PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18288958-4 2008 P-gp regulated the translocation of sphingomyelin (SM) and GlcCer, and short chain C(6)-NBD-GlcCer was found in the apical medium of P-gp cells exclusively and not in the basolateral membrane. Glucosylceramides 59-65 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 18003606-3 2008 MDR1 is also a translocase that flips glucosylceramide inside the Golgi to enhance neutral glycosphingolipid (GSL) synthesis. Glucosylceramides 38-54 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19285492-2 2009 Inhibition of glucosylceramide (GC) synthesis has been shown in cell lines to correlate with the expression and function of P-gp and sensitise cancer cells to cytotoxic agents. Glucosylceramides 14-30 ATP binding cassette subfamily B member 1 Homo sapiens 124-128 19285492-2 2009 Inhibition of glucosylceramide (GC) synthesis has been shown in cell lines to correlate with the expression and function of P-gp and sensitise cancer cells to cytotoxic agents. Glucosylceramides 32-34 ATP binding cassette subfamily B member 1 Homo sapiens 124-128 15661399-2 2005 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides 76-92 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 15799713-0 2005 The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. Glucosylceramides 73-89 ATP binding cassette subfamily B member 1 Homo sapiens 18-32 15799713-3 2005 Pgp has been shown to translocate fluorescent phospholipids, and it has been suggested that it may also interact with GlcCer (glucosylceramide). Glucosylceramides 118-124 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 15799713-3 2005 Pgp has been shown to translocate fluorescent phospholipids, and it has been suggested that it may also interact with GlcCer (glucosylceramide). Glucosylceramides 126-142 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 15661399-16 2005 CONCLUSION: Our data suggests that ceramide induces apoptosis in AML cells and that p-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway making a marked contribution to this resistance in TF-1 cells. Glucosylceramides 171-187 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 18035065-0 2007 Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells. Glucosylceramides 13-29 ATP binding cassette subfamily B member 1 Homo sapiens 85-89 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 100-116 ATP binding cassette subfamily B member 1 Homo sapiens 139-143 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 100-116 ATP binding cassette subfamily B member 1 Homo sapiens 190-204 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 100-116 ATP binding cassette subfamily B member 1 Homo sapiens 206-210 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 100-116 ATP binding cassette subfamily B member 1 Homo sapiens 261-265 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 118-120 ATP binding cassette subfamily B member 1 Homo sapiens 139-143 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 118-120 ATP binding cassette subfamily B member 1 Homo sapiens 190-204 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 118-120 ATP binding cassette subfamily B member 1 Homo sapiens 206-210 18035065-1 2007 In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Glucosylceramides 118-120 ATP binding cassette subfamily B member 1 Homo sapiens 261-265 15661399-2 2005 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides 76-92 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 15661399-2 2005 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides 94-96 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 15661399-2 2005 P-glycoprotein (p-gp) might augment ceramide glycosylation by translocating glucosylceramide (GC) across the Golgi membrane. Glucosylceramides 94-96 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Glucosylceramides 203-219 ATP binding cassette subfamily B member 1 Homo sapiens 37-51 14662772-1 2004 Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi complex (Lala, P., Ito, S., and Lingwood, C. A. Glucosylceramides 83-100 ATP binding cassette subfamily B member 1 Homo sapiens 72-76 14662772-7 2004 Microsomal lactosyl ceramide and globotriaosyl ceramide synthesis from endogenous or exogenously added liposomal glucosyl ceramide was inhibited by cyclosporin A, consistent with a direct role for MDR1/glucosyl ceramide translocase activity in their synthesis. Glucosylceramides 113-130 ATP binding cassette subfamily B member 1 Homo sapiens 197-201 12467215-10 2002 Given the intracellular distribution patterns of Pgp, we propose that this effect is related to glucosylceramide translocation across the Golgi bilayer. Glucosylceramides 96-112 ATP binding cassette subfamily B member 1 Homo sapiens 49-52 15122583-1 2004 Previously we have described a novel multidrug-resistant cell line, HT29(col), which displayed over expression of the multidrug-resistance protein 1 (MRP1) and an altered sphingolipid composition, including enhanced levels of glucosylceramide (GlcCer; Kok JW, Veldman RJ, Klappe K, Koning H, Filipeanu C, Muller M. Int J Cancer 2000;87:172-8). Glucosylceramides 244-250 ATP binding cassette subfamily B member 1 Homo sapiens 150-154 15122583-12 2004 In conclusion, upregulation of MRP1 occurs in concert with upregulation of GlcCer during multidrug-resistance acquisition, and both are enriched in rafts. Glucosylceramides 75-81 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 30237856-4 2018 By comparing parental MEC-2 cells, a human CLL cell line, we found that flu-resistant clonal cells were significantly increased lethal dose 50 of flu concentration, and up-regulated expression of P-glycoprotein, a drug-resistant marker, glucosylceramide synthase (GCS), an enzyme that can convert ceramide to glucosylceramide, and CD34, a leukemia stem cell marker. Glucosylceramides 237-253 ATP binding cassette subfamily B member 1 Homo sapiens 196-210 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Glucosylceramides 203-219 ATP binding cassette subfamily B member 1 Homo sapiens 53-56 27693344-1 2017 It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette (ABC) transporter, can transport phospholipids such as phosphatidylcholine, -ethanolamine and -serine as well as glucosylceramide and glycosphingolipids. Glucosylceramides 203-219 ATP binding cassette subfamily B member 1 Homo sapiens 58-63