PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23109336-7	2012	Moreover, the combination of the lack of ubiquitination at Lys-501 and the disruption of the di-leucine motif (BACE1LLAA/KR) produces additive effects on BACE1 stabilization and defective internalization.	di-leucine	93-103	beta-secretase 1	Homo sapiens	111-116	
16033761-4	2005	The carboxyl terminus of BACE contains a di-leucine-based signal for sorting of transmembrane proteins to endosomes and lysosomes.	di-leucine	41-51	beta-secretase 1	Homo sapiens	25-29	
16033761-5	2005	In this study, we set out to determine whether BACE is degraded by the lysosomal pathway and whether the di-leucine motif is necessary for targeting BACE to the lysosomes.	di-leucine	105-115	beta-secretase 1	Homo sapiens	149-153	
23109336-9	2012	Our studies have elucidated a differential role for the di-leucine motif and ubiquitination at Lys-501 in BACE1 endocytosis, trafficking, and degradation and suggest the involvement of multiple adaptor molecules.	di-leucine	56-66	beta-secretase 1	Homo sapiens	106-111