PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7833248-6 1995 Cell adhesion studies to dishes coated with the fibronectin 40 kD fragment, containing the heparin-binding domain, demonstrated that adhesiveness of IL-3-treated cells was higher than that of untreated cells. Heparin 91-98 fibronectin 1 Mus musculus 48-59 7576611-3 1995 A 40 kD COOH-terminal chymotryptic fragment of fibronectin containing both a heparin-binding region and an alternate (non-RGD) cell-binding site was inactive in supporting trophoblast adhesion. Heparin 77-84 fibronectin 1 Mus musculus 47-58 7833248-7 1995 These results suggest that in multipotent haemopoietic cells IL-3 regulates the amount of membrane-associated proteoglycans, which in turn modify the adhesive interactions of cells with the heparin-binding domain of fibronectin. Heparin 190-197 fibronectin 1 Mus musculus 216-227 1955379-0 1991 Recombinant fusion polypeptide with cell- and heparin-binding domains of fibronectin inhibits liver metastasis of L5178Y-ML25 lymphoma cells. Heparin 46-53 fibronectin 1 Mus musculus 73-84 7779998-3 1995 The results demonstrated that 1) in these blastocysts, contact of EPC cells with fibronectin-coated glass substratum in the presence of FBS triggered an outburst of cell proliferation with the eventual differentiation of the EPC cells into secondary giant trophoblast cells and 2) frequencies of blastocysts that exhibited EPC cell proliferation significantly increased if FO medium (modified Eagle"s minimum essential medium) was supplemented with FBS depleted of heparin-binding substances (H-FBS). Heparin 465-472 fibronectin 1 Mus musculus 81-92 1385448-8 1992 This inhibition by heparin was also observed with laminin and fibronectin and, in the case of perlecan, was found to be independent of heparin binding to substrate. Heparin 19-26 fibronectin 1 Mus musculus 62-73 8138582-6 1994 However, beta-xyloside treatment which reduces the abundance of membrane-associated CS-PG, as evidenced by molecular sieve chromatography, produced a major and specific decrease in HPC adhesion to the heparin-promoting binding fragment of fibronectin. Heparin 201-208 fibronectin 1 Mus musculus 239-250 2956270-4 1987 PD 31 cells recognize a different domain of the fibronectin molecule, which is contained within the carboxy terminal segment possessing a high-affinity binding site for heparin. Heparin 169-176 fibronectin 1 Mus musculus 48-59 2007184-5 1991 Instead, S115 cells growth without testosterone showed epithelial morphology and binding to the heparin-binding domain of FN, suggesting an alteration of syndecan expression in hormone-treated S115 cells. Heparin 96-103 fibronectin 1 Mus musculus 122-124 2387848-0 1990 Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin. Heparin 92-99 fibronectin 1 Mus musculus 130-141 2387848-0 1990 Modulation of haptotactic migration of metastatic melanoma cells by the interaction between heparin and heparin-binding domain of fibronectin. Heparin 104-111 fibronectin 1 Mus musculus 130-141 2387848-4 1990 At the same time, heparin or two monoclonal antibodies against the heparin-binding domain were able to inhibit the haptotactic migration to CH-271 or fibronectin, though not to C-274 or a mixture of C-274 and H-271. Heparin 18-25 fibronectin 1 Mus musculus 150-161 2387848-6 1990 It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain. Heparin 80-87 fibronectin 1 Mus musculus 157-168 2387848-6 1990 It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain. Heparin 131-138 fibronectin 1 Mus musculus 157-168 2387848-6 1990 It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain. Heparin 131-138 fibronectin 1 Mus musculus 157-168 2387848-6 1990 It seems likely that the regulatory mechanism may depend on interaction between heparin-like molecules on the cell surface and the heparin-binding domain in fibronectin, rather than on simple steric hindrance or on the masking of the cell-binding domain caused by the binding of heparin to heparin-binding domain. Heparin 131-138 fibronectin 1 Mus musculus 157-168 2963012-6 1988 Binding via the cell surface PG was to the COOH-terminal heparin binding domain of fibronectin. Heparin 57-64 fibronectin 1 Mus musculus 83-94 2963012-9 1988 These results indicate that the mammary epithelial cells have at least two distinct cell surface receptors for fibronectin: a trypsin-resistant molecule that binds cells to the sequence RGD and a trypsin-labile, heparan sulfate-rich PG that binds cells to the COOH-terminal heparin binding domain. Heparin 274-281 fibronectin 1 Mus musculus 111-122 2958379-3 1987 First, in the presence of soluble heparin, the rate at which embryos attach and outgrow on laminin, fibronectin, or monolayers of uterine epithelial cells is reduced considerably. Heparin 34-41 fibronectin 1 Mus musculus 100-111 2958379-4 1987 In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor. Heparin 73-80 fibronectin 1 Mus musculus 15-26 2958379-4 1987 In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor. Heparin 73-80 fibronectin 1 Mus musculus 178-189 2956468-5 1987 The glycosaminoglycan containing ectodomain of this PG binds with high affinity Type I, III and V collagen fibrils and the C-terminal heparin binding domain of fibronectin. Heparin 134-141 fibronectin 1 Mus musculus 160-171 3720853-0 1986 Substratum contacts and cytoskeletal reorganization of BALB/c 3T3 cells on a cell-binding fragment and heparin-binding fragments of plasma fibronectin. Heparin 103-110 fibronectin 1 Mus musculus 139-150 32069798-7 2020 Both NIH3T3 and A549 cells adhered to heparin/chitosan (HEP/CHI) film because HEP has an affinity for integrin through fibronectin. Heparin 38-45 fibronectin 1 Mus musculus 119-130 4010229-4 1985 Selective and partial inhibition of cell attachment to type I collagen, and, to a lesser extent, fibronectin, occurred upon preincubating these substrates with the sulfated glycosaminoglycans, heparin and heparan sulfate, at concentrations of 1 to 100 micrograms/ml; for 3T3 cells heparin was significantly more inhibitory (mean maximal inhibition of approximately 40%) than were two heparan sulfate fractions. Heparin 193-200 fibronectin 1 Mus musculus 97-108 20375066-7 2010 Studies with fragments indicated that both the RGD-synergy site and the adjacent heparin-binding region of fibronectin were required for full activity in mechanotransduction, but not its ability to self-assemble. Heparin 81-88 fibronectin 1 Mus musculus 107-118 24171489-8 2013 Cell behavior was highly dependent on pH during multilayer formation with heparin as polyanion and was closely related to fibronectin adsorption. Heparin 74-81 fibronectin 1 Mus musculus 122-133 21997473-5 2012 We were interested in studying the C-terminal heparin-binding region of FN since it mediates aggrecan and type II collagen breakdown in cartilage, but the specific FN domains responsible for proteolytic enzyme activity and their receptors in cartilage are unknown. Heparin 46-53 fibronectin 1 Mus musculus 72-74 21997473-7 2012 We found that the FN III 13-14 domains in the C-terminal heparin-binding region of FN are potent inducers of aggrecanase activity in articular cartilage. Heparin 57-64 fibronectin 1 Mus musculus 18-20 20547151-9 2010 However, this form of FN differs from other forms as it does not bind tightly to either gelatin or heparin. Heparin 99-106 fibronectin 1 Mus musculus 22-24 27867754-5 2016 Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H). Heparin 203-210 fibronectin 1 Mus musculus 21-32 27867754-5 2016 Approach: A chimeric fibronectin fragment was produced by inserting the integrin-binding Arg-Gly-Asp (RGD) loop from the tenth type III repeat of fibronectin (FNIII10) into the analogous site within the heparin-binding, bioactive fragment of the first type III repeat (FNIII1H). Heparin 203-210 fibronectin 1 Mus musculus 146-157 27161720-7 2016 RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells. Heparin 24-31 fibronectin 1 Mus musculus 149-160 27161720-7 2016 RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells. Heparin 33-36 fibronectin 1 Mus musculus 149-160 27161720-7 2016 RESULTS: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) both strongly inhibited migration as well as adhesion of SCLC cells to fibronectin and stromal cells. Heparin 63-70 fibronectin 1 Mus musculus 149-160 26661689-0 2016 Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin. Heparin 95-102 fibronectin 1 Mus musculus 21-32 26661689-0 2016 Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin. Heparin 95-102 fibronectin 1 Mus musculus 182-193 26661689-3 2016 This vasodilatory signal requires the heparin-binding matricryptic RWRPK sequence in the first type III repeat of fibrillar fibronectin. Heparin 38-45 fibronectin 1 Mus musculus 124-135 26661689-6 2016 Here we test the hypotheses that (i) the matricryptic heparin-binding region of the first type III repeat of fibrillar FN (FNIII1H) mediates vasodilatation, and (ii) this response is EC dependent. Heparin 54-61 fibronectin 1 Mus musculus 119-121 26661689-6 2016 Here we test the hypotheses that (i) the matricryptic heparin-binding region of the first type III repeat of fibrillar FN (FNIII1H) mediates vasodilatation, and (ii) this response is EC dependent. Heparin 54-61 fibronectin 1 Mus musculus 123-130 26661689-8 2016 Both FNIII1H,8-10 and FNIII1H induced dilatations (12.2 +- 1.7 mum, n = 12 and 17.2 +- 2.4 mum, n = 14, respectively) whereas mutation of the active sequence (R(613) WRPK) of the heparin binding region significantly diminished the dilatation (3.2 +- 1.8 mum, n = 10). Heparin 179-186 fibronectin 1 Mus musculus 22-29 20440757-7 2010 Residual particle-extracellular fibronectin matrix binding and 2 degrees transfer can be competitively disrupted by heparin exposure without affecting murine progenitor homing and repopulation. Heparin 116-123 fibronectin 1 Mus musculus 32-43 18674534-11 2008 As well, heparin counteracted the known inhibitory effect of fibronectin on adipogenesis and decreased basal focal adhesion kinase and paxillin phosphorylation. Heparin 9-16 fibronectin 1 Mus musculus 61-72 20223119-0 2009 [Recombinant polypeptide of N-terminal heparin-binding domain of fibronectin antagonizes hepatic failure induced by endotoxin in mice]. Heparin 39-46 fibronectin 1 Mus musculus 65-76 20223119-1 2009 OBJECTIVE: To study the preventive effect of recombinant polypeptide of N-terminal heparin-binding domain of fibronectin on hepatic failure induced by endotoxin in mice. Heparin 83-90 fibronectin 1 Mus musculus 109-120 11035040-0 2001 Altered processing of fibronectin in mice lacking heparin. Heparin 50-57 fibronectin 1 Mus musculus 22-33 11849388-9 2002 Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions. Heparin 5-12 fibronectin 1 Mus musculus 73-75 11849388-9 2002 Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions. Heparin 36-43 fibronectin 1 Mus musculus 73-75 11849388-9 2002 Both heparin and non-anti-coagulant heparin blocked the accumulation of pFN-FITC, indicating that the protective effect of heparin in the trapping of FN is independent of its anticoagulant properties, and probably results from preventing direct binding of FN in the sclerotic lesions. Heparin 36-43 fibronectin 1 Mus musculus 73-75 11737589-8 2001 Addition of neutralizing anti-HB-EGF antibody, as well as pretreatment with heparin or the metalloproteinase inhibitor batimastat abolished induction of FN expression by Ang II. Heparin 76-83 fibronectin 1 Mus musculus 153-155 16178272-9 2005 The increase in cell adhesion was observed on plastic dishes, albumin, as well as on fibronectin pre-coated ones suggesting that heparin effect is substratum independent. Heparin 129-136 fibronectin 1 Mus musculus 85-96 11035040-10 2001 Further experiments showed that the degradation of fibronectin observed in cell cultures from NDST-2(+/+) mice was catalyzed by mast cell chymase in a strongly heparin-dependent manner. Heparin 160-167 fibronectin 1 Mus musculus 51-62 8698481-5 1996 The inhibitory action depended on the fimbrial interaction with heparin-binding and cell attachment domains in the fibronectin structure. Heparin 64-71 fibronectin 1 Mus musculus 115-126 10852711-0 2000 Interaction with heparin and matrix metalloproteinase 2 cleavage expose a cryptic anti-adhesive site of fibronectin. Heparin 17-24 fibronectin 1 Mus musculus 104-115 10852711-1 2000 We recently found that fibronectin (FN) had a functional site [YTIYVIAL sequence in the heparin-binding domain 2 (Hep 2)] that was capable of suppressing the integrin-mediated cell adhesion to extracellular matrix. Heparin 88-95 fibronectin 1 Mus musculus 23-34 10852711-1 2000 We recently found that fibronectin (FN) had a functional site [YTIYVIAL sequence in the heparin-binding domain 2 (Hep 2)] that was capable of suppressing the integrin-mediated cell adhesion to extracellular matrix. Heparin 88-95 fibronectin 1 Mus musculus 36-38 10852711-7 2000 Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN. Heparin 32-39 fibronectin 1 Mus musculus 86-88 10852711-7 2000 Additionally, both the urea and heparin treatments made the Hep 2 fragment and intact FN much more accessible to the polyclonal antibody (alphaIII14A), with a recognition site near the anti-adhesive site of FN. Heparin 32-39 fibronectin 1 Mus musculus 207-209