PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26560472-1 2016 OBJECTIVES: We investigated the possible involvement of multidrug resistance protein 1 P-glycoprotein (MDR1 P-gp) in the oxalate-induced redistribution of phosphatidylserine in renal epithelial cell membranes. Oxalates 121-128 ATP binding cassette subfamily B member 1 Canis lupus familiaris 103-107 26560472-3 2016 RESULTS: Oxalate treatment resulted in increased synthesis of MDR1, which resulted in phosphatidylserine (PS) externalization in the renal epithelial cell membrane. Oxalates 9-16 ATP binding cassette subfamily B member 1 Canis lupus familiaris 62-66 26560472-6 2016 CONCLUSIONS: To our knowledge, this study is the first to show that oxalate increases the synthesis of MDR1 P-gp, which plays a key role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells. Oxalates 68-75 ATP binding cassette subfamily B member 1 Canis lupus familiaris 103-107