PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15969636-7	2005	Phosphoramidon, thiorphan, acidification, and phenanthroline inhibited PM ECE activity; the cytosolic ECE activity was not affected by phenanthroline but was inhibited by the others.	Thiorphan	16-25	endothelin converting enzyme 1	Homo sapiens	74-77	
10433854-8	1999	Treatments with CGS-26303 (100 micrometer), an inhibitor of ECE-1 and thiorphan (2 mM; a metalloprotease inhibitor), significantly decreased ECE-1 activity.	Thiorphan	70-79	endothelin converting enzyme 1	Homo sapiens	141-146	
8615890-5	1996	Unlike E-24.11, however, ECE exists as a disulphide-linked dimer of subunit M(r) 120-130 kDa and is not inhibited by other E-24.11 inhibitors such as thiorphan.	Thiorphan	150-159	endothelin converting enzyme 1	Homo sapiens	25-28	
7864859-2	1995	Metalloendoprotease inhibitors (phosphoramidon and DL-thiorphan), but not captopril, inhibited the contractions elicited by human big ET-1 and big ET-2 but DL-thiorphan was less active, suggesting that a non-selective enzymatic process is involved in conversion of big ET-1 and big ET-2 in addition to a phosphoramidon-sensitive ECE.	Thiorphan	51-63	endothelin converting enzyme 1	Homo sapiens	329-332	
7864859-2	1995	Metalloendoprotease inhibitors (phosphoramidon and DL-thiorphan), but not captopril, inhibited the contractions elicited by human big ET-1 and big ET-2 but DL-thiorphan was less active, suggesting that a non-selective enzymatic process is involved in conversion of big ET-1 and big ET-2 in addition to a phosphoramidon-sensitive ECE.	Thiorphan	156-168	endothelin converting enzyme 1	Homo sapiens	329-332	
8458433-3	1993	The lipoprotein ECE activity, which was optimal at pH 7.0, was inhibited by EDTA, o-phenanthroline, phosphoramidon, thiorphan, phenylmethanesulfonyl fluoride and chymostatin, but not by cysteine or aspartic proteinase inhibitors, suggesting metalloproteinase- and chymotrypsin-like properties.	Thiorphan	116-125	endothelin converting enzyme 1	Homo sapiens	16-19