PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33174050-7 2020 Immunofluorescence analysis revealed that SFN attenuated the production of poly(I:C)-induced nuclear translocation of the NF-kappaB p65 subunit. Poly I-C 75-84 RELA proto-oncogene, NF-kB subunit Homo sapiens 122-135 33332692-6 2021 To further elucidate the poly IC-induced signaling pathway, the cells were applied to RNA interference against IFN-beta, nuclear factor (NF)-kappaB p65, and IFN regulatory factor (IRF) 3. Poly I-C 25-32 RELA proto-oncogene, NF-kB subunit Homo sapiens 121-151 30508574-4 2019 N3 PUFAs (DHA 8.7 muM/EPA14.21 muM) or clozapine (3 muM) significantly reduced poly I:C-induced increase in iNOS, NFkB (p50/p65), IL-6 and nitrite when compared to non-treated cells. Poly I-C 79-87 RELA proto-oncogene, NF-kB subunit Homo sapiens 124-127 29959281-6 2018 Specifically, the response to poly I:C (mimicking viral dsRNA and signaling through TLR3) induced a distinct RELA profile, binding in the vicinity of antiviral genes and correlating with corresponding gene expression. Poly I-C 30-38 RELA proto-oncogene, NF-kB subunit Homo sapiens 109-113 26141411-4 2015 ECTV interfered with p65 NF-kappaB nuclear translocation induced by TLR ligands such as lipopolysaccharide (LPS) (TLR4), polyinosinic-polycytidylic acid (poly(I:C)) (TLR3) and diacylated lipopeptide Pam2CSK4 (TLR2/6). Poly I-C 121-152 RELA proto-oncogene, NF-kB subunit Homo sapiens 21-24 28778400-10 2017 LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways. Poly I-C 7-15 RELA proto-oncogene, NF-kB subunit Homo sapiens 25-28 28778400-10 2017 LPS or poly(I:C) induced p65 translocation and phosphorylation of IkappaBalpha, p65, p38, and JNK were suppressed by GC31.GC31 is not only an effective inhibitor of LPS-induced inflammatory response, but it also inhibits poly(I:C)-induced release of inflammatory cytokines and ICAM-1 expression by blocking the NF-kappaB and MAPK (p38 and JNK) pathways. Poly I-C 7-15 RELA proto-oncogene, NF-kB subunit Homo sapiens 80-83 28052863-7 2017 Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C). Poly I-C 222-230 RELA proto-oncogene, NF-kB subunit Homo sapiens 146-149 28052863-10 2017 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C 122-131 RELA proto-oncogene, NF-kB subunit Homo sapiens 0-13 28052863-10 2017 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C 122-131 RELA proto-oncogene, NF-kB subunit Homo sapiens 10-13 28052863-10 2017 NF-kappaB p65 intranuclear translocation induced by the TLR4 agonist was reduced by inhibition of p50 migration; however, poly(I:C)-induced p65 translocation was not, although the p65/p50 heterodimer is present in AVICs. Poly I-C 122-131 RELA proto-oncogene, NF-kB subunit Homo sapiens 140-143 28150518-6 2017 Knockdown of p65 inhibited the poly IC-induced IFN-beta expression, and chloroquine pretreatment decreased the nuclear poly IC-induced translocation of NF-kappaB p65 in MCs. Poly I-C 31-38 RELA proto-oncogene, NF-kB subunit Homo sapiens 13-16 23944933-4 2014 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C 20-27 RELA proto-oncogene, NF-kB subunit Homo sapiens 260-263 23534905-8 2013 Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or nuclear factor kappa B (NF-kappaB) inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and also suppressed IL-32 production induced by polyI:C or flagellin. Poly I-C 215-222 RELA proto-oncogene, NF-kB subunit Homo sapiens 132-135 21501152-10 2011 Among NF-kappaB subunits, p65 and p50 were activated by poly I:C stimulation and accumulated in the nucleus. Poly I-C 56-64 RELA proto-oncogene, NF-kB subunit Homo sapiens 26-29 22750548-6 2012 Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells. Poly I-C 17-25 RELA proto-oncogene, NF-kB subunit Homo sapiens 106-118 22750548-6 2012 Combined CD3 and poly(I:C) stimulation significantly enhanced the transcription of IRF7 and additionally, NF-kappaBp65 phosphorylation, which might be involved in the induction of antiviral chemokines and the enhanced cytotoxic activity of poly(I:C)-treated CD4 T cells. Poly I-C 240-248 RELA proto-oncogene, NF-kB subunit Homo sapiens 106-118 21684348-8 2011 Interestingly, IkappaB-alpha inhibitor (BAY11-7082) or NF-kappaB inhibitor (quinazoline) blocked NF-kappaB p65 protein nuclear translocation, and suppressed IL-33 production induced by PolyI:C and flagellin. Poly I-C 185-192 RELA proto-oncogene, NF-kB subunit Homo sapiens 97-110 21501152-11 2011 Activation of the p65 subunit was investigated further by determining its phosphorylation status, which revealed that poly I:C stimulation resulted in prolonged phosphorylation of p65. Poly I-C 118-126 RELA proto-oncogene, NF-kB subunit Homo sapiens 18-21 21501152-11 2011 Activation of the p65 subunit was investigated further by determining its phosphorylation status, which revealed that poly I:C stimulation resulted in prolonged phosphorylation of p65. Poly I-C 118-126 RELA proto-oncogene, NF-kB subunit Homo sapiens 180-183 7636259-7 1995 Our studies indicate that MV, TNF-alpha, or PIPC induces NF-kappa B (p50 and p65 subunits) binding to positive regulatory domain II in the glioma cell line. Poly I-C 44-48 RELA proto-oncogene, NF-kB subunit Homo sapiens 77-80 19151401-10 2009 PolyI:C, flagellin, or TNF-alpha also induced NF-kappaB p65 protein nuclear translocation. Poly I-C 0-7 RELA proto-oncogene, NF-kB subunit Homo sapiens 56-59 18541719-6 2008 Moreover, mf interfered with NF-kappaB activation (particularly p65 and p50) following stimulation with poly I:C or LPS. Poly I-C 104-112 RELA proto-oncogene, NF-kB subunit Homo sapiens 64-67 34497658-10 2021 LBO could also effectively downregulate the expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interferon-beta and the activation of P65 and IRF3 in Poly I:C-treated cells. Poly I-C 168-176 RELA proto-oncogene, NF-kB subunit Homo sapiens 152-155