrix metallopeptidase 1 Homo sapiens 212-216 9722543-1 1998 The integrin-mediated stress relaxation as it occurs in a retracting three-dimensional collagen gel (RCG) is accompanied by a large up-regulation of the interstitial collagenase, matrix metalloproteinase 1 ((MMP-1), EC 3.4.24.7), regulated notably by interleukin-1 (IL-1), phorbol esters, and cytoskeleton-disrupting drugs as cytochalasin D (CD). Cytochalasin D 326-340 matrix metallopeptidase 1 Homo sapiens 208-213 9722543-1 1998 The integrin-mediated stress relaxation as it occurs in a retracting three-dimensional collagen gel (RCG) is accompanied by a large up-regulation of the interstitial collagenase, matrix metalloproteinase 1 ((MMP-1), EC 3.4.24.7), regulated notably by interleukin-1 (IL-1), phorbol esters, and cytoskeleton-disrupting drugs as cytochalasin D (CD). Cytochalasin D 342-344 matrix metallopeptidase 1 Homo sapiens 208-213 9722543-5 1998 The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors. Cytochalasin D 41-43 matrix metallopeptidase 1 Homo sapiens 74-79 9722543-6 1998 In contrast bisindoylmaleimide, at a concentration (5 microM) that inhibits the TPA-induced protein kinase C activity, suppressed the CD-induced MMP-1 expression but did not or barely altered that induced in RCG or by IL-1. Cytochalasin D 134-136 matrix metallopeptidase 1 Homo sapiens 145-150 9722543-7 1998 None of the other tested inhibitors of a variety of signaling pathways including those used by integrins was able to suppress the RCG or CD-induced MMP-1. Cytochalasin D 137-139 matrix metallopeptidase 1 Homo sapiens 148-153