PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18763755-1 2008 We previously reported that 1 (BMS-536924), a benzimidazole inhibitor of the insulin-like growth factor-1 receptor, had demonstrated in vivo antitumor activity. benzimidazole 46-59 insulin like growth factor 1 receptor Homo sapiens 77-114 20545947-1 2010 From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis. benzimidazole 8-17 insulin like growth factor 1 receptor Homo sapiens 109-115 21220496-10 2011 These data suggest that benzimidazole IGF-1R/InsR inhibitors may select for upregulation and be effluxed by the ATP-binding cassette transporter, BCRP, contributing to resistance. benzimidazole 24-37 insulin like growth factor 1 receptor Homo sapiens 38-44 20153189-0 2010 SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. benzimidazole 30-43 insulin like growth factor 1 receptor Homo sapiens 50-56 18572407-0 2008 Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors. benzimidazole 50-63 insulin like growth factor 1 receptor Homo sapiens 70-76