PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6364828-5	1984	Because glycolysis controls hexose-induced insulin release, glucokinase is considered the best-qualified candidate for the elusive glucose sensor of beta-cells.	Hexoses	28-34	glucokinase	Homo sapiens	60-71	
2970227-5	1988	Two explanations have been proposed: 1) glucokinase, which has the same anomeric preference, is the principal hexose phosphorylating enzyme and limits glycolytic rate.	Hexoses	110-116	glucokinase	Homo sapiens	40-51	
8904921-2	1996	In terms of physiology, emphasis is placed on the relevance of glucokinase to hexose-induced insulin release, protein-to-protein interaction and enzyme-to-enzyme channelling, and the preferential stimulation of mitochondrial oxidative events in glucose-stimulated B-cells.	Hexoses	78-84	glucokinase	Homo sapiens	63-74	
7730377-10	1995	The results implicate a dual role for Ser-151 as a determinant of hexose affinity and catalysis, exclusive of the glucose-induced conformational change, and suggest that the low hexose affinity of glucokinase is dependent on interaction of Ser-151 with other regions of the protein.	Hexoses	178-184	glucokinase	Homo sapiens	197-208	
8679719-0	1996	Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release.	Hexoses	67-73	glucokinase	Homo sapiens	41-52	
8679719-1	1996	The present study reevaluates the relevance of human B-cell glucokinase activity to the process of hexose-induced insulin release.	Hexoses	99-105	glucokinase	Homo sapiens	60-71	
7961659-8	1994	The results 1) confirm the predictions of the model that Asn-204, Glu-256, and Glu-290 are important residues involved in catalysis and hydrogen bonding glucose hydroxyl groups, 2) provide evidence for a role of Lys-56 in hexose binding, and 3) are consistent with the cooperative behavior of glucokinase being mediated by interactions of other regions of the protein with the highly conserved active site glucose binding residues.	Hexoses	222-228	glucokinase	Homo sapiens	293-304	
2189759-2	1990	Glucokinase explains the capacity, hexose specificity, affinities, sigmoidicity, and anomeric preference of pancreatic islet glycolysis, and because stimulation of glucose metabolism is a prerequisite of glucose stimulation of insulin release, glucokinase also explains many characteristics of this beta-cell function.	Hexoses	35-41	glucokinase	Homo sapiens	0-11