PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30727904-14 2019 The present series of 1H-benzimidazoles could be considered promising broad-spectrum antimicrobial candidates that deserve in future for preclinical antimicrobial evaluation and development of newer antimicrobial agents targeting microbial DHFR. benzimidazole 22-39 dihydrofolate reductase Homo sapiens 240-244 24428639-2 2014 The most potent inhibitors in this series contained a five-membered heterocycle at the 2-position of the benzimidazole, leading to highly potent and selective compounds that exploit the differences in the size of a binding pocket adjacent to the NADPH cofactor between the bacterial and human DHFR enzymes. benzimidazole 105-118 dihydrofolate reductase Homo sapiens 293-297