PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31692000-0 2020 Interleukin 1alpha and 1beta gene variations are associated with tuberculosis in silica exposed subjects. Silicon Dioxide 81-87 interleukin 1 alpha Homo sapiens 0-28 32140425-4 2020 The product BION-50 WG , that contains Acibenzolar-S-methyl (ASM) and silica particles did not present any cytotoxicity but induced a significant increase in the production of the inflammatory cytokine IL-1 beta. Silicon Dioxide 70-76 interleukin 1 alpha Homo sapiens 202-211 24332681-4 2014 Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Silicon Dioxide 29-35 interleukin 1 alpha Homo sapiens 267-276 30724633-0 2019 Silica nanoparticles as an enhancer in the IL-1beta-induced inflammation cycle of A549 cells. Silicon Dioxide 0-6 interleukin 1 alpha Homo sapiens 43-51 30724633-3 2019 However, whether nano-SiO2 can increase the IL-1beta-induced inflammatory expression in A549 cells has not been tested. Silicon Dioxide 22-26 interleukin 1 alpha Homo sapiens 44-52 30724633-9 2019 The synergistic effect of nano-SiO2 and IL-1beta was observed on the new production of IL-1beta and IL-6 in A549 cells. Silicon Dioxide 31-35 interleukin 1 alpha Homo sapiens 87-95 30724633-10 2019 The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta. Silicon Dioxide 42-46 interleukin 1 alpha Homo sapiens 78-86 30724633-10 2019 The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta. Silicon Dioxide 42-46 interleukin 1 alpha Homo sapiens 188-196 30724633-11 2019 IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells. Silicon Dioxide 39-43 interleukin 1 alpha Homo sapiens 0-8 30724633-12 2019 Discussion and conclusion: These results indicated that nano-SiO2 had a toxic effect on A549 cells, and this effect could increase IL-1beta on the A549 cell-induced inflammatory response. Silicon Dioxide 61-65 interleukin 1 alpha Homo sapiens 131-139 31407890-7 2019 Concentrations of interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor-alpha in macrophage supernatant increased following 100 mug/mL silica exposure for 24 h. Treatment of AMs with 500 muM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface. Silicon Dioxide 143-149 interleukin 1 alpha Homo sapiens 18-40 23746682-3 2013 The confinement of ionic liquids (especially IL1) inside the silica networks was suggested by thermogravimetric analysis and Fourier transform infrared spectroscopy. Silicon Dioxide 61-67 interleukin 1 alpha Homo sapiens 45-48 19633559-4 2009 In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis. Silicon Dioxide 121-127 interleukin 1 alpha Homo sapiens 97-101 23058021-5 2012 Silica stimulation showed a significant increase of IL-1alpha and IL-1beta in cultured medium, and an increased gene expression of CTGF in cultured fibroblasts at 1 hour, as well as an up-regulation of the COL1A2 gene at 24-hour time point. Silicon Dioxide 0-6 interleukin 1 alpha Homo sapiens 52-61 17241078-1 2007 The long-chain ionic liquid (IL) 1-hexadecyl-3-methylimidazolium chloride (C(16)mimCl) was used as a template to prepare porous silica with a two-dimensional hexagonal p6mm mesopore structure (MCM-41-type) as well as with a cubic Ia3d (gyroid, MCM-48-type structure) framework in basic synthesis medium via a hydrothermal synthesis procedure. Silicon Dioxide 128-134 interleukin 1 alpha Homo sapiens 15-34 8660820-4 1996 When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90%, but the production of interleukin-6 (IL-6) was not inhibited at all. Silicon Dioxide 49-55 interleukin 1 alpha Homo sapiens 125-129 12176706-2 2002 We recently published a case-control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1alpha (IL-1alpha), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor alpha (TNFalpha) as risk factors associated with silicosis, a fibrotic lung disease. Silicon Dioxide 82-88 interleukin 1 alpha Homo sapiens 141-159 12176706-2 2002 We recently published a case-control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1alpha (IL-1alpha), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor alpha (TNFalpha) as risk factors associated with silicosis, a fibrotic lung disease. Silicon Dioxide 82-88 interleukin 1 alpha Homo sapiens 161-170 11288755-10 2001 Northern blotting analysis showed increased interleukin-1alpha (IL-1alpha) mRNA after silica treatment. Silicon Dioxide 86-92 interleukin 1 alpha Homo sapiens 44-62 11288755-10 2001 Northern blotting analysis showed increased interleukin-1alpha (IL-1alpha) mRNA after silica treatment. Silicon Dioxide 86-92 interleukin 1 alpha Homo sapiens 64-73 11288755-13 2001 However, contradicting our hypothesis, silica antagonized TGFbeta activities through a TGFbeta downregulation and an IL-1alpha upregulation. Silicon Dioxide 39-45 interleukin 1 alpha Homo sapiens 117-126 11288755-14 2001 The complex pattern of TGFbeta and IL-1alpha regulation in pulmonary fibroblasts is imbalanced by silica exposure and might play a key role in silica-mediated pulmonary fibrosis. Silicon Dioxide 98-104 interleukin 1 alpha Homo sapiens 35-44 11288755-14 2001 The complex pattern of TGFbeta and IL-1alpha regulation in pulmonary fibroblasts is imbalanced by silica exposure and might play a key role in silica-mediated pulmonary fibrosis. Silicon Dioxide 143-149 interleukin 1 alpha Homo sapiens 35-44 7973152-11 1994 Silica-stimulated monocytes from patients also secreted more IL-1 than those from normal subjects (p < 0.001) in autologous mixed lymphocyte reaction. Silicon Dioxide 0-6 interleukin 1 alpha Homo sapiens 61-65 1506211-6 1992 In cell culture studies it has been shown that macrophages/monocytes release IL1, IL6 and TNF after ingestion of silica, which affects fibroblasts, T-helper cells and endothelial cells. Silicon Dioxide 113-119 interleukin 1 alpha Homo sapiens 77-80 8228619-0 1993 Silica induces apoptosis in macrophages and the release of interleukin-1 alpha and interleukin-1 beta. Silicon Dioxide 0-6 interleukin 1 alpha Homo sapiens 59-78 8228619-2 1993 The use of anti-IL-1 antisera showed that both IL-1 alpha and IL-1 beta were present in supernatants of silica-treated macrophages. Silicon Dioxide 104-110 interleukin 1 alpha Homo sapiens 47-57 8484101-5 1993 By contrast, IL-1 production by LPS- or silica-stimulated monocytes was not affected by this antibody. Silicon Dioxide 40-46 interleukin 1 alpha Homo sapiens 13-17 33379200-7 2020 Iron oxide increased IL-8 production while silica also induced significant production of IL-1beta. Silicon Dioxide 43-49 interleukin 1 alpha Homo sapiens 89-97 1667554-2 1991 AM IL-1 release was associated with the development of pulmonary granulomas after SiO2 exposure. Silicon Dioxide 82-86 interleukin 1 alpha Homo sapiens 3-7 1414690-1 1992 Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. Silicon Dioxide 112-118 interleukin 1 alpha Homo sapiens 15-19 2162329-3 1990 However, some of the opioids potentiated IL-1 production and release in macrophages concomitantly stimulated by lipopolysaccharide (LPS) or silica. Silicon Dioxide 140-146 interleukin 1 alpha Homo sapiens 41-45 2162329-4 1990 LPS induced predominantly intracellular IL-1 activity, whereas most of the silica-induced IL-1 was released extracellularly. Silicon Dioxide 75-81 interleukin 1 alpha Homo sapiens 90-94 2162329-5 1990 beta-Endorphin, leucine-enkephalin (leu-enkephalin) and beta-neoendorphin all potentiated both intracellular and extracellular release of IL 1 induced by either LPS or silica. Silicon Dioxide 168-174 interleukin 1 alpha Homo sapiens 138-142 33379200-8 2020 Both iron oxide and silica enhanced LPS-induced production of TNF-alpha, IL-1beta, IL-6 and IL-8 in THP-1 cells with most of these responses replicated in PBMCs. Silicon Dioxide 20-26 interleukin 1 alpha Homo sapiens 73-81 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 72-78 interleukin 1 alpha Homo sapiens 266-274 34766707-3 2022 We isolated primary AEC from three healthy adults and treated them with silica particles at different concentrations for 48 h. We found evidence for silica-induced inflammasome activation by the co-localization of Caspase-1 and NLRP3, as well as increased levels of IL-1beta and IL-18. Silicon Dioxide 149-155 interleukin 1 alpha Homo sapiens 266-274 34433619-4 2021 Phagocytosis of silica particles by macrophages is followed by recruitment of mitochondria to phagosomes, generation of mitochondrial reactive oxygen species, and cytokine (IL-1beta, TNF-alpha, IFN-beta) release. Silicon Dioxide 16-22 interleukin 1 alpha Homo sapiens 173-181 34336106-3 2021 Further, our study revealed that arctiin and arctigenin suppressed the activation of NLRP3 inflammasome through the TLR-4/Myd88/NF-kappaB pathway and the silica-induced secretion of TNF-alpha, IL-1beta, TGF-beta, and alpha-SMA. Silicon Dioxide 154-160 interleukin 1 alpha Homo sapiens 193-201 3257934-4 1988 Lysates of monocytes from patients also contained more interleukin-1 than those of controls (p less than 0.05) in the presence of lipopolysaccharide or silica, or both. Silicon Dioxide 152-158 interleukin 1 alpha Homo sapiens 55-68 35401236-4 2022 In vivo, our results showed that AKEX0011 ameliorated silica-induced imaging lung damages, respiratory dysfunction, reduced the secretion of inflammatory and fibrotic factors (TNF-alpha, IL-1beta, IL-6, TGF-beta, IL-4, and IL-10), and the deposition of fibrosis-related proteins (collagen I, fibronectin, and alpha-SMA), regardless of early or advanced therapy. Silicon Dioxide 54-60 interleukin 1 alpha Homo sapiens 187-195 2801317-3 1989 E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles. Silicon Dioxide 103-109 interleukin 1 alpha Homo sapiens 26-30 3138125-6 1988 However, silica-stimulated IL 1 release was normal in patients with newly diagnosed or short-term disease, but was significantly decreased in long-term diabetics. Silicon Dioxide 9-15 interleukin 1 alpha Homo sapiens 27-31 2839894-6 1988 Moreover, the finding that after silica stimulation the amount of membrane-associated IL-1 (which was recently shown to be of the IL-1 alpha type) was low, while IL-1 alpha in the culture fluid was clearly elevated, suggests that the IL-1 alpha not attached to the cell membrane (or released from it) significantly contributes to the secreted IL-1 pool. Silicon Dioxide 33-39 interleukin 1 alpha Homo sapiens 130-140 3000663-6 1986 Indeed, a supernatant from silica-treated human mononuclear cells containing IL-1 activity also enhanced cytotoxic and proliferative responses. Silicon Dioxide 27-33 interleukin 1 alpha Homo sapiens 77-81 2994686-2 1985 We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation. Silicon Dioxide 54-69 interleukin 1 alpha Homo sapiens 147-166 2999234-4 1985 Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4. Silicon Dioxide 99-105 interleukin 1 alpha Homo sapiens 11-15 2999234-4 1985 Similarly, IL 1 production by monocytes stimulated with the known IL 1 inducers muramyl dipeptide, silica, or zymosan was also enhanced by LTB4. Silicon Dioxide 99-105 interleukin 1 alpha Homo sapiens 66-70 2994686-2 1985 We found previously that crystals of sodium urate and silicon dioxide (silica) can stimulate the production of endogenous pyrogen (EP), now called interleukin-1 (IL-1), the polypeptide mediator of fever and other aspects of inflammation. Silicon Dioxide 71-77 interleukin 1 alpha Homo sapiens 147-166 3871221-2 1985 Human IL 1 was derived from the culture media of peripheral blood monocytes or placental cells that were stimulated with silica. Silicon Dioxide 121-127 interleukin 1 alpha Homo sapiens 6-10 2581705-1 1985 Human interleukin 1 (IL-1) in lipopolysaccharide and silica-stimulated human peripheral blood monocyte culture supernatants was purified to apparent homogeneity by sequential chromatography using DEAE-Sephacel, Sephacryl S-200, CM-high-performance liquid chromatography (HPLC), and hydroxyapatite-HPLC. Silicon Dioxide 53-59 interleukin 1 alpha Homo sapiens 6-25 2581705-4 1985 About 4.4 micrograms of IL-1 was purified from 5.0 liters of culture supernatant of lipopolysaccharide- and silica-stimulated human peripheral blood monocytes, with 46.6% recovery of biological activity. Silicon Dioxide 108-114 interleukin 1 alpha Homo sapiens 24-28 33053467-4 2021 HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)]. Silicon Dioxide 20-24 interleukin 1 alpha Homo sapiens 200-208 6309415-1 1983 Human interleukin 1 (IL-1) was produced under serum-free conditions by stimulating a human monocytic leukemia cell line (THP-1) with silica or lipopolysaccharide (LPS). Silicon Dioxide 133-139 interleukin 1 alpha Homo sapiens 6-25 6325057-2 1984 The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1. Silicon Dioxide 60-66 interleukin 1 alpha Homo sapiens 204-208 33144845-7 2020 Hence, the cells stimulated with SiO2 responded with a distinctly different IL-18 : IL-1beta ratio. Silicon Dioxide 33-37 interleukin 1 alpha Homo sapiens 84-92 33144845-8 2020 The difference in the IL-18 : IL-1beta ratio for SiO2 was constant over different doses. Silicon Dioxide 49-53 interleukin 1 alpha Homo sapiens 30-38 32223187-6 2020 In addition, silica increased the expression of interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), and T3 treatment reduced those pro-inflammatory cytokines secretion. Silicon Dioxide 13-19 interleukin 1 alpha Homo sapiens 68-76