PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30885990-3	2019	We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting in improved diabetic wound healing.	Pyruvaldehyde	25-28	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	229-238	
30885990-6	2019	IRE1alpha expression and activation in BMPCs were significantly attenuated by MGO exposure but rescued by GLO1 overexpression.	Pyruvaldehyde	78-81	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	0-9	
30885990-7	2019	MGO can diminish IRE1alpha RNase activity by directly binding to IRE1alpha in vitro.	Pyruvaldehyde	0-3	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	17-26	
30885990-7	2019	MGO can diminish IRE1alpha RNase activity by directly binding to IRE1alpha in vitro.	Pyruvaldehyde	0-3	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	65-74	
30885990-10	2019	In conclusion, our data suggest that GLO1 rescues BMPC dysfunction and facilitates wound healing in diabetic animals, at least partly through preventing MGO-induced impairment of IRE1alpha expression and activity.	Pyruvaldehyde	153-156	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	179-188