PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28604387-0	2017	Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.	Macrolides	0-10	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	38-43	
29409357-0	2018	Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism.	Macrolides	0-10	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	15-20	
28993452-0	2017	Macrolides Blunt Aldosterone Biosynthesis: A Proof-of-Concept Study in KCNJ5 Mutated Adenoma Cells Ex Vivo.	Macrolides	0-10	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	71-76	
28993452-2	2017	Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which concentration dependently blunts aldosterone production in HAC15 transfected with the G151R and L168R mutated channel, we herein tested the effect of clarithromycin on aldosterone synthesis and secretion in a pure population of aldosterone-secreting cells obtained by immunoseparation (CD56+ cells) from APA tissues with/without the 2 most common KCNJ5 mutations.	Macrolides	91-100	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	8-13	
28993452-2	2017	Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which concentration dependently blunts aldosterone production in HAC15 transfected with the G151R and L168R mutated channel, we herein tested the effect of clarithromycin on aldosterone synthesis and secretion in a pure population of aldosterone-secreting cells obtained by immunoseparation (CD56+ cells) from APA tissues with/without the 2 most common KCNJ5 mutations.	Macrolides	91-100	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	467-472	
34440230-6	2021	The interaction between macrolides and KCNJ5 protein was evaluated via molecular docking and molecular dynamics simulation analysis.	Macrolides	24-34	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	39-44