PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35277468-3	2022	PI(4,5)P2 synthesis is catalyzed by the phosphorylation of phosphatidylinositol 4 phosphate (PI4P) by phosphatidylinositol 4 phosphate 5 kinase (PIP5K).	pi(4,5)p2	0-9	skittles	Drosophila melanogaster	102-143	
35437696-5	2022	Knockdown of Skittles, a phosphatidylinositol(4)phosphate 5-kinase, which produces PI(4,5)P2, abolished slit diaphragm formation and led to strongly reduced endocytosis.	pi(4,5)p2	83-92	skittles	Drosophila melanogaster	25-66	
35277468-3	2022	PI(4,5)P2 synthesis is catalyzed by the phosphorylation of phosphatidylinositol 4 phosphate (PI4P) by phosphatidylinositol 4 phosphate 5 kinase (PIP5K).	pi(4,5)p2	0-9	skittles	Drosophila melanogaster	145-150	
35277468-4	2022	In Drosophila photoreceptors, photon absorption is transduced into PLC activity and during this process, PI(4,5)P2 is resynthesized by a PIP5K.	pi(4,5)p2	105-114	skittles	Drosophila melanogaster	137-142	
35277468-5	2022	However, the mechanism by which PIP5K activity is coupled to PI(4,5)P2 hydrolysis is unknown.	pi(4,5)p2	61-70	skittles	Drosophila melanogaster	32-37	
35277468-8	2022	Thus, our work defines a septin-mediated mechanism through which PIP5K activity is coupled to PLC-mediated PI(4,5)P2 hydrolysis.	pi(4,5)p2	107-116	skittles	Drosophila melanogaster	65-70	
24768049-0	2014	PI(4,5)P2 produced by the PI4P5K SKTL controls apical size by tethering PAR-3 in Drosophila epithelial cells.	pi(4,5)p2	0-9	skittles	Drosophila melanogaster	33-37	
24768049-5	2014	PI(4,5)P2 is essentially regulated by the PI4P5 kinase Skittles (SKTL), whereas neither the phosphatase PTEN nor the PI(4,5)P3 kinase DP110 lead to loss of apical-basal polarity.	pi(4,5)p2	0-9	skittles	Drosophila melanogaster	65-69	
24768049-6	2014	By inactivating SKTL and thereby strongly reducing PI(4,5)P2 levels in a single cell of the epithelium, we observe the disassembly of adherens junctions, actin cytoskeleton reorganization, and apical constriction leading to delamination, a process similar to that observed during epithelial-mesenchymal transition.	pi(4,5)p2	51-60	skittles	Drosophila melanogaster	16-20