PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11306428-6	2001	In wild-type animals, silica-induced fibrosis correlated with markers of a T helper 2-like response such as upregulation of IL-4 levels in lung tissue and an increased immunoglobulin (Ig) G1/IgG2a ratio in BAL.	Silicon Dioxide	22-28	immunoglobulin heavy variable V1-9	Mus musculus	191-196	
11306428-8	2001	In transgenic mice, the level of IL-4 in lung homogenates was not significantly affected by silica treatment, and a reduced IgG1/IgG2a ratio was observed upon treatment with silica.	Silicon Dioxide	174-180	immunoglobulin heavy variable V1-9	Mus musculus	129-134	
26987867-3	2016	The mesoporous silica nanoparticle promotes both Th1 and Th2 immune responses, as it accelerates lymphocytes proliferation, stimulates IFN-gamma, IL-2, IL-4, and IL-10 cytokine secretion by lymphocytes ex vivo, and increases IgG, IgG1, IgG2a, IgM, and IgA antibody titers in mice serum compared with those of alum and adjuvant-free groups.	Silicon Dioxide	15-21	immunoglobulin heavy variable V1-9	Mus musculus	236-241	
26113229-5	2015	Instead, concurrent cutaneous exposure to mite allergens and silica nanoparticles resulted in the low-level production of allergen-specific IgGs, including both the Th2-related IgG1 and Th1-related IgG2a subtypes, with few changes in allergen-specific IgE concentrations and in Th1 and Th2 immune responses.	Silicon Dioxide	61-67	immunoglobulin heavy variable V1-9	Mus musculus	198-203