PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1459997-2 1992 In principle, competitive inhibitors of glyoxalase I that also serve as substrates for the thioester hydrolase glyoxalase II might function as tumor-selective anti-cancer agents, given the role of these enzymes in removing cytotoxic methylglyoxal from cells and the observation that glyoxalase II activity is abnormally low in some types of cancer cells. Pyruvaldehyde 233-246 hydroxyacylglutathione hydrolase Bos taurus 111-124 9486985-2 1998 Glyoxalase-I catalyzes the conversion of MG to S-D-lactoylglutathione, which in turn is converted to D-lactate by glyoxalase-II. Pyruvaldehyde 41-43 hydroxyacylglutathione hydrolase Bos taurus 114-127