PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30622742-4 2019 Surprisingly, the PAA:nanoalum adjuvant elicited a robust TH1 immune response characterized by antigen-specific CD4+ T cells expressing IFN-gamma and TNF, as well as high IgG2 titers, whereas the parent Alhydrogel and PAA elicited modest TH2 immunity characterized by IgG1 antibodies. carbopol 940 18-21 negative elongation factor complex member C/D Homo sapiens 58-61 33427044-4 2021 In this article, using the Respiratory Syncytial Virus (RSV) nanoparticulate prefusion F model antigen developed by Sanofi, we demonstrate in the macaque model that the polyacrylate (PAA)-based adjuvant SPA09 is well tolerated and increases vaccine antigen-specific humoral immunity (sustained neutralizing antibodies, memory B cells and mucosal immunity) and elicits strong TH1-type responses (based on IFNgamma and IL-2 ELISpots) in a dose-dependent manner. carbopol 940 169-181 negative elongation factor complex member C/D Homo sapiens 375-378