PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27572707-0 2016 A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies. benzimidazole 83-96 sucrase-isomaltase Homo sapiens 56-73 26894559-1 2016 Benzimidazole analogs 1-27 were synthesized, characterized by EI-MS and (1)HNMR and their alpha-glucosidase inhibitory activities were found out experimentally. benzimidazole 0-13 sucrase-isomaltase Homo sapiens 90-107 31838286-1 2020 In this study, a series of benzimidazole-1,2,3-triazole hybrids 8a-n as new alpha-glucosidase inhibitors were designed and synthesized. benzimidazole 27-55 sucrase-isomaltase Homo sapiens 76-93 34153810-4 2021 The target benzimidazole 3f containing hydroxyl motif at para-position of phenyl revealed an important activity inhibitor against alpha- amylase (IC50 = 12.09 +- 0.38 microM) and alpha-glucosidase (IC50 = 11.02 +- 0.04 microM) comparable to the reference drug acarbose. benzimidazole 11-24 sucrase-isomaltase Homo sapiens 179-196 31699396-0 2020 Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study. benzimidazole 62-75 sucrase-isomaltase Homo sapiens 20-37 31699396-5 2020 Current study deals with the synthesis and biological screening of benzimidazole bearing bis-Schiff bases (1-19) for their alpha-glucosidase inhibitory activity. benzimidazole 67-80 sucrase-isomaltase Homo sapiens 123-140 31838286-0 2020 Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential alpha-glucosidase inhibitors. benzimidazole 43-71 sucrase-isomaltase Homo sapiens 93-110 30411010-0 2018 Efficient Synthesis and in Silico Studies of the Benzimidazole Hybrid Scaffold with the Quinolinyloxadiazole Skeleton with Potential alpha-Glucosidase Inhibitory, Anticoagulant, and Antiplatelet Activities for Type-II Diabetes Mellitus Management and Treating Thrombotic Disorders. benzimidazole 49-62 sucrase-isomaltase Homo sapiens 133-150 30411010-4 2018 In addition, molecular docking studies revealed that benzimidazole-containing quinolinyl oxadiazoles can correctly dock into the target receptor protein of the human intestinal alpha-glucosidase, while their bioavailability/drug-likeness was predicted to be acceptable but requires further optimization. benzimidazole 53-66 sucrase-isomaltase Homo sapiens 177-194 30411010-9 2018 These findings reveal that benzimidazole-containing quinolinyl oxadiazoles act as alpha-glucosidase inhibitors to develop novel therapeutics for treating type-II diabetes mellitus and can act as lead molecules in drug discovery as potential antidiabetic and antithrombotic agents. benzimidazole 27-40 sucrase-isomaltase Homo sapiens 82-99