PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34686867-3 2021 Here, we uncover that tumor-cell-derived glucosylceramide stimulated unconventional endoplasmic reticulum (ER) stress responses by inducing reshuffling of lipid composition and saturation on the ER membrane in macrophages, which induced IRE1-mediated spliced XBP1 production and STAT3 activation. Glucosylceramides 41-57 X-box binding protein 1 Homo sapiens 259-263