PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8276819-2	1994	Treatment of A-549 human lung adenocarcinoma cells with okadaic acid increased expression of the IGF-II mRNAs.	Okadaic Acid	56-68	insulin like growth factor 2	Homo sapiens	97-103	
9473490-6	1998	However, IGF-II could suppress K(+)-stimulated insulin release when cells were pretreated with the protein phosphatase inhibitor okadaic acid.	Okadaic Acid	129-141	insulin like growth factor 2	Homo sapiens	9-15	
9295313-7	1997	The effect of glucose on IGF-II binding was mimicked by fructose (10 mM), but not by 3-O-methylglucose (10 mM), and was abolished by the protein kinase C (PKC) inhibitor calphostin C, or down-regulation of PKC, but not by the protein phosphatase inhibitor, okadaic acid.	Okadaic Acid	257-269	insulin like growth factor 2	Homo sapiens	25-31	
8276819-3	1994	Since the 4.8-kb mRNA is transcribed under the control of human IGF-II P4 promoter, we examined the P4 promoter element responsible for the okadaic acid-mediated transcriptional activation.	Okadaic Acid	140-152	insulin like growth factor 2	Homo sapiens	64-70	
8276819-4	1994	Transfection of IGF-II P4 promoter-chloramphenicol acetyltransferase constructs demonstrated that the effects of okadaic acid on the induction of IGF-II gene expression are mediated through multiple promoter elements, including an Egr-1 consensus element.	Okadaic Acid	113-125	insulin like growth factor 2	Homo sapiens	16-22	
8276819-4	1994	Transfection of IGF-II P4 promoter-chloramphenicol acetyltransferase constructs demonstrated that the effects of okadaic acid on the induction of IGF-II gene expression are mediated through multiple promoter elements, including an Egr-1 consensus element.	Okadaic Acid	113-125	insulin like growth factor 2	Homo sapiens	146-152	
8392806-4	1993	Subcellular fractionation indicated that the okadaic acid-induced stimulation of IGF-II binding resulted from an increase in the number of IGF-II receptors in the plasma membrane with a concomitant disappearance from the low-density microsomal fraction.	Okadaic Acid	45-57	insulin like growth factor 2	Homo sapiens	81-87	
8392806-4	1993	Subcellular fractionation indicated that the okadaic acid-induced stimulation of IGF-II binding resulted from an increase in the number of IGF-II receptors in the plasma membrane with a concomitant disappearance from the low-density microsomal fraction.	Okadaic Acid	45-57	insulin like growth factor 2	Homo sapiens	139-145	
8392806-6	1993	Both insulin-stimulated glucose transport and IGF-II binding were prevented when cells were pretreated with okadaic acid.	Okadaic Acid	108-120	insulin like growth factor 2	Homo sapiens	46-52	
8392806-10	1993	Taken together, our data suggest that, in adipocytes, serine/threonine phosphorylation events mimicked by okadaic acid are required for the translocation of IGF-II receptors and glucose transporters.	Okadaic Acid	106-118	insulin like growth factor 2	Homo sapiens	157-163	
1324932-8	1992	Incubation of human fibroblasts with okadaic acid, a specific inhibitor of this phosphatase, resulted in a depletion of M6P/IGF II receptors at the cell surface without affecting their internalization kinetics.	Okadaic Acid	37-49	insulin like growth factor 2	Homo sapiens	124-130	
1324932-11	1992	While the decreased cell surface expression of receptors was reversible upon removal of okadaic acid the IGF II-induced redistribution of M6P/IGF II receptors to the plasma membrane (Braulke, T., Tippmer, S., Neher, E., and von Figura, K. (1989) EMBO J.	Okadaic Acid	88-100	insulin like growth factor 2	Homo sapiens	105-111