PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Pyruvaldehyde	42-45	mitogen-activated protein kinase 3	Homo sapiens	75-79	
26021238-6	2015	Signaling kinetic observation indicated that MGO remarkably triggered phosphorylation of Akt, ERK1/2, p38 MAPK, and JNK1/2.	Pyruvaldehyde	45-48	mitogen-activated protein kinase 3	Homo sapiens	94-100	
26021238-7	2015	Blockade of kinase activity demonstrated that the hyperphosphorylation of Akt, ERK1/2, JNK, and p38 MAPK were all involved in the MGO-enhanced autophagy and growth-arresting effect in ARPE-19 cells.	Pyruvaldehyde	130-133	mitogen-activated protein kinase 3	Homo sapiens	79-85	
26021238-7	2015	Blockade of kinase activity demonstrated that the hyperphosphorylation of Akt, ERK1/2, JNK, and p38 MAPK were all involved in the MGO-enhanced autophagy and growth-arresting effect in ARPE-19 cells.	Pyruvaldehyde	130-133	mitogen-activated protein kinase 3	Homo sapiens	100-104	
11425486-9	2001	These results demonstrated that GO and MGO triggered two distinct signal cascades, one for PTK-dependent control of ERK and another for PTK-independent redox-linked activation of JNK/p38 MAPK and caspases in HUVECs, depending on the structure of the carbon skeleton of the chemicals.	Pyruvaldehyde	39-42	mitogen-activated protein kinase 3	Homo sapiens	187-191	
31369791-5	2019	Quantitative RT-PCR revealed that bergenin decreased the expression of ERK1, Akt2, MMP-9, and OSTM1 genes in the presence of MG.	Pyruvaldehyde	125-127	mitogen-activated protein kinase 3	Homo sapiens	71-75	
28000163-9	2017	Therefore, PB activated the Erk1/2-Nrf2 signaling pathway resulting in mitochondrial protection in SH-SY5Y cells exposed to MG.	Pyruvaldehyde	124-126	mitogen-activated protein kinase 3	Homo sapiens	28-34	
17174344-10	2007	MG-AGE-induced phosphorylation of ERK1/2 and p38 was nullified by neutralizing AGE with specific anti-AGE antibody but not nonspecific antiserum.	Pyruvaldehyde	0-2	mitogen-activated protein kinase 3	Homo sapiens	34-40	
11425486-4	2001	GO and MGO also induced phosphorylations of JNK, p38 MAPK, and c-Jun, either PTK-dependently (GO) or -independently (MGO).	Pyruvaldehyde	7-10	mitogen-activated protein kinase 3	Homo sapiens	53-57	
11425486-4	2001	GO and MGO also induced phosphorylations of JNK, p38 MAPK, and c-Jun, either PTK-dependently (GO) or -independently (MGO).	Pyruvaldehyde	117-120	mitogen-activated protein kinase 3	Homo sapiens	53-57	
11425486-6	2001	Curcumin and SB203580, which inhibit JNK and p38 MAPK signaling pathways, but not herbimycin A/staurosporine, prevented the MGO-induced PARP degradation.	Pyruvaldehyde	124-127	mitogen-activated protein kinase 3	Homo sapiens	49-53	
32746708-8	2021	Additionally, GO and MGO significantly activated extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and NF-kappaB.	Pyruvaldehyde	21-24	mitogen-activated protein kinase 3	Homo sapiens	92-98	
32746708-9	2021	Whether ERK1/2, p38 MAPK, and NF-kappaB signaling pathway were involved in GO and MGO-induced production of pro-inflammatory cytokines (IL-1beta and IL-6) and MUC5AC/5B, we used specific inhibitors and siRNA transfection.	Pyruvaldehyde	82-85	mitogen-activated protein kinase 3	Homo sapiens	8-14	
32746708-11	2021	CONCLUSIONS: GO and MGO induced pro-inflammatory cytokines and MUC5AC/5B expression via ERK1/2, p38 MAPK, and NF-kappaB in human nasal epithelial cells.	Pyruvaldehyde	20-23	mitogen-activated protein kinase 3	Homo sapiens	88-94