PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34128259-0 2021 Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor. benzimidazole 54-67 sphingosine kinase 1 Homo sapiens 83-103 34128259-4 2021 Our design strategy is twofold: It aimed first to study the effect of replacing the 5-position of the benzimidazole ring with a polar carboxylic acid group on the SphK1-inhibitory activity and cytotoxicity. benzimidazole 102-115 sphingosine kinase 1 Homo sapiens 163-168 34128259-7 2021 The binding affinity of the benzimidazole derivatives toward SphK1 was measured by fluorescence binding and molecular docking. benzimidazole 28-41 sphingosine kinase 1 Homo sapiens 61-66