PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17497735-0 2008 Tricalcium phosphate delayed release formulation for oral delivery of insulin: a proof-of-concept study. tricalcium phosphate 0-20 insulin Homo sapiens 70-77 17497735-4 2008 Therefore, an attempt has been made to load insulin in tricalcium phosphate (TCP) microspheres and coat with pH sensitive polymer of methacrylate derivative, and to study the stability and conformational variations of loaded insulin, and finally the biological activity of the formulation in diabetic rats. tricalcium phosphate 55-75 insulin Homo sapiens 44-51 17497735-4 2008 Therefore, an attempt has been made to load insulin in tricalcium phosphate (TCP) microspheres and coat with pH sensitive polymer of methacrylate derivative, and to study the stability and conformational variations of loaded insulin, and finally the biological activity of the formulation in diabetic rats. tricalcium phosphate 77-80 insulin Homo sapiens 44-51 17497735-11 2008 It has been established from this preliminary study that insulin loaded in to TCP microspheres is highly compatible with no degradation or loss of biological activity of loaded insulin. tricalcium phosphate 78-81 insulin Homo sapiens 57-64 17497735-12 2008 The TCP microsphere based delayed release formulation of insulin has effected a decrease in elevated glucose level in induced diabetic rats, establishing its feasibility towards the development of a noninvasive delivery device. tricalcium phosphate 4-7 insulin Homo sapiens 57-64