PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34482215-4 2021 The study aimed to generate a homology model for the beta-tubulin of S. mansoni using the crystal structure of O visaries (Sheep) beta-tubulin (PDB ID: 3N2G D) as a template, then different beta-tubulin models were generated and two previously reported benzimidazole derivatives (NBTP-F and NBTP-OH) were docked to the generated models, the binding results indicated that both S. mansoni, S. haematobium were susceptible to the two NBTP derivatives. benzimidazole 253-266 beta-tubulin Ovis aries 53-65 34482215-7 2021 Moreover, additional seven new benzimidazole derivatives were synthesized and tested by molecular docking on the generated model binding site of S. mansoni beta-tubulin and were found to have good interaction inside the pocket. benzimidazole 31-44 beta-tubulin Ovis aries 156-168 33174071-2 2021 Results from the in vivo and in vitro tests were compared with benzimidazole (BZ)-resistance-associated beta-tubulin allele frequencies determined using Pyrosequencing . benzimidazole 63-76 beta-tubulin Ovis aries 104-116 33174071-2 2021 Results from the in vivo and in vitro tests were compared with benzimidazole (BZ)-resistance-associated beta-tubulin allele frequencies determined using Pyrosequencing . benzimidazole 78-80 beta-tubulin Ovis aries 104-116 33174071-6 2021 Genotyping indicated that the susceptible strain had 10% BZ-resistant beta-tubulin codon 200 alleles and the resistant strain had 26% respective resistant alleles. benzimidazole 57-59 beta-tubulin Ovis aries 70-82 18192899-7 2008 The SNPs 200Tyr, 167Tyr in beta-tubulin isotype 1 have been described to confer benzimidazole resistance in nematodes and recently 198Ala has also been associated with benzimidazole resistance. benzimidazole 80-93 beta-tubulin Ovis aries 27-39 18192899-7 2008 The SNPs 200Tyr, 167Tyr in beta-tubulin isotype 1 have been described to confer benzimidazole resistance in nematodes and recently 198Ala has also been associated with benzimidazole resistance. benzimidazole 168-181 beta-tubulin Ovis aries 27-39 18192899-9 2008 These genetic analyses indicate that there is a correlation between exposure and/or resistance to MLs and an increase in the frequency of the beta-tubulin alleles containing codons, which are determinant for benzimidazole resistance. benzimidazole 208-221 beta-tubulin Ovis aries 142-154