PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35609603-6 2022 Through reconstitution and epithelial cell biology experiments, we show that Arf6-mediated recruitment of the lipid kinase PIP5K1C rapidly converts phosphatidylinositol 4-phosphate (PI(4)P) to PI(4,5)P2, driving exocyst recruitment and membrane tethering. pi(4,5)p2 193-202 ADP ribosylation factor 6 Homo sapiens 77-81 28634262-6 2017 https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RASSF4) positively influences PI(4,5)P2 synthesis through ARF6-dependent regulation of PIP5K. pi(4,5)p2 119-128 ADP ribosylation factor 6 Homo sapiens 147-151 15465916-8 2004 Strikingly, in cells expressing Arf6/Q67L, Gag was redirected to the PI(4,5)P2-enriched vesicles and HIV-1 virions budded into these vesicles. pi(4,5)p2 69-78 ADP ribosylation factor 6 Homo sapiens 32-36 22869721-7 2012 Consistent with negative regulation of ARF-6 by RAB-10 and CNT-1, we found overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in cnt-1 and rab-10 mutants and reduced endosomal PI(4,5)P2 levels in arf-6 mutants. pi(4,5)p2 144-153 ADP ribosylation factor 6 Homo sapiens 39-44 22869721-7 2012 Consistent with negative regulation of ARF-6 by RAB-10 and CNT-1, we found overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in cnt-1 and rab-10 mutants and reduced endosomal PI(4,5)P2 levels in arf-6 mutants. pi(4,5)p2 144-153 ADP ribosylation factor 6 Homo sapiens 225-230 22869721-7 2012 Consistent with negative regulation of ARF-6 by RAB-10 and CNT-1, we found overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in cnt-1 and rab-10 mutants and reduced endosomal PI(4,5)P2 levels in arf-6 mutants. pi(4,5)p2 205-214 ADP ribosylation factor 6 Homo sapiens 39-44 22869721-9 2012 Our studies identify a RAB-10-to-ARF-6 regulatory loop required to regulate endosomal PI(4,5)P2, a key phosphoinositide in membrane traffic. pi(4,5)p2 86-95 ADP ribosylation factor 6 Homo sapiens 33-38 11273133-5 2000 Particle motility induced by ARF6 involved Arp2/3 complex, tyrosine kinase activity, phospholipase D (PLD) and D3-phosphoinositides, but not phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). pi(4,5)p2 180-189 ADP ribosylation factor 6 Homo sapiens 29-33