PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33263557-9 2021 Moreover, heparin suppresses the ERK response to UAG. Heparin 10-17 mitogen-activated protein kinase 1 Homo sapiens 33-36 24961476-0 2014 Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k/Akt and MEK/ERK signaling pathways in human epidermal keratinocytes. Heparin 0-7 mitogen-activated protein kinase 1 Homo sapiens 121-124 27100626-0 2016 Activation of ERK and NF-kappaB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs. Heparin 53-60 mitogen-activated protein kinase 1 Homo sapiens 14-17 26769966-1 2016 Vascular cell responses to exogenous heparin have been documented to include decreased vascular smooth muscle cell proliferation following decreased ERK pathway signaling. Heparin 37-44 mitogen-activated protein kinase 1 Homo sapiens 149-152 24911927-1 2014 Published data provide strong evidence that heparin treatment of proliferating vascular smooth muscle cells results in decreased signaling through the ERK pathway and decreases in cell proliferation. Heparin 44-51 mitogen-activated protein kinase 1 Homo sapiens 151-154 24911927-5 2014 In addition, protein kinase G inhibitors decrease heparin effects on ERK activity, phosphorylation of the transcription factor Elk-1, and heparin-induced MKP-1 synthesis. Heparin 50-57 mitogen-activated protein kinase 1 Homo sapiens 69-72 24961476-3 2014 Heparin exhibited the inhibitory effect on keratinocyte phagocytosis through blocking PI3k/Akt and MEK/ERK signaling pathways. Heparin 0-7 mitogen-activated protein kinase 1 Homo sapiens 103-106 24961476-4 2014 In fact, the heparin-treated NHEKs showed impaired activation of Akt and ERK during phagocytosis, whereas PI3k and MEK inhibitors significantly suppressed melanosome uptake by NHEKs. Heparin 13-20 mitogen-activated protein kinase 1 Homo sapiens 73-76 21898414-10 2012 In conclusion, the heparin-induced up-regulation of HSPG expression is associated with the phosphorylation of focal adhesion proteins and Ras/Raf/MEK/ERK MAP and Ca(2+) /NO pathways. Heparin 19-26 mitogen-activated protein kinase 1 Homo sapiens 150-153 23571852-0 2013 Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling. Heparin 20-27 mitogen-activated protein kinase 1 Homo sapiens 154-157 23571852-0 2013 Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling. Heparin 28-35 mitogen-activated protein kinase 1 Homo sapiens 154-157 17879163-8 2007 These findings provide evidence that mutations in the high-affinity heparin-binding domain in association with the V region of fibronectin, or altered fibronectin matrices, induce anoikis in human SCC cells by modulating integrin alpha v-mediated phosphorylation of FAK and ERK. Heparin 68-75 mitogen-activated protein kinase 1 Homo sapiens 274-277 22089237-4 2011 We demonstrate that EGFR transactivation and downstream ERK activation depends on increased shedding of heparin-binding EGF. Heparin 104-111 mitogen-activated protein kinase 1 Homo sapiens 56-59 20432446-0 2010 Low-concentration heparin suppresses ionomycin-activated CAMK-II/EGF receptor- and ERK-mediated signaling in mesangial cells. Heparin 18-25 mitogen-activated protein kinase 1 Homo sapiens 83-86 20432446-1 2010 Heparin and endogenous heparinoids inhibit the proliferation of smooth muscle cells, including renal mesangial cells; multiple effects on signaling pathways are well established, including effects on PKC, Erk, and CaMK-II. Heparin 0-7 mitogen-activated protein kinase 1 Homo sapiens 205-208 20432446-5 2010 Low-dose heparin suppresses the ionomycin-dependent phosphorylation of EGFR, c-Src, and Erk 1/2, but not of CaMK-II, whereas inhibition of activated CaMK-II reduces phosphorylation of EGFR, c-Src, and Erk. Heparin 9-16 mitogen-activated protein kinase 1 Homo sapiens 88-91 20432446-6 2010 Our data support a mechanism whereby heparin acts at the cell surface to suppress downstream targets of CaMK-II, including EGFR, leading in turn to a decrease in Erk- (but not c-Src-) dependent induction of c-fos. Heparin 37-44 mitogen-activated protein kinase 1 Homo sapiens 162-165 18292505-0 2008 Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. Heparin 20-27 mitogen-activated protein kinase 1 Homo sapiens 36-39 22026648-3 2012 We found that MEK-ERK signaling is necessary for their cell-cycle entry, and signaling pathways whose activities can be modulated by heparin, such as Wnt-, Shh-, and thrombin-mediated pathways, are capable of regulating the cell-cycle entry. Heparin 133-140 mitogen-activated protein kinase 1 Homo sapiens 18-21 20235148-2 2010 It is clear that heparin treatment can decrease the level of ERK activity in vascular smooth muscle cells that are sensitive to heparin. Heparin 17-24 mitogen-activated protein kinase 1 Homo sapiens 61-64 20235148-2 2010 It is clear that heparin treatment can decrease the level of ERK activity in vascular smooth muscle cells that are sensitive to heparin. Heparin 128-135 mitogen-activated protein kinase 1 Homo sapiens 61-64 20235148-3 2010 In this study, the mechanism by which heparin induces decreases in ERK activity was investigated by evaluating the dual specificity phosphatase, MKP-1, in heparin treated cells. Heparin 38-45 mitogen-activated protein kinase 1 Homo sapiens 67-70 20235148-3 2010 In this study, the mechanism by which heparin induces decreases in ERK activity was investigated by evaluating the dual specificity phosphatase, MKP-1, in heparin treated cells. Heparin 155-162 mitogen-activated protein kinase 1 Homo sapiens 67-70 20235148-8 2010 Blocking either phosphatase activity or synthesis also blocked heparin-induced decreases in ERK activity. Heparin 63-70 mitogen-activated protein kinase 1 Homo sapiens 92-95 20235148-9 2010 Consistent with a role for MKP-1, a nuclear phosphatase, heparin treated cells exhibited decreases in nuclear ERK activity more rapidly than cells not treated with heparin. Heparin 57-64 mitogen-activated protein kinase 1 Homo sapiens 110-113 20235148-10 2010 The data support MKP-1 as a heparin-induced phosphatase that dephosphorylates ERK, decreasing ERK activity, in vascular smooth muscle cells. Heparin 28-35 mitogen-activated protein kinase 1 Homo sapiens 78-81 20235148-10 2010 The data support MKP-1 as a heparin-induced phosphatase that dephosphorylates ERK, decreasing ERK activity, in vascular smooth muscle cells. Heparin 28-35 mitogen-activated protein kinase 1 Homo sapiens 94-97 18240216-6 2008 Antagonizing heparan sulfate side chain formation with beta-xyloside or the addition of soluble heparin prevented ERK activation, in addition to reducing the expression of these proadhesive/contractile proteins. Heparin 96-103 mitogen-activated protein kinase 1 Homo sapiens 114-117 17655843-10 2007 In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation, via an autocrine/paracrine pathway implying MMP activation and heparin-binding-EGF shedding. Heparin 251-258 mitogen-activated protein kinase 1 Homo sapiens 50-53 17226785-9 2007 In these situations, heparin inhibits phosphorylation of EGFR on the Src-dependent site Tyr(845), but not the autophosphorylation of Tyr(1173), and decreases Ras activation and Erk phosphorylation. Heparin 21-28 mitogen-activated protein kinase 1 Homo sapiens 177-180 17226785-10 2007 We conclude that heparin can suppress Erk signaling in VSMC with effects on site-specific phosphorylation of EGFR localized in caveolin-enriched lipid rafts. Heparin 17-24 mitogen-activated protein kinase 1 Homo sapiens 38-41 15785094-7 2005 Western blot analyses indicated that heparin completely blocked extracellular signal-regulated kinase (ERK) activation, and inhibiting ERK activity resulted in loss of heparin-dependent inhibition of the ET-1 gene. Heparin 37-44 mitogen-activated protein kinase 1 Homo sapiens 64-101 17107942-4 2007 Upon PTH stimulation, metalloprotease cleavage of membrane-bound heparin-binding fragment (HB-EGF) induced EGFR transactivation of ERK. Heparin 65-72 mitogen-activated protein kinase 1 Homo sapiens 131-134 16904641-5 2006 The growth-modulating effects of heparin and internalized heparin were dependent on cell surface HSGAGs, PI3K, and Erk/Mek. Heparin 33-40 mitogen-activated protein kinase 1 Homo sapiens 115-118 16904641-5 2006 The growth-modulating effects of heparin and internalized heparin were dependent on cell surface HSGAGs, PI3K, and Erk/Mek. Heparin 58-65 mitogen-activated protein kinase 1 Homo sapiens 115-118 16051824-12 2005 Moderate ERK induction with soluble gB was seen only in HMVEC-d. Preincubation of gpK8.1A with heparin or anti-gpK8.1A antibodies inhibited the ERK induction. Heparin 95-102 mitogen-activated protein kinase 1 Homo sapiens 9-12 16051824-12 2005 Moderate ERK induction with soluble gB was seen only in HMVEC-d. Preincubation of gpK8.1A with heparin or anti-gpK8.1A antibodies inhibited the ERK induction. Heparin 95-102 mitogen-activated protein kinase 1 Homo sapiens 144-147 15785094-7 2005 Western blot analyses indicated that heparin completely blocked extracellular signal-regulated kinase (ERK) activation, and inhibiting ERK activity resulted in loss of heparin-dependent inhibition of the ET-1 gene. Heparin 37-44 mitogen-activated protein kinase 1 Homo sapiens 103-106 15785094-7 2005 Western blot analyses indicated that heparin completely blocked extracellular signal-regulated kinase (ERK) activation, and inhibiting ERK activity resulted in loss of heparin-dependent inhibition of the ET-1 gene. Heparin 168-175 mitogen-activated protein kinase 1 Homo sapiens 135-138 14963717-8 2004 In contrast, the mitogenic effects of the platelet-derived and the heparin-binding epidermal growth factors were dependent on p44/p42 MAPK activation and independent of activation of p38 MAPK. Heparin 67-74 mitogen-activated protein kinase 1 Homo sapiens 134-138 15177934-6 2004 The NT-induced stimulation of EGFR/ERK/Akt phosphorylation and DNA synthesis was inhibited by EGFR-tyrosine kinase inhibitors (AG1478, PD153035), metallo-endopeptidase inhibitor phosphoramidon and by heparin, but not by neutralizing anti-EGF antibody. Heparin 200-207 mitogen-activated protein kinase 1 Homo sapiens 35-38 15620727-4 2005 Heparin also potenciated Ang II-induced activation for ERK1/2 and p38. Heparin 0-7 mitogen-activated protein kinase 1 Homo sapiens 66-69 14963717-8 2004 In contrast, the mitogenic effects of the platelet-derived and the heparin-binding epidermal growth factors were dependent on p44/p42 MAPK activation and independent of activation of p38 MAPK. Heparin 67-74 mitogen-activated protein kinase 1 Homo sapiens 183-186 12948857-6 2003 Decreased Erk activity in the presence of heparin preceded, and may account for, decreased MKP-1. Heparin 42-49 mitogen-activated protein kinase 1 Homo sapiens 10-13 12948857-8 2003 However, because MKP-1 is known to cause an increase in activity of kinases upstream of Erk, that may signal through additional pathways, the decrease in MKP-1 activity may paradoxically enhance heparin"s antiproliferative effects. Heparin 195-202 mitogen-activated protein kinase 1 Homo sapiens 88-91 11848445-8 2002 In summary, the structurally different polysaccharides, heparin, fucoidan (and fucans) have distinguishable effects on mitogenesis and ERK1/ERK2 activation, suggesting that different mechanism(s) mediate these actions. Heparin 56-63 mitogen-activated protein kinase 1 Homo sapiens 140-144 11592962-7 2001 The use of a neutralizing antibody for heparin-binding EGF, one of the ligands of EGFR, blocked TPA-induced phosphorylation of ERKs. Heparin 39-46 mitogen-activated protein kinase 1 Homo sapiens 127-131 10574913-7 1999 Ser(670) is located in a peptide sequence that conforms to an ERK consensus phosphorylation sequence, and in vitro, in the presence of heparin, ERK1 phosphorylates GRK2. Heparin 135-142 mitogen-activated protein kinase 1 Homo sapiens 62-65