PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35405976-6 2022 Furthermore, in a cell-based reporter gene assay MGO, GO, and 3-DG were able to induce Nrf2-mediated gene expression in a dose-dependent manner. Pyruvaldehyde 49-52 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 34062923-5 2021 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde 82-84 NFE2 like bZIP transcription factor 2 Homo sapiens 348-352 34062923-5 2021 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde 147-149 NFE2 like bZIP transcription factor 2 Homo sapiens 348-352 34062923-5 2021 The cells were exposed to OP at 50 microM for 24 h prior to the administration of MG at 300 microM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Pyruvaldehyde 278-280 NFE2 like bZIP transcription factor 2 Homo sapiens 348-352 35405976-7 2022 Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. Pyruvaldehyde 218-221 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 34102705-6 2022 Sciadopitysin attenuated intracellular Ca2+ , NOX4 levels, oxidative stress, and MG-protein adduct levels, and increased nuclear Nrf2 and glyoxalase 1 levels in the presence of MG. Pyruvaldehyde 177-179 NFE2 like bZIP transcription factor 2 Homo sapiens 129-133 35316449-10 2022 Moreover, silencing of Nrf2 blocked the ISO-dependent gamma-GCL and GSH upregulation and the effects on the mitochondria of the MG-challenged cells. Pyruvaldehyde 128-130 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 35316449-11 2022 Then, ISO caused mitochondrial protection by an AMPK-PI3K/Akt/Nrf2/gamma-GCL/GSH-dependent manner in MG-administrated SH-SY5Y cells. Pyruvaldehyde 101-103 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 35405976-7 2022 Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. Pyruvaldehyde 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 35405976-7 2022 Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. Pyruvaldehyde 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 199-203 31359290-0 2019 Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal. Pyruvaldehyde 141-154 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 33392911-0 2021 The Isothiocyanate Sulforaphane Depends on the Nrf2/gamma-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. Pyruvaldehyde 128-141 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 33392911-9 2021 Inhibition of gamma-GCL with buthionine sulfoximine (BSO) or silencing of Nrf2 using small interfering RNA (siRNA) against this transcription factor reduced the levels of GSH and abolished the mitochondrial protection promoted by SFN in the MG-treated cells. Pyruvaldehyde 241-243 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 33392911-10 2021 Thus, SFN protected mitochondria of the MG-challenged cells by a mechanism involving the Nrf2/gamma-GCL/GSH axis. Pyruvaldehyde 40-42 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 35013107-11 2022 As expected, MET reversed MGO-induced downregulation of Nrf2 and p-Akt. Pyruvaldehyde 26-29 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 35013107-12 2022 In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects. Pyruvaldehyde 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 35013107-12 2022 In addition, a PI3K inhibitor (LY-294002) and a Nrf2 inhibitor (ML385) observably attenuated the protective effects of MET on MGO-induced apoptosis and ROS generation by inhibiting the Nrf2/HO-1 pathways, while a ROS scavenger (NAC) and a permeability transition pores inhibitor (CsA) completely reversed these effects. Pyruvaldehyde 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 185-189 32930996-11 2021 Therefore, EM protected the mitochondria by a mechanism dependent on the AMPK/Nrf2/HO-1 signaling pathway in MG-challenged SH-SY5Y cells. Pyruvaldehyde 109-111 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 33411218-10 2021 Thus, CA promoted mitochondrial protection by a PI3K/Akt/Nrf2/gamma-GCL/GSH axis in MG-treated SH-SY5Y cells. Pyruvaldehyde 84-86 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 31494842-8 2020 Moreover, silencing of the transcription factor nuclear factor E2-related factor 2 (Nrf2) suppressed the mitochondrial protection promoted by KW in the MG-challenged cells. Pyruvaldehyde 152-154 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 31767834-2 2019 A recent study has shown that phosphoglycerate kinase 1 (PGK1) inhibition/depletion will lead to Kelch-like ECH-associated protein 1 (Keap1) methylglyoxal modification, thereby activating Nrf2 signaling cascade. Pyruvaldehyde 141-154 NFE2 like bZIP transcription factor 2 Homo sapiens 188-192 31359290-13 2019 Therefore, T-I induced mitochondrial protection by a mechanism involving the Nrf2/GSH axis in MG-challenged SH-SY5Y cells. Pyruvaldehyde 94-96 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 28000163-9 2017 Therefore, PB activated the Erk1/2-Nrf2 signaling pathway resulting in mitochondrial protection in SH-SY5Y cells exposed to MG. Pyruvaldehyde 124-126 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 28263721-0 2017 Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2. Pyruvaldehyde 53-67 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 28263721-4 2017 Results show that 7-HC pretreatment significantly attenuates MG-induced cytotoxicity, apoptotic changes and ROS accumulation and that this protection is shown to be associated with the induction of the nuclear factor erythroid 2-related factor 2 (NRF2) and its downstream detoxifying enzymes. Pyruvaldehyde 61-63 NFE2 like bZIP transcription factor 2 Homo sapiens 202-245 28263721-4 2017 Results show that 7-HC pretreatment significantly attenuates MG-induced cytotoxicity, apoptotic changes and ROS accumulation and that this protection is shown to be associated with the induction of the nuclear factor erythroid 2-related factor 2 (NRF2) and its downstream detoxifying enzymes. Pyruvaldehyde 61-63 NFE2 like bZIP transcription factor 2 Homo sapiens 247-251 28263721-6 2017 In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC. Pyruvaldehyde 100-102 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 28263721-6 2017 In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC. Pyruvaldehyde 100-102 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 28263721-7 2017 These findings highlight the potential for the interventional activation of the NRF2 induction via the non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the detoxification of MG, with the aim of halting the progression of diseases in which MG has been implicated. Pyruvaldehyde 202-204 NFE2 like bZIP transcription factor 2 Homo sapiens 80-84 28263721-7 2017 These findings highlight the potential for the interventional activation of the NRF2 induction via the non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the detoxification of MG, with the aim of halting the progression of diseases in which MG has been implicated. Pyruvaldehyde 267-269 NFE2 like bZIP transcription factor 2 Homo sapiens 80-84 28916747-6 2017 Moreover, upon exogenous MG challenge, glycolytic cells showed elevated amounts of intracellular MG and induced de novo GLO1 detoxifying enzyme and Nrf2 expression. Pyruvaldehyde 25-27 NFE2 like bZIP transcription factor 2 Homo sapiens 148-152 28371750-0 2017 Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Pyruvaldehyde 105-118 NFE2 like bZIP transcription factor 2 Homo sapiens 144-148 28371750-12 2017 These results suggested that Na2S protects SH-SY5Y cells from MG cytotoxicity through the activation of Nrf2, mediated by cysteine persulfides and polysulfides that were generated by Na2S addition. Pyruvaldehyde 62-64 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 31254498-10 2019 Therefore, NGN caused mitochondrial protection by an Nrf2/GSH-dependent manner in SH-SY5Y cells exposed to MG. Pyruvaldehyde 107-109 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 30179128-10 2018 CONCLUSION: Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications. Pyruvaldehyde 21-23 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 30179128-10 2018 CONCLUSION: Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications. Pyruvaldehyde 190-192 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 28073699-8 2017 It was, therefore, determined that promotion of GSH synthesis via the Nrf2/Keap1pathway is important in the MG detoxification mechanism against neuronal MG-induced carbonyl stress, and Nrf2 activators contribute to reduction in the accumulation and toxic expression of carbonyl proteins. Pyruvaldehyde 108-110 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 28073699-0 2017 Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. Pyruvaldehyde 57-70 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 28073699-2 2017 The involvement of nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway as a defense response against the formation of MG-modified proteins, which is well-known evidence of carbonyl stress, was also examined. Pyruvaldehyde 169-171 NFE2 like bZIP transcription factor 2 Homo sapiens 19-62 28073699-2 2017 The involvement of nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway as a defense response against the formation of MG-modified proteins, which is well-known evidence of carbonyl stress, was also examined. Pyruvaldehyde 169-171 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 28073699-4 2017 This accumulation was suppressed by activation of the Nrf2 pathway prior to MG exposure via pre-treatment with an Nrf2 activator, carnosic acid and CDDO-Im, confirming the involvement of the Nrf2 pathway in MG detoxification. Pyruvaldehyde 76-78 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 28073699-4 2017 This accumulation was suppressed by activation of the Nrf2 pathway prior to MG exposure via pre-treatment with an Nrf2 activator, carnosic acid and CDDO-Im, confirming the involvement of the Nrf2 pathway in MG detoxification. Pyruvaldehyde 76-78 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 28073699-4 2017 This accumulation was suppressed by activation of the Nrf2 pathway prior to MG exposure via pre-treatment with an Nrf2 activator, carnosic acid and CDDO-Im, confirming the involvement of the Nrf2 pathway in MG detoxification. Pyruvaldehyde 207-209 NFE2 like bZIP transcription factor 2 Homo sapiens 54-58 28073699-4 2017 This accumulation was suppressed by activation of the Nrf2 pathway prior to MG exposure via pre-treatment with an Nrf2 activator, carnosic acid and CDDO-Im, confirming the involvement of the Nrf2 pathway in MG detoxification. Pyruvaldehyde 207-209 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 28073699-4 2017 This accumulation was suppressed by activation of the Nrf2 pathway prior to MG exposure via pre-treatment with an Nrf2 activator, carnosic acid and CDDO-Im, confirming the involvement of the Nrf2 pathway in MG detoxification. Pyruvaldehyde 207-209 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 28073699-8 2017 It was, therefore, determined that promotion of GSH synthesis via the Nrf2/Keap1pathway is important in the MG detoxification mechanism against neuronal MG-induced carbonyl stress, and Nrf2 activators contribute to reduction in the accumulation and toxic expression of carbonyl proteins. Pyruvaldehyde 153-155 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 24746615-4 2014 Here, we report the methylglyoxal-mediated sequential events responsible for Keap1 promoter DNA demethylation in human lens epithelial cells, because Keap1 is a negative regulatory protein that regulates the Nrf2 antioxidant protein. Pyruvaldehyde 20-33 NFE2 like bZIP transcription factor 2 Homo sapiens 208-212 26577515-9 2015 CA prevented MG-dependent neurotoxicity by activating the PI3K/Akt/Nrf2 signaling pathway and the antioxidant enzymes modulated by Nrf2 transcription factor. Pyruvaldehyde 13-15 NFE2 like bZIP transcription factor 2 Homo sapiens 67-71 26577515-9 2015 CA prevented MG-dependent neurotoxicity by activating the PI3K/Akt/Nrf2 signaling pathway and the antioxidant enzymes modulated by Nrf2 transcription factor. Pyruvaldehyde 13-15 NFE2 like bZIP transcription factor 2 Homo sapiens 131-135 25451587-0 2015 Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2. Pyruvaldehyde 35-49 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25451587-8 2015 We have also shown that MG was able to induce the translocation of the transcription factor Nrf2 to the nucleus. Pyruvaldehyde 24-26 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 25451587-11 2015 Nrf2 is critical in mediating MG induced expression of protective genes. Pyruvaldehyde 30-32 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 22917016-0 2012 Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells. Pyruvaldehyde 53-66 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 22917016-4 2012 The aim of this study was to evaluate resveratrol activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to attenuate MG-induced insulin resistance in Hep G2 cells. Pyruvaldehyde 128-130 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 22917016-4 2012 The aim of this study was to evaluate resveratrol activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to attenuate MG-induced insulin resistance in Hep G2 cells. Pyruvaldehyde 128-130 NFE2 like bZIP transcription factor 2 Homo sapiens 64-107