PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29359392-5	2018	Recently, we have shown that HBD-3 can enter mammalian cells and bind to inner membrane phosphoinositide 4,5-bisphosphate [PI(4,5)P2], an important second lipid messenger of PLC and PI3K-Akt pathways.	pi(4,5)p2	123-132	AKT serine/threonine kinase 1	Homo sapiens	187-190	
33743346-3	2021	We previously reported that phospholipase C-related catalytically inactive protein (PRIP), a phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] binding protein, regulates PI3K/AKT signaling by competitively inhibiting substrate recognition by PI3K.	pi(4,5)p2	132-141	AKT serine/threonine kinase 1	Homo sapiens	175-178	
33947796-1	2021	The dual-specificity phosphatase PTEN functions as a tumor suppressor by hydrolyzing PI(3,4,5)P3 to PI(4,5)P2 to inhibit PI3K-AKT signaling and cellular proliferation.	pi(4,5)p2	100-109	AKT serine/threonine kinase 1	Homo sapiens	126-129	
32593716-7	2020	Global depletion of PI(4,5)P2 on the cell surface blunted insulin-stimulated Akt phosphorylation and abolished insulin effects in promotion of the docking and fusion of GLUT4 vesicle with the plasma membrane.	pi(4,5)p2	20-29	AKT serine/threonine kinase 1	Homo sapiens	77-80	
30692200-5	2019	A proteomics screen revealed that focal adhesion kinase bound PI(4,5)P2, biochemical assays disclosed that focal adhesion kinase is preferentially activated by weak TCR signals and is required for optimal Treg induction, and further biochemical experiments revealed how TCR signaling strength regulates AKT activation.	pi(4,5)p2	62-71	AKT serine/threonine kinase 1	Homo sapiens	303-306	
29359392-6	2018	In this study, we report that the interaction of HBD-3 with PI(4,5)P2 is important for PI3K-Akt-NF-kappaBeta-mediated induction of tumor necrosis factor and interleukin-6.	pi(4,5)p2	60-69	AKT serine/threonine kinase 1	Homo sapiens	92-95	
26212011-4	2016	We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt.	pi(4,5)p2	29-38	AKT serine/threonine kinase 1	Homo sapiens	154-157	
27601656-0	2016	In B cells, phosphatidylinositol 5-phosphate 4-kinase-alpha synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.	pi(4,5)p2	72-81	AKT serine/threonine kinase 1	Homo sapiens	103-106	
27819060-1	2016	Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P3 from PI(4,5)P2 and the subsequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research.	pi(4,5)p2	64-73	AKT serine/threonine kinase 1	Homo sapiens	107-110	
23443536-0	2013	PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.	pi(4,5)p2	0-9	AKT serine/threonine kinase 1	Homo sapiens	41-44	
24662006-5	2014	The PH domain of AKT (protein kinase B, PKB) (v-AKT murine thymoma viral oncogene homolog) binds to PI(4,5)P2 and PI(3,4,5)P3, followed by phosphorylation of the Thr308 and Ser473 regulatory sites.	pi(4,5)p2	100-109	AKT serine/threonine kinase 1	Homo sapiens	48-51