PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21858223-9	2011	However, the down-regulation of FOXM1 by either thiostrepton or U0126 required the presence of p53 in ovarian cancer cells.	Thiostrepton	48-60	tumor protein p53	Homo sapiens	95-98	
25426548-0	2014	Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells.	Thiostrepton	43-55	tumor protein p53	Homo sapiens	20-23	
21224072-4	2011	We found that well-known proteasome inhibitors such as MG132 and bortezomib, as well as the recently discovered proteasome inhibitor thiostrepton, induced p53-independent apoptosis in human cancer cell lines that correlated with p53-independent induction of proapoptotic Noxa but not Puma protein.	Thiostrepton	133-145	tumor protein p53	Homo sapiens	155-158	
21224072-4	2011	We found that well-known proteasome inhibitors such as MG132 and bortezomib, as well as the recently discovered proteasome inhibitor thiostrepton, induced p53-independent apoptosis in human cancer cell lines that correlated with p53-independent induction of proapoptotic Noxa but not Puma protein.	Thiostrepton	133-145	tumor protein p53	Homo sapiens	229-232	
21224072-6	2011	Notably, thiostrepton induced more potent apoptosis in HepG2 cells with p53 knockdown than in parental cells with wild-type p53.	Thiostrepton	9-21	tumor protein p53	Homo sapiens	72-75	
21224072-6	2011	Notably, thiostrepton induced more potent apoptosis in HepG2 cells with p53 knockdown than in parental cells with wild-type p53.	Thiostrepton	9-21	tumor protein p53	Homo sapiens	124-127	
29665004-0	2018	Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells.	Thiostrepton	0-12	tumor protein p53	Homo sapiens	29-32	
29665004-4	2018	In order to elucidate the mechanism of thiostrepton triggered mutant p53 degradation, we explored the impact of proteasome inhibition on activation of autophagy.	Thiostrepton	39-51	tumor protein p53	Homo sapiens	69-72	
29665004-5	2018	Combined treatment of thiostrepton and cycloheximide/chloroquine prevented the degradation of mutant p53 protein, reinforcing autophagy as the means of mutant p53 destabilization.	Thiostrepton	22-34	tumor protein p53	Homo sapiens	101-104	
29665004-5	2018	Combined treatment of thiostrepton and cycloheximide/chloroquine prevented the degradation of mutant p53 protein, reinforcing autophagy as the means of mutant p53 destabilization.	Thiostrepton	22-34	tumor protein p53	Homo sapiens	159-162	
29665004-7	2018	Subsequent interactome analysis performed post thiostrepton treatment revealed an association of p53 with autophagosome complex associated proteins such as BAG3, p62 and HSC70.	Thiostrepton	47-59	tumor protein p53	Homo sapiens	97-100	
29665004-8	2018	Reaccumulation of p53 was seen in BAG3 silenced cells treated with thiostrepton, thereby confirming the role of BAG3 in destabilization of this molecule.	Thiostrepton	67-79	tumor protein p53	Homo sapiens	18-21	
25337187-8	2014	FoxM1 inhibition by thiostrepton induced apoptosis of NPC cells by down-regulation of bcl-2, up-regulation of bax and p53, and inducing release of cytochrome c accompanied by activation of caspase-9, cleaved caspase-3 and cleaved PARP.	Thiostrepton	20-32	tumor protein p53	Homo sapiens	118-121	
19652535-0	2009	Wild-type p53 protects normal cells against apoptosis induced by thiostrepton.	Thiostrepton	65-77	tumor protein p53	Homo sapiens	10-13	
20058240-1	2010	BACKGROUND: We previously described the identification of a transcriptional inhibitor ARC and FoxM1 inhibitors, thiazole antibiotics, Siomycin A and thiostrepton that were able to induce potent p53-independent apoptosis in cancer cell lines of different origin.	Thiostrepton	149-161	tumor protein p53	Homo sapiens	194-197	
19652535-4	2009	We found that only normal cells that have wild-type p53 were resistant to the thiazole antibiotic, thiostrepton, suggesting that p53 plays an antiapoptotic role in normal cells.	Thiostrepton	99-111	tumor protein p53	Homo sapiens	52-55	
19652535-4	2009	We found that only normal cells that have wild-type p53 were resistant to the thiazole antibiotic, thiostrepton, suggesting that p53 plays an antiapoptotic role in normal cells.	Thiostrepton	99-111	tumor protein p53	Homo sapiens	129-132	
19652535-5	2009	In this case p53 status, but not the transformation of cells per se determines their sensitivity to thiostrepton and possibly to other anticancer drugs.	Thiostrepton	100-112	tumor protein p53	Homo sapiens	13-16	
19652535-6	2009	Since p53 is mutated in 50% of human cancers, thiostrepton may selectively kill cancer, but not normal cells.	Thiostrepton	46-58	tumor protein p53	Homo sapiens	6-9	
19672316-4	2009	Here, we report that Siomycin A and thiostrepton stabilize the expression of a variety of proteins, such as p21, Mcl-1, p53 and hdm-2 and also act as proteasome inhibitors in vitro.	Thiostrepton	36-48	tumor protein p53	Homo sapiens	120-123