PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17485301-2	2007	Heparin is a mixture of sulfated mucopolysaccharide with heterogeneity and is capable of forming multiple complexes with platelet factor 4 (PF4), released from activated platelets.	Heparin	0-7	platelet factor 4	Bos taurus	140-143	
8320164-0	1993	Carboxyl-terminal heparin-binding fragments of platelet factor 4 retain the blocking effect on the receptor binding of basic fibroblast growth factor.	Heparin	18-25	platelet factor 4	Bos taurus	47-64	
8320164-2	1993	In the present study, we constructed carboxyl-terminal fragments, which represent the heparin-binding region of the PF-4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF.	Heparin	86-93	platelet factor 4	Bos taurus	116-120	
1409574-10	1992	Our model of heparin bound to PF4 has the anionic polysaccharide perpendicular to the alpha-helices, wrapped about the tetramer along the ring of positive charge, and salt linked to all four lysines on the helix of each monomer.	Heparin	13-20	platelet factor 4	Bos taurus	30-33	
2914894-1	1989	Platelet factor 4 (PF4), which is released by platelets during coagulation, binds very tightly to negatively charged oligosaccharides such as heparin.	Heparin	142-149	platelet factor 4	Bos taurus	0-17	
2914894-1	1989	Platelet factor 4 (PF4), which is released by platelets during coagulation, binds very tightly to negatively charged oligosaccharides such as heparin.	Heparin	142-149	platelet factor 4	Bos taurus	19-22	
28118750-1	2017	Heparin-induced thrombocytopenia (HIT) is associated with antibodies to complexes between heparin and platelet factor 4 (PF4), a basic protein usually found in platelet alpha granules.	Heparin	0-7	platelet factor 4	Bos taurus	121-124	
28118750-2	2017	Heparin-induced thrombocytopenia antibodies preferentially recognize macromolecular complexes formed between positively charged PF4 and polyanionic heparins over a narrow range of molar ratios.	Heparin	0-7	platelet factor 4	Bos taurus	128-131	
28118750-4	2017	The resulting data of the PF4 complexes with unfractionated heparins (UFHs), LMWHs and their fractions, and oligosaccharide components suggest that the size of aggregates is not only a simple function of average molecular weight but also of the molecular weight distribution of the sample.	Heparin	60-68	platelet factor 4	Bos taurus	26-29	
28118750-4	2017	The resulting data of the PF4 complexes with unfractionated heparins (UFHs), LMWHs and their fractions, and oligosaccharide components suggest that the size of aggregates is not only a simple function of average molecular weight but also of the molecular weight distribution of the sample.	Heparin	70-74	platelet factor 4	Bos taurus	26-29	
28118750-5	2017	Moreover, it was found that lower concentrations of the tested ovine-derived mucosal heparin are required to form the large PF4/heparin complexes as compared to mucosal porcine and bovine heparin.	Heparin	85-92	platelet factor 4	Bos taurus	124-127	
12537186-14	2003	CONCLUSIONS: This study confirms the high frequency of heparin-PF4 antibodies after coronary artery bypass grafting and demonstrates a significantly higher incidence after bovine heparin.	Heparin	55-62	platelet factor 4	Bos taurus	63-66	
2713492-1	1989	Platelets secrete a low-molecular-weight protein, platelet factor four (PF-4), which binds to and neutralizes heparin and related sulfated glycosaminoglycans (GAGs).	Heparin	110-117	platelet factor 4	Bos taurus	72-76	
2725510-8	1989	These differences should significantly affect the secondary structure and heparin-binding properties of the protein based on considerations of the bovine PF4 crystal structure.	Heparin	74-81	platelet factor 4	Bos taurus	154-157	
28118750-5	2017	Moreover, it was found that lower concentrations of the tested ovine-derived mucosal heparin are required to form the large PF4/heparin complexes as compared to mucosal porcine and bovine heparin.	Heparin	128-135	platelet factor 4	Bos taurus	124-127