PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15499208-8	2004	Both oxalate and calcium oxalate crystals selectively activate p38 mitogen-activated protein kinase in the exposed tubular cells.	Oxalates	5-12	mitogen activated protein kinase 14	Rattus norvegicus	63-66	
19839830-8	2009	PJ was found to have inhibitory effects on renal tubular cell injury and oxidative stress caused by oxalate crystals by reducing ROS, iNOS, p38-MAPK, and NF-kB expression.	Oxalates	100-107	mitogen activated protein kinase 14	Rattus norvegicus	140-148	
29653411-4	2018	In addition, oxalate-induced p38 phosphorylation was significantly attenuated by chloroquine pretreatment but was markedly enhanced by rapamycin pretreatment, whereas the protective effect of chloroquine on rat renal tubular cell oxidative injury was partly reversed by a p38 protein kinase activator anisomycin.	Oxalates	13-20	mitogen activated protein kinase 14	Rattus norvegicus	29-32	
29653411-4	2018	In addition, oxalate-induced p38 phosphorylation was significantly attenuated by chloroquine pretreatment but was markedly enhanced by rapamycin pretreatment, whereas the protective effect of chloroquine on rat renal tubular cell oxidative injury was partly reversed by a p38 protein kinase activator anisomycin.	Oxalates	13-20	mitogen activated protein kinase 14	Rattus norvegicus	272-275	
29653411-6	2018	Taken together, our results revealed that autophagy inhibition could attenuate oxalate-induced oxidative injury of renal tubular cell and CaOx crystal depositions in the rat kidney via, at least in part, inhibiting the activation of p38 signaling pathway, thus representing a novel role of autophagy in the regulation of oxalate-induced renal oxidative injury and CaOx crystal depositions for the first time.	Oxalates	79-86	mitogen activated protein kinase 14	Rattus norvegicus	233-236	
29653411-6	2018	Taken together, our results revealed that autophagy inhibition could attenuate oxalate-induced oxidative injury of renal tubular cell and CaOx crystal depositions in the rat kidney via, at least in part, inhibiting the activation of p38 signaling pathway, thus representing a novel role of autophagy in the regulation of oxalate-induced renal oxidative injury and CaOx crystal depositions for the first time.	Oxalates	321-328	mitogen activated protein kinase 14	Rattus norvegicus	233-236