PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2505889-4 1989 Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. 1,2-Dipalmitoylphosphatidylcholine 198-202 insulin Homo sapiens 50-57 11292539-6 2001 A significantly higher blood glucose decrease was observed with a DPPC-insulin physical mixture compared to liposome, suggesting a possible effect of the phospholipid chain physical state on the insulin in-vivo absorption. 1,2-Dipalmitoylphosphatidylcholine 66-70 insulin Homo sapiens 71-78 11292539-6 2001 A significantly higher blood glucose decrease was observed with a DPPC-insulin physical mixture compared to liposome, suggesting a possible effect of the phospholipid chain physical state on the insulin in-vivo absorption. 1,2-Dipalmitoylphosphatidylcholine 66-70 insulin Homo sapiens 195-202 12567917-0 2000 [Interactions of insulin with dipalmitoylphosphatidylcholine liposomes]. 1,2-Dipalmitoylphosphatidylcholine 30-60 insulin Homo sapiens 17-24 12567917-1 2000 AIM: To study the interactions of insulin with dipalmitoylphosphatidylcholine liposomes. 1,2-Dipalmitoylphosphatidylcholine 47-77 insulin Homo sapiens 34-41 12567917-6 2000 The insertion of tyrosine of insulin into dipalmitoylphosphatidylcholine liposomes membrane was not deep. 1,2-Dipalmitoylphosphatidylcholine 42-72 insulin Homo sapiens 29-36 2505889-2 1989 Surface potential (delta V) measurements were performed to assess information on insulin penetration/interaction with dipalmitoylphosphatidylcholine (DPPC) monolayers spread at the water-air interface. 1,2-Dipalmitoylphosphatidylcholine 118-148 insulin Homo sapiens 81-88 2505889-2 1989 Surface potential (delta V) measurements were performed to assess information on insulin penetration/interaction with dipalmitoylphosphatidylcholine (DPPC) monolayers spread at the water-air interface. 1,2-Dipalmitoylphosphatidylcholine 150-154 insulin Homo sapiens 81-88 2505889-4 1989 Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. 1,2-Dipalmitoylphosphatidylcholine 87-91 insulin Homo sapiens 50-57 2505889-4 1989 Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. 1,2-Dipalmitoylphosphatidylcholine 198-202 insulin Homo sapiens 50-57 2505889-4 1989 Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. 1,2-Dipalmitoylphosphatidylcholine 198-202 insulin Homo sapiens 50-57 2505889-4 1989 Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. 1,2-Dipalmitoylphosphatidylcholine 198-202 insulin Homo sapiens 50-57 21702369-0 2011 Chemical stability and cytotoxicity of human insulin loaded in cationic DPPC/CTA/DDAB liposomes. 1,2-Dipalmitoylphosphatidylcholine 72-76 insulin Homo sapiens 45-52 21702369-6 2011 The synthesized cationic lipid, CTA, and the DPPC/Chol/CTA liposomes loaded with human insulin demonstrated no cytotoxicity on normal human skin fibroblast but some cytotoxic effects on mouth epidermal cancer cell line. 1,2-Dipalmitoylphosphatidylcholine 45-49 insulin Homo sapiens 87-94 21702369-7 2011 This study has demonstrated the enhancement of chemical stability of human insulin with no cytotoxicity when loaded this protein in cationic DPPC/CTA/DDAB liposomes. 1,2-Dipalmitoylphosphatidylcholine 141-145 insulin Homo sapiens 75-82 6991910-1 1980 The interaction between dipalmitoyl lecithin and egg lecithin with insulin was studied in a non-aqueous solvent such as dioxane-chloroform (1:1) by dielectric constant measurements and absorption spectra. 1,2-Dipalmitoylphosphatidylcholine 24-44 insulin Homo sapiens 67-74 3517295-3 1986 The fusion and aggregation properties of dipalmitoylphosphatidylcholine (DPPC) small, unilamellar liposomes, on the binding of insulin was studied by the techniques of resonance energy transfer of fluorescent labeled lipids, electron microscopy, and right-angle scattering. 1,2-Dipalmitoylphosphatidylcholine 41-71 insulin Homo sapiens 127-134 3517295-3 1986 The fusion and aggregation properties of dipalmitoylphosphatidylcholine (DPPC) small, unilamellar liposomes, on the binding of insulin was studied by the techniques of resonance energy transfer of fluorescent labeled lipids, electron microscopy, and right-angle scattering. 1,2-Dipalmitoylphosphatidylcholine 73-77 insulin Homo sapiens 127-134 3517295-4 1986 Within 1 h of adding insulin to DPPC liposomes at 25 degrees C, the average size of the liposomes increased from 239 to 361 A in diameter. 1,2-Dipalmitoylphosphatidylcholine 32-36 insulin Homo sapiens 21-28 22975396-3 2012 The interaction of glucose, insulin, and a mixture of glucose and insulin to the DPPC monolayer were investigated via surface pressure-area per molecule Langmuir isotherms and fluorescence microscopy. 1,2-Dipalmitoylphosphatidylcholine 81-85 insulin Homo sapiens 28-35 22975396-3 2012 The interaction of glucose, insulin, and a mixture of glucose and insulin to the DPPC monolayer were investigated via surface pressure-area per molecule Langmuir isotherms and fluorescence microscopy. 1,2-Dipalmitoylphosphatidylcholine 81-85 insulin Homo sapiens 66-73 28689439-0 2017 Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin. 1,2-Dipalmitoylphosphatidylcholine 27-58 insulin Homo sapiens 104-111 28689439-1 2017 OBJECTIVE: We have previously shown that aerosolized liposomes with dipalmitoyl phosphatidylcholine (DPPC) enhance the pulmonary absorption of encapsulated insulin. 1,2-Dipalmitoylphosphatidylcholine 68-99 insulin Homo sapiens 156-163 28689439-1 2017 OBJECTIVE: We have previously shown that aerosolized liposomes with dipalmitoyl phosphatidylcholine (DPPC) enhance the pulmonary absorption of encapsulated insulin. 1,2-Dipalmitoylphosphatidylcholine 101-105 insulin Homo sapiens 156-163 28689439-6 2017 RESULTS: DPPC liposomes enhanced the pulmonary absorption of unencapsulated free insulin; however, the enhancing effect was lower than that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine 9-13 insulin Homo sapiens 81-88 28689439-7 2017 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine 76-80 insulin Homo sapiens 65-72 28689439-7 2017 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine 76-80 insulin Homo sapiens 238-245 28689439-7 2017 The mechanism of the pulmonary absorption of unencapsulated free insulin by DPPC liposomes involved the opening of epithelial cell space in alveolar mucosa, and not mucosal cell damage, similar to that of the DPPC liposomes encapsulating insulin. 1,2-Dipalmitoylphosphatidylcholine 209-213 insulin Homo sapiens 65-72 28689439-9 2017 These findings suggest that, although unencapsulated free insulin spreads throughout the alveolar mucus layer, the concentration of insulin released near the absorption surface is increased by the encapsulation of insulin into DPPC liposomes and the absorption efficiency is also increased. 1,2-Dipalmitoylphosphatidylcholine 227-231 insulin Homo sapiens 132-139 28689439-9 2017 These findings suggest that, although unencapsulated free insulin spreads throughout the alveolar mucus layer, the concentration of insulin released near the absorption surface is increased by the encapsulation of insulin into DPPC liposomes and the absorption efficiency is also increased. 1,2-Dipalmitoylphosphatidylcholine 227-231 insulin Homo sapiens 132-139 28689439-10 2017 CONCLUSION: We revealed that the encapsulation of insulin into DPPC liposomes is more effective for pulmonary insulin absorption than co-administration of DPPC liposomes and unencapsulated free insulin. 1,2-Dipalmitoylphosphatidylcholine 63-67 insulin Homo sapiens 50-57 28689439-10 2017 CONCLUSION: We revealed that the encapsulation of insulin into DPPC liposomes is more effective for pulmonary insulin absorption than co-administration of DPPC liposomes and unencapsulated free insulin. 1,2-Dipalmitoylphosphatidylcholine 63-67 insulin Homo sapiens 110-117 26624532-0 2016 Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air/water interface. 1,2-Dipalmitoylphosphatidylcholine 89-119 insulin Homo sapiens 76-83 26624532-4 2016 Below 20mN/m Insulin forms stable homogenous films with DPPC and POPC at all mole fractions studied (except for films with XINS=0.05 at 10mN/m where domain coexistence was observed). 1,2-Dipalmitoylphosphatidylcholine 56-60 insulin Homo sapiens 13-20 26624532-7 2016 The spontaneously unfavorable interactions of Insulin with DPPC are driven by favorable enthalpy that is overcome by unfavorable entropic ordering; in films with POPC both the enthalpic and entropic effects are unfavorable. 1,2-Dipalmitoylphosphatidylcholine 59-63 insulin Homo sapiens 46-53 22975396-5 2012 The presence of a mixture of insulin and glucose affected the molecular packing in the DPPC monolayer differently than the pure insulin or glucose solutions, and the glucose-insulin mixture was seen to be able to penetrate through the monolayer. 1,2-Dipalmitoylphosphatidylcholine 87-91 insulin Homo sapiens 29-36