PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9846168-1 1998 Heparin affin regulatory peptide (HARP), also named pleiotropin, is a secreted polypeptide that belongs to a new family of heparin-binding growth/differentiation factors. Heparin 123-130 pleiotrophin Rattus norvegicus 0-32 12221095-9 2002 The kinetic constants k(a), k(d), and K(d) suggested that MK, PTN, FGF-16, FGF-18, and HB-EGF bound strongly to CS-E, in comparable degrees to the binding to Hep, whereas the intensity of binding of FGF-2 and FGF-10 toward CS-E was lower than that for Hep. Heparin 158-161 pleiotrophin Rattus norvegicus 62-65 10051750-4 1999 The HB-GAM-induced neurite outgrowth in thalamic neurons was inhibited by heparitinase, heparin, soluble N-syndecan and by an excess of soluble HB-GAM in the culture medium. Heparin 88-95 pleiotrophin Rattus norvegicus 4-10 10051750-7 1999 On the brain slices, the neurite outgrowth was significantly inhibited by heparitinase, heparin and soluble HB-GAM, thus displaying features of neurite outgrowth on matrix-bound HB-GAM. Heparin 88-95 pleiotrophin Rattus norvegicus 178-184 9846168-1 1998 Heparin affin regulatory peptide (HARP), also named pleiotropin, is a secreted polypeptide that belongs to a new family of heparin-binding growth/differentiation factors. Heparin 123-130 pleiotrophin Rattus norvegicus 34-38 8567685-8 1996 Experiments with selectively desulfated heparins indicated that 2-O-sulfated iduronic acid units, in particular, are of importance to the interaction with HB-GAM, were implicated to a lesser extent. Heparin 40-48 pleiotrophin Rattus norvegicus 155-161 8812110-4 1996 The inhibitory effect of HB-GAM on cell proliferation was reversed by heparin, suggesting that HB-GAM may bind to a heparin-type carbohydrate epitope that is required for cell proliferation in the developing limb. Heparin 70-77 pleiotrophin Rattus norvegicus 25-31 8812110-4 1996 The inhibitory effect of HB-GAM on cell proliferation was reversed by heparin, suggesting that HB-GAM may bind to a heparin-type carbohydrate epitope that is required for cell proliferation in the developing limb. Heparin 70-77 pleiotrophin Rattus norvegicus 95-101 8702927-8 1996 Heparin potently inhibited binding of 6B4 proteoglycan to pleiotrophin (IC50 = 3.5 ng/ml). Heparin 0-7 pleiotrophin Rattus norvegicus 58-70 1597470-12 1992 We identified in brain-derived HB-GAM fractions a 17-kDa protein (p17) that is detached from heparin by a slightly higher salt concentration as compared to HB-GAM. Heparin 93-100 pleiotrophin Rattus norvegicus 31-37 8653419-1 1995 The heparin-binding, growth-associated molecule (HB-GAM) is a developmentally regulated protein that belongs to a new family of heparin-binding molecules, not related to the fibroblast growth factors (FGFs), with putative functions during cell growth and differentiation. Heparin 4-11 pleiotrophin Rattus norvegicus 49-55 8653419-13 1995 HB-GAM, which possesses a classical signal sequence, might be release in the extracellular space and could mediate adhesion phenomena by binding to heparin-like molecules associated with the neuronal membrane. Heparin 148-155 pleiotrophin Rattus norvegicus 0-6 7955315-0 1994 Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM. Heparin 22-29 pleiotrophin Rattus norvegicus 14-20 7955315-0 1994 Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM. Heparin 22-29 pleiotrophin Rattus norvegicus 164-170 7955315-11 1994 The interactions of HB-GAM with brain neurons are specifically inhibited by heparin and its fragments and by incubation of the neurons with heparitinase. Heparin 76-83 pleiotrophin Rattus norvegicus 20-26 7955315-12 1994 We suggest that in developing nervous tissues HB-GAM is deposited to an extracellular location in developing axon pathways and it interacts with heparin-like molecules of the neuron surface to promote formation of neural connections. Heparin 145-152 pleiotrophin Rattus norvegicus 46-52 2049182-1 1991 A heparin-binding protein with neurotrophic activity for perinatal rat neurons, termed HBNF, was purified to homogeneity from bovine brain utilizing pH 4.5 extraction, ammonium sulfate precipitation, cation exchange and heparin-Sepharose affinity chromatographies, and reverse phase HPLC. Heparin 2-9 pleiotrophin Rattus norvegicus 87-91 34153666-10 2021 Inhibition of ERK, CREB and interference with PTN expression notably weakened the heparin-mediated neuroprotective effects and restrained the expression of ERK/CREB and PTN/syndecan-3 pathway. Heparin 82-89 pleiotrophin Rattus norvegicus 46-49 34153666-11 2021 CONCLUSION: Heparin attenuates the secondary brain injury induced by CA-CPR through regulating the ERK/CREB-mediated PTN/syndecan-3 pathway. Heparin 12-19 pleiotrophin Rattus norvegicus 117-120 34153666-0 2021 The ERK/CREB/PTN/syndecan-3 pathway involves in heparin-mediated neuro-protection and neuro-regeneration against cerebral ischemia-reperfusion injury following cardiac arrest. Heparin 48-55 pleiotrophin Rattus norvegicus 13-16 34153666-2 2021 Here, we aimed to explore the role of pleiotrophin (PTN)/syndecan-3 pathway in heparin therapy for CIR-CA. Heparin 79-86 pleiotrophin Rattus norvegicus 38-50 34153666-2 2021 Here, we aimed to explore the role of pleiotrophin (PTN)/syndecan-3 pathway in heparin therapy for CIR-CA. Heparin 79-86 pleiotrophin Rattus norvegicus 52-55 34153666-9 2021 In terms of the mechanism, heparin upregulated the expression of ERK, CREB, NF200, BDNF, NGF, PTN and syndecan-3 in the rat brains. Heparin 27-34 pleiotrophin Rattus norvegicus 94-97