PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23169223-5 2012 RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-gamma-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-beta promoter stimulator-1-KO, and TLR4-KO mice. Poly I-C 14-53 TIR domain containing adaptor molecule 1 Homo sapiens 358-362 23850521-5 2013 Moreover, inhibitory effects of TLR3 on beta-cell growth were supported by gene silencing of TRIF, which could inhibit p38 activity in response to poly (I:C) stimuli. Poly I-C 147-156 TIR domain containing adaptor molecule 1 Homo sapiens 93-97 23534905-7 2013 The polyI:C-induced IL-32 production was blocked by TLR3 antibody or TRIF inhibitory peptide, while flagellin-stimulated IL-32 was blocked by TLR5 antibody or MyD88 inhibitory peptide. Poly I-C 4-11 TIR domain containing adaptor molecule 1 Homo sapiens 69-73 21926109-4 2011 Although, TRIF-mediated signal inducers, lipopolysaccharide or poly (I:C), induced high level of extracellular signal-regulated kinase (ERK)-1/2 mitogen-activated protein kinase (MAPK) phosphorylation, but they were failed to induce significant p38MAPK phosphorylation in TAM. Poly I-C 63-72 TIR domain containing adaptor molecule 1 Homo sapiens 10-14 21964925-3 2012 Here, we report that poly(I:C) stimulation induces selective autophagic degradation of the TLR adaptor molecule TRIF and the signaling molecule TRAF6, which is revealed by gene silencing of the ubiquitin-editing enzyme A20. Poly I-C 21-30 TIR domain containing adaptor molecule 1 Homo sapiens 112-116 21697465-10 2011 TRIF silencing reduced poly(I C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I C)-induced apoptosis. Poly I-C 23-34 TIR domain containing adaptor molecule 1 Homo sapiens 0-4 21931545-3 2011 Here, we show that HAV also disrupts TLR3 signaling, inhibiting poly(I:C)-stimulated dimerization of IFN regulatory factor 3 (IRF-3), IRF-3 translocation to the nucleus, and IFN-beta promoter activation, by targeting TRIF for degradation by a distinct 3ABCD processing intermediate, the 3CD protease-polymerase precursor. Poly I-C 64-73 TIR domain containing adaptor molecule 1 Homo sapiens 217-221 21684348-7 2011 The PolyI:C induced IL-33 production was blocked by TLR3 antibody or TRIF Inhibitory peptide, while flagellin stimulated IL-33 was blocked by TLR5 antibody or MyD88 Inhibitory peptide. Poly I-C 4-11 TIR domain containing adaptor molecule 1 Homo sapiens 69-73 21697465-10 2011 TRIF silencing reduced poly(I C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I C)-induced apoptosis. Poly I-C 23-34 TIR domain containing adaptor molecule 1 Homo sapiens 121-125 21697465-10 2011 TRIF silencing reduced poly(I C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I C)-induced apoptosis. Poly I-C 141-152 TIR domain containing adaptor molecule 1 Homo sapiens 0-4 21697465-10 2011 TRIF silencing reduced poly(I C)-triggered caspase 8 activation in mock- and ICP6Delta-infected cells, confirming that TRIF is involved in poly(I C)-induced apoptosis. Poly I-C 141-152 TIR domain containing adaptor molecule 1 Homo sapiens 121-125 21148036-6 2011 RNA interference experiments demonstrated that poly (I:C)-induced sTNFR1 shedding is mediated via activation of TLR3-TRIF-RIP1 signaling, with subsequent activation of two downstream pathways. Poly I-C 47-57 TIR domain containing adaptor molecule 1 Homo sapiens 117-121 20957750-9 2010 Our findings offer a new mechanistic insight into TLR3/TRIF signalling through a hitherto unknown mechanism whereby Mal inhibits poly(I:C)-induced IRF7 activation and concomitant IFN-beta production. Poly I-C 129-138 TIR domain containing adaptor molecule 1 Homo sapiens 55-59 20019748-4 2010 Instead, poly I:C-induced activation of caspase-8 via TLR3 and its adapter TRIF was required for apoptosis. Poly I-C 9-17 TIR domain containing adaptor molecule 1 Homo sapiens 75-79 16115877-2 2005 Cytokine production is impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Rip1 in the Trif-dependent TLR3 and TLR4 pathways. Poly I-C 79-88 TIR domain containing adaptor molecule 1 Homo sapiens 137-141 20200155-8 2010 Finally, we demonstrated that TRIS was associated with TRIF upon TLR3 activation by poly(I-C). Poly I-C 84-93 TIR domain containing adaptor molecule 1 Homo sapiens 55-59 19635904-9 2009 Taken together, poly I:C activates the IPS-1- and TRIF-dependent pathways in CD8alpha(+) cDCs, which in turn leads to NK cell activation. Poly I-C 16-24 TIR domain containing adaptor molecule 1 Homo sapiens 50-54 19635904-0 2009 Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Poly I-C 0-8 TIR domain containing adaptor molecule 1 Homo sapiens 88-92 19635904-6 2009 Furthermore, both IPS-1 and TRIF contributed to suppression of implanted B16 tumor growth in response to poly I:C administration via NK cell activation. Poly I-C 105-113 TIR domain containing adaptor molecule 1 Homo sapiens 28-32 19635904-7 2009 Presence of IPS-1 and TRIF in dendritic cells (DCs), but not NK cells, was required for production of IFN-gamma to poly I:C in NK cells in vitro. Poly I-C 115-123 TIR domain containing adaptor molecule 1 Homo sapiens 22-26 19304544-6 2009 The mRNA level of TLR3, TRIF, and IFN-beta were also increased following Poly I:C treatment in comparison with the control group. Poly I-C 73-81 TIR domain containing adaptor molecule 1 Homo sapiens 24-28 26418032-9 2015 Collectively, these findings indicate that IL-17A and TLR3 activation cooperate to induce proinflammatory responses in the airway epithelium via TLR3/TRIF-mediated NF-kappaB/IRF3 activation, and that enhanced activation of the NF-kappaB pathway plays an essential role in synergistic induction after co-treatment with IL-17A and polyI:C in vitro. Poly I-C 329-336 TIR domain containing adaptor molecule 1 Homo sapiens 150-154 35443313-10 2022 Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg. Poly I-C 13-21 TIR domain containing adaptor molecule 1 Homo sapiens 40-44 35443313-10 2022 Conclusions: Poly I:C can activate TLR3/TRIF/NF-kappaB and TLR3/TRIF/IRF3 signaling pathway, promote the function of downstream signaling molecules, and then promote the maturation of DC, induce the immune responses of CD4+T cell, and promote the maturation and activation of B cells and the immune response of rHBsAg. Poly I-C 13-21 TIR domain containing adaptor molecule 1 Homo sapiens 64-68 28717003-5 2017 In response to poly(I:C) addition, the metastatic IECs also induced the chemokine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta. Poly I-C 15-24 TIR domain containing adaptor molecule 1 Homo sapiens 101-105 29505789-6 2018 We examined the mechanisms underlying these effects, with poly I:C significantly reducing peak sodium current, an effect dependent on the MyD88-independent TRIF dependent pathway. Poly I-C 58-66 TIR domain containing adaptor molecule 1 Homo sapiens 156-160 28052863-7 2017 Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF) suppressed ERK1/2 and NF-kappaB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:C). Poly I-C 222-230 TIR domain containing adaptor molecule 1 Homo sapiens 108-112 28052863-11 2017 Poly(I:C) upregulates the production of multiple inflammatory mediators through the TLR3-TRIF-NF-kappaB pathway in human AVICs. Poly I-C 0-8 TIR domain containing adaptor molecule 1 Homo sapiens 89-93 27834952-8 2017 Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs. Poly I-C 31-38 TIR domain containing adaptor molecule 1 Homo sapiens 58-65 24693944-0 2014 MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN-beta (TRIF) recruitment to Toll-like receptor 3. Poly I-C 56-63 TIR domain containing adaptor molecule 1 Homo sapiens 150-154 23944933-4 2014 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C 20-27 TIR domain containing adaptor molecule 1 Homo sapiens 176-180 24014881-3 2014 After poly(I:C) administration, a rapid reduction in parasite burden was observed and proved to be dependent on CD11c(+) cells and TLR3/TRIF signaling. Poly I-C 6-15 TIR domain containing adaptor molecule 1 Homo sapiens 136-140 23944933-4 2014 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C 335-342 TIR domain containing adaptor molecule 1 Homo sapiens 176-180 23944933-4 2014 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C 20-27 TIR domain containing adaptor molecule 1 Homo sapiens 208-212 23944933-4 2014 IL-17C induction by polyI:C was both time dependent and dose dependent, and was attenuated by inhibitors of the Toll-IL-1 receptor domain-containing adaptor-inducing INF-beta (TRIF)-NF-kappaB pathway, Pepinh-TRIF, BAY11, NF-kappaB inhibitor III, and NF-kappaB p65 small interfering RNA, suggesting that IL-17C expression is induced by polyI:C via the Toll-like receptor 3-TRIF-NF-kappaB pathway. Poly I-C 20-27 TIR domain containing adaptor molecule 1 Homo sapiens 208-212 24080550-4 2013 To evaluate the therapeutic potential of NVPP, its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid (poly[I:C]) was examined. Poly I-C 159-190 TIR domain containing adaptor molecule 1 Homo sapiens 89-93