PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33002451-5 2021 We used a combination of experimental and computer simulation techniques to clarify molecular details of bee venom PLA2 interaction with lipid bilayers formed by palmitoyloleoylphosphatidylcholine or dipalmitoylphosphatidylcholine. 1,2-Dipalmitoylphosphatidylcholine 200-230 phospholipase A2 group IB Homo sapiens 115-119 27865984-2 2017 We report that a hybrid liposome composed of phospholipid (DPPC) and PEGylated block-copolymer (Poloxamer 188) can rapidly release an encapsulated hydrophilic drug in the presence of PLA2. 1,2-Dipalmitoylphosphatidylcholine 59-63 phospholipase A2 group IB Homo sapiens 183-187 27865984-7 2017 These findings suggest that DPPC/P188 liposomes are a promising drug carrier for delivering drug efficiently at PLA2-expressing sites such as inflammatory lung cancer. 1,2-Dipalmitoylphosphatidylcholine 28-32 phospholipase A2 group IB Homo sapiens 112-116 29371621-6 2018 Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with sn-1 and sn-2 ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both sn-1 and sn-2 ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2) cleavage. 1,2-Dipalmitoylphosphatidylcholine 276-280 phospholipase A2 group IB Homo sapiens 356-372 27865984-3 2017 DPPC/P188 liposomes released approximately 80% of the encapsulated calcein (a fluorescence marker) within 10min in the presence of 120 mU of PLA2 at 37 C in vitro, whereas several other liposomal compositions used for inhalation therapy did not. 1,2-Dipalmitoylphosphatidylcholine 0-4 phospholipase A2 group IB Homo sapiens 141-145 27865984-4 2017 DPPC/P188 liposomes were stable in the absence of PLA2 at 37 C after 60min incubation and drug release by PLA2 was dependent on the amount of P188 incorporated into the DPPC liposomes. 1,2-Dipalmitoylphosphatidylcholine 0-4 phospholipase A2 group IB Homo sapiens 106-110 27865984-4 2017 DPPC/P188 liposomes were stable in the absence of PLA2 at 37 C after 60min incubation and drug release by PLA2 was dependent on the amount of P188 incorporated into the DPPC liposomes. 1,2-Dipalmitoylphosphatidylcholine 169-173 phospholipase A2 group IB Homo sapiens 106-110 27865984-5 2017 Drug release from doxorubicin (DOX, anticancer drug)-loaded DPPC/P188 liposomes was facilitated at higher PLA2 concentrations and was dependent on the temperature and the presence of calcium ion, thus partially explaining PLA2-responsive drug release. 1,2-Dipalmitoylphosphatidylcholine 60-64 phospholipase A2 group IB Homo sapiens 106-110 27865984-5 2017 Drug release from doxorubicin (DOX, anticancer drug)-loaded DPPC/P188 liposomes was facilitated at higher PLA2 concentrations and was dependent on the temperature and the presence of calcium ion, thus partially explaining PLA2-responsive drug release. 1,2-Dipalmitoylphosphatidylcholine 60-64 phospholipase A2 group IB Homo sapiens 222-226 23727005-8 2013 Specifically, the rate of PLA2 hydrolysis of the coumarin labeled phosphatidylcholine analogs was less than three times slower than the natural substrate dipalmitoyl phosphatidylcholine (DPPC) under the same experimental conditions. 1,2-Dipalmitoylphosphatidylcholine 154-185 phospholipase A2 group IB Homo sapiens 26-30 26855469-1 2016 After an hour contact with a phospholipase A2 (PLA2) solution, only the outer leaflet of the dipalmitoylphosphatidylcholine (DPPC) bilayers supported on mica surface underwent hydrolysis whose products, i.e., palmitic acid and lysophospholipid, accumulated on the bilayer surface. 1,2-Dipalmitoylphosphatidylcholine 93-123 phospholipase A2 group IB Homo sapiens 29-45 26855469-1 2016 After an hour contact with a phospholipase A2 (PLA2) solution, only the outer leaflet of the dipalmitoylphosphatidylcholine (DPPC) bilayers supported on mica surface underwent hydrolysis whose products, i.e., palmitic acid and lysophospholipid, accumulated on the bilayer surface. 1,2-Dipalmitoylphosphatidylcholine 93-123 phospholipase A2 group IB Homo sapiens 47-51 26855469-1 2016 After an hour contact with a phospholipase A2 (PLA2) solution, only the outer leaflet of the dipalmitoylphosphatidylcholine (DPPC) bilayers supported on mica surface underwent hydrolysis whose products, i.e., palmitic acid and lysophospholipid, accumulated on the bilayer surface. 1,2-Dipalmitoylphosphatidylcholine 125-129 phospholipase A2 group IB Homo sapiens 29-45 26855469-1 2016 After an hour contact with a phospholipase A2 (PLA2) solution, only the outer leaflet of the dipalmitoylphosphatidylcholine (DPPC) bilayers supported on mica surface underwent hydrolysis whose products, i.e., palmitic acid and lysophospholipid, accumulated on the bilayer surface. 1,2-Dipalmitoylphosphatidylcholine 125-129 phospholipase A2 group IB Homo sapiens 47-51 23727005-8 2013 Specifically, the rate of PLA2 hydrolysis of the coumarin labeled phosphatidylcholine analogs was less than three times slower than the natural substrate dipalmitoyl phosphatidylcholine (DPPC) under the same experimental conditions. 1,2-Dipalmitoylphosphatidylcholine 187-191 phospholipase A2 group IB Homo sapiens 26-30 20959114-0 2011 Kinetics of degradation of dipalmitoylphosphatidylcholine (DPPC) bilayers as a result of vipoxin phospholipase A2 activity: an atomic force microscopy (AFM) approach. 1,2-Dipalmitoylphosphatidylcholine 27-57 phospholipase A2 group IB Homo sapiens 97-113 21621398-0 2011 Changes in wetting properties of alumina surface treated with DPPC in the presence of phospholipase A2 enzyme. 1,2-Dipalmitoylphosphatidylcholine 62-66 phospholipase A2 group IB Homo sapiens 86-102 20959114-0 2011 Kinetics of degradation of dipalmitoylphosphatidylcholine (DPPC) bilayers as a result of vipoxin phospholipase A2 activity: an atomic force microscopy (AFM) approach. 1,2-Dipalmitoylphosphatidylcholine 59-63 phospholipase A2 group IB Homo sapiens 97-113 20441751-1 2010 We monitored the action of phospholipase A(2) (PLA(2)) on L- and D-dipalmitoyl-phosphatidylcholine (DPPC) Langmuir monolayers by mounting a Langmuir-trough on a wide-field fluorescence microscope with single molecule sensitivity. 1,2-Dipalmitoylphosphatidylcholine 100-104 phospholipase A2 group IB Homo sapiens 27-45 20441751-1 2010 We monitored the action of phospholipase A(2) (PLA(2)) on L- and D-dipalmitoyl-phosphatidylcholine (DPPC) Langmuir monolayers by mounting a Langmuir-trough on a wide-field fluorescence microscope with single molecule sensitivity. 1,2-Dipalmitoylphosphatidylcholine 100-104 phospholipase A2 group IB Homo sapiens 47-53 20441751-4 2010 Domains of gel state L-DPPC were degraded exclusively from the gel-fluid interface where the buildup of negatively charged hydrolysis products, fatty acid salts, led to changes in the mobility of PLA(2). 1,2-Dipalmitoylphosphatidylcholine 21-27 phospholipase A2 group IB Homo sapiens 196-202 11028030-0 2000 Dynamic Observations of the Hydrolysis of a DPPC Monolayer at the Air/Water Interface Catalyzed by Phospholipase A(2) This work was supported by the research contract between the German Max-Planck-Society and the Chinese Academy of Sciences as well as the National Natural Science Foundation of China (NNSF). 1,2-Dipalmitoylphosphatidylcholine 44-48 phospholipase A2 group IB Homo sapiens 99-116 18234820-3 2008 Activation of phospholipase A(2) (PLA(2)) by ternary model membranes with three components (DOPC/DPPC/Cholesterol) can potentially change the domain structure by preferential hydrolysis of the phospholipids. 1,2-Dipalmitoylphosphatidylcholine 97-101 phospholipase A2 group IB Homo sapiens 14-32 18234820-3 2008 Activation of phospholipase A(2) (PLA(2)) by ternary model membranes with three components (DOPC/DPPC/Cholesterol) can potentially change the domain structure by preferential hydrolysis of the phospholipids. 1,2-Dipalmitoylphosphatidylcholine 97-101 phospholipase A2 group IB Homo sapiens 34-40 15961786-4 2005 The present work studies the effect of AEA-induced structural modifications of the dipalmitoylphosphatidylcholine (DPPC) bilayer on phospholipase A2 (PLA2) activity, which is strictly dependent on lipid bilayer features. 1,2-Dipalmitoylphosphatidylcholine 83-113 phospholipase A2 group IB Homo sapiens 132-148 15961786-4 2005 The present work studies the effect of AEA-induced structural modifications of the dipalmitoylphosphatidylcholine (DPPC) bilayer on phospholipase A2 (PLA2) activity, which is strictly dependent on lipid bilayer features. 1,2-Dipalmitoylphosphatidylcholine 83-113 phospholipase A2 group IB Homo sapiens 150-154 15961786-4 2005 The present work studies the effect of AEA-induced structural modifications of the dipalmitoylphosphatidylcholine (DPPC) bilayer on phospholipase A2 (PLA2) activity, which is strictly dependent on lipid bilayer features. 1,2-Dipalmitoylphosphatidylcholine 115-119 phospholipase A2 group IB Homo sapiens 132-148 15961786-4 2005 The present work studies the effect of AEA-induced structural modifications of the dipalmitoylphosphatidylcholine (DPPC) bilayer on phospholipase A2 (PLA2) activity, which is strictly dependent on lipid bilayer features. 1,2-Dipalmitoylphosphatidylcholine 115-119 phospholipase A2 group IB Homo sapiens 150-154 15566157-5 2004 We demonstrated the hydrolysis reaction in DPPC (dipalmitoyl phosphatidylcholine)/DPPS (dipalmitoyl phosphatidylserine)-mixed monolayers by phospholipase A2 by using the system. 1,2-Dipalmitoylphosphatidylcholine 43-47 phospholipase A2 group IB Homo sapiens 140-156 15566157-5 2004 We demonstrated the hydrolysis reaction in DPPC (dipalmitoyl phosphatidylcholine)/DPPS (dipalmitoyl phosphatidylserine)-mixed monolayers by phospholipase A2 by using the system. 1,2-Dipalmitoylphosphatidylcholine 49-80 phospholipase A2 group IB Homo sapiens 140-156 11718669-0 2001 Phospholipase A(2) activity towards vesicles of DPPC and DMPC-DSPC containing small amounts of SMPC. 1,2-Dipalmitoylphosphatidylcholine 48-52 phospholipase A2 group IB Homo sapiens 0-18 11718669-2 2001 In this study the activity of PLA(2) towards large unilamellar vesicles composed of DPPC:SMPC and DMPC:DSPC:SMPC is investigated using fluorescence and HPLC techniques. 1,2-Dipalmitoylphosphatidylcholine 84-88 phospholipase A2 group IB Homo sapiens 30-36 11332933-5 2001 Therefore, the presence of PLA2 activity in meconium, collected from 10 newborns, was measured by the formation of lysophosphatidylcholine after incubation of meconium with radioactively labelled dipalmitoylphosphatidylcholine. 1,2-Dipalmitoylphosphatidylcholine 196-226 phospholipase A2 group IB Homo sapiens 27-31 20000434-4 2010 The enzyme PLA(2) hydrolyzes DPPC monolayers in the presence of a supersaturated calcium oxalate subphase, inducing the rapid and plentiful nucleation of calcium oxalate at the lipid interface. 1,2-Dipalmitoylphosphatidylcholine 29-33 phospholipase A2 group IB Homo sapiens 11-17 12672109-0 2003 Direct observations of the cleavage reaction of an L-DPPC monolayer catalyzed by phospholipase A2 and inhibited by an indole inhibitor at the air/water interface. 1,2-Dipalmitoylphosphatidylcholine 51-57 phospholipase A2 group IB Homo sapiens 81-97 12672109-1 2003 The enzymatic hydrolysis of an L-dipalmitoylphosphatidylcholine (L-DPPC) monolayer at the air/water interface, catalyzed by phospholipase A(2) (PLA(2)), serves as a model for biospecific interfacial reactions. 1,2-Dipalmitoylphosphatidylcholine 65-71 phospholipase A2 group IB Homo sapiens 124-142 12672109-1 2003 The enzymatic hydrolysis of an L-dipalmitoylphosphatidylcholine (L-DPPC) monolayer at the air/water interface, catalyzed by phospholipase A(2) (PLA(2)), serves as a model for biospecific interfacial reactions. 1,2-Dipalmitoylphosphatidylcholine 65-71 phospholipase A2 group IB Homo sapiens 144-150 11282244-9 2001 In conclusion, this study suggest that degradation of the lipid bilayer of PEG-liposomes by PLA(2) result in release of incapsulated drug, e.g. gentamicin and inclusion of PE in the liposomal bilayer, may enhance the activity of the mammalian sPLA(2) toward liposomes composed of DPPC. 1,2-Dipalmitoylphosphatidylcholine 280-284 phospholipase A2 group IB Homo sapiens 92-98 9591666-1 1998 We have investigated the time course of the degradation of a supported dipalmitoylphosphatidylcholine bilayer by phospholipase A2 in aqueous buffer with an atomic force microscope. 1,2-Dipalmitoylphosphatidylcholine 71-101 phospholipase A2 group IB Homo sapiens 113-129 10361145-3 1999 In this study, the blood clearance and the PLA2 catalyzed degradation of unilamellar dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with increasing amounts of dipalmitoylphosphatidylethanolamine-polyethyleneglycol (DPPE-PEG), was investigated. 1,2-Dipalmitoylphosphatidylcholine 85-115 phospholipase A2 group IB Homo sapiens 43-47 10361145-3 1999 In this study, the blood clearance and the PLA2 catalyzed degradation of unilamellar dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with increasing amounts of dipalmitoylphosphatidylethanolamine-polyethyleneglycol (DPPE-PEG), was investigated. 1,2-Dipalmitoylphosphatidylcholine 117-121 phospholipase A2 group IB Homo sapiens 43-47 10361147-4 1999 The temperature dependence of the PLA2 lag-time, denoting the time required before a sudden increase in enzymatic activity takes place, has been determined for submicellar amounts of dipalmitoylphosphatidylethanolaminyl-poly-(ethylene glycol) (DPPE-PEG2000) incorporated into unilamellar dipalmitoylphosphatidylcholine (DPPC)-liposomes. 1,2-Dipalmitoylphosphatidylcholine 288-318 phospholipase A2 group IB Homo sapiens 34-38 10361147-4 1999 The temperature dependence of the PLA2 lag-time, denoting the time required before a sudden increase in enzymatic activity takes place, has been determined for submicellar amounts of dipalmitoylphosphatidylethanolaminyl-poly-(ethylene glycol) (DPPE-PEG2000) incorporated into unilamellar dipalmitoylphosphatidylcholine (DPPC)-liposomes. 1,2-Dipalmitoylphosphatidylcholine 320-324 phospholipase A2 group IB Homo sapiens 34-38 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 48-78 phospholipase A2 group IB Homo sapiens 0-16 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 48-78 phospholipase A2 group IB Homo sapiens 18-22 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 80-84 phospholipase A2 group IB Homo sapiens 0-16 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 80-84 phospholipase A2 group IB Homo sapiens 18-22 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 303-307 phospholipase A2 group IB Homo sapiens 0-16 9733909-1 1998 Phospholipase A2 (PLA2)-catalyzed hydrolysis of dipalmitoylphosphatidylcholine (DPPC) liposomes incorporated with submicellar concentrations of polyethyleneoxide covalently attached to dipalmitoylphosphatidylethanolamine (DPPE-PEG2000) has been studied in the gel-to-fluid transition region of the host DPPC lipid bilayer matrix. 1,2-Dipalmitoylphosphatidylcholine 303-307 phospholipase A2 group IB Homo sapiens 18-22 9692961-0 1998 Definition of the specific roles of lysolecithin and palmitic acid in altering the susceptibility of dipalmitoylphosphatidylcholine bilayers to phospholipase A2. 1,2-Dipalmitoylphosphatidylcholine 101-131 phospholipase A2 group IB Homo sapiens 144-160 9576803-0 1998 Cascade liposomal triggering: light-induced Ca2+ release from diplasmenylcholine liposomes triggers PLA2-catalyzed hydrolysis and contents leakage from DPPC liposomes. 1,2-Dipalmitoylphosphatidylcholine 152-156 phospholipase A2 group IB Homo sapiens 100-104 9576803-10 1998 Bacteriochlorophyll (BChl)-sensitized photorelease of Ca2+ from PLA2-resistant DPPlsCho liposomes activates extravesicular PLA2, thereby promoting catalyzed DPPC hydrolysis in a secondary triggering reaction, leading to calcein release. 1,2-Dipalmitoylphosphatidylcholine 157-161 phospholipase A2 group IB Homo sapiens 64-68 9576803-10 1998 Bacteriochlorophyll (BChl)-sensitized photorelease of Ca2+ from PLA2-resistant DPPlsCho liposomes activates extravesicular PLA2, thereby promoting catalyzed DPPC hydrolysis in a secondary triggering reaction, leading to calcein release. 1,2-Dipalmitoylphosphatidylcholine 157-161 phospholipase A2 group IB Homo sapiens 123-127 9084505-0 1997 Surface properties after a simulated PLA2 hydrolysis of pulmonary surfactant"s main component, DPPC. 1,2-Dipalmitoylphosphatidylcholine 95-99 phospholipase A2 group IB Homo sapiens 37-41 9691465-3 1998 C6- and C8-ceramides increased the ordering of the DPPC acyl chains, correlating with the inhibition of PL-A2 activity which was probably due to the increased lateral surface pressure. 1,2-Dipalmitoylphosphatidylcholine 51-55 phospholipase A2 group IB Homo sapiens 104-109 8960386-6 1996 In both Survanta and DPPC preparations, PLA2-mediated deacylation was significantly inhibited in the presence of tyloxapol. 1,2-Dipalmitoylphosphatidylcholine 21-25 phospholipase A2 group IB Homo sapiens 40-44 9003195-2 1997 A slight perturbation was established in the outer leaflets of DPPC LUVs by hydrolyzing 0.8% of the outer leaflet lipid with phospholipase A2 to produce lysophosphatidylcholine and palmitate which were then removed by bovine serum albumin. 1,2-Dipalmitoylphosphatidylcholine 63-67 phospholipase A2 group IB Homo sapiens 125-141 8960386-7 1996 We conclude that the presence of tyloxapol in the Exosurf preparation inhibits secretory type PLA2 mediated DPPC deacylation. 1,2-Dipalmitoylphosphatidylcholine 108-112 phospholipase A2 group IB Homo sapiens 94-98 1854738-4 1991 A large [14C]carbonyl carbon isotope effect of 1.12 +/- 0.02 was measured for the cobra venom PLA2-catalyzed hydrolysis of dipalmitoylphosphatidylcholine in Triton X-100. 1,2-Dipalmitoylphosphatidylcholine 123-153 phospholipase A2 group IB Homo sapiens 94-98 8664287-0 1996 Relationships between bilayer structure and phospholipase A2 activity: interactions among temperature, diacylglycerol, lysolecithin, palmitic acid, and dipalmitoylphosphatidylcholine. 1,2-Dipalmitoylphosphatidylcholine 152-182 phospholipase A2 group IB Homo sapiens 44-60 7811738-0 1995 Hydrolysis of DMPC or DPPC by pancreatic phospholipase A2 is slowed down when (perfluoroalkyl) alkanes are incorporated into the liposomal membrane. 1,2-Dipalmitoylphosphatidylcholine 22-26 phospholipase A2 group IB Homo sapiens 41-57 8110807-1 1994 The modulation by gangliosides GM1 and GD1a, and sulfatide (Sulf) of the activity of porcine pancreatic phospholipase A2 was studied with small unilamellar vesicles of dipalmitoylphosphatidylcholine (L-dpPC) and lipid monolayers of dilauroylphosphatidylcholine (L-dlPC). 1,2-Dipalmitoylphosphatidylcholine 168-198 phospholipase A2 group IB Homo sapiens 104-120 1581331-11 1992 Introduction of fluorescence-labeled phospholipase A2 underneath these mixed domains results in rapid binding of the protein to the domains without visible hydrolytic activity, regardless of whether the L-form or the D-form of the DPPC were used. 1,2-Dipalmitoylphosphatidylcholine 231-235 phospholipase A2 group IB Homo sapiens 37-53 1581331-12 1992 In binary mixtures, only those with DPPC/palmitic acid show formation of phase-separated areas which can be specifically targeted by phospholipase A2 leading to a rapid formation (within 2 min) of protein domains. 1,2-Dipalmitoylphosphatidylcholine 36-40 phospholipase A2 group IB Homo sapiens 133-149 2334729-4 1990 DPPC solid phase domains were specifically targeted by phospholipase A2 and were observed to be hydrolyzed in a manner consistent with localized packing density differences. 1,2-Dipalmitoylphosphatidylcholine 0-4 phospholipase A2 group IB Homo sapiens 55-71 2115332-0 1990 Dipalmitoylphosphatidylcholine (L-alpha-lecithin) stimulates phospholipase A2 activity in human amnion. 1,2-Dipalmitoylphosphatidylcholine 0-30 phospholipase A2 group IB Homo sapiens 61-77 2115332-2 1990 Only PLA2 activity was increased by DPPC, suggesting that lecithin, the major surfactant component, increases the PGE production of the amniotic membrane by activating PLA2. 1,2-Dipalmitoylphosphatidylcholine 36-40 phospholipase A2 group IB Homo sapiens 5-9 2115332-2 1990 Only PLA2 activity was increased by DPPC, suggesting that lecithin, the major surfactant component, increases the PGE production of the amniotic membrane by activating PLA2. 1,2-Dipalmitoylphosphatidylcholine 36-40 phospholipase A2 group IB Homo sapiens 168-172 2344355-1 1990 The effects of tumour promoters, namely phorbol esters and teleocidin, on the activity of porcine pancreatic phospholipase A2 (PLA2) was investigated by using a system of small unilamellar vesicles composed of dipalmitoyl-phosphatidylcholine (DPPC). 1,2-Dipalmitoylphosphatidylcholine 210-241 phospholipase A2 group IB Homo sapiens 109-125 2344355-1 1990 The effects of tumour promoters, namely phorbol esters and teleocidin, on the activity of porcine pancreatic phospholipase A2 (PLA2) was investigated by using a system of small unilamellar vesicles composed of dipalmitoyl-phosphatidylcholine (DPPC). 1,2-Dipalmitoylphosphatidylcholine 210-241 phospholipase A2 group IB Homo sapiens 127-131 2344355-1 1990 The effects of tumour promoters, namely phorbol esters and teleocidin, on the activity of porcine pancreatic phospholipase A2 (PLA2) was investigated by using a system of small unilamellar vesicles composed of dipalmitoyl-phosphatidylcholine (DPPC). 1,2-Dipalmitoylphosphatidylcholine 243-247 phospholipase A2 group IB Homo sapiens 109-125 2344355-1 1990 The effects of tumour promoters, namely phorbol esters and teleocidin, on the activity of porcine pancreatic phospholipase A2 (PLA2) was investigated by using a system of small unilamellar vesicles composed of dipalmitoyl-phosphatidylcholine (DPPC). 1,2-Dipalmitoylphosphatidylcholine 243-247 phospholipase A2 group IB Homo sapiens 127-131 2344355-3 1990 The addition of PLA2 to Quin 2/DPPC vesicles increased the fluorescence intensity of Quin 2. 1,2-Dipalmitoylphosphatidylcholine 31-35 phospholipase A2 group IB Homo sapiens 16-20 2156930-6 1990 The results demonstrate that LPS stimulates phospholipase A2 activity and the hydrolysis of both 1,2-dipalmitoyl phosphatidylcholine and 1-steroyl 2-arachidonoyl phosphatidylcholine. 1,2-Dipalmitoylphosphatidylcholine 97-132 phospholipase A2 group IB Homo sapiens 44-60 2494377-1 1989 Apo C1, a 6.5 kD protein component of VLDL, inhibits the hydrolysis of DPPC vesicles by pancreatic PLA2 and the hydrolysis of cellular phospholipids by endogenous phospholipases by interaction with the substrate. 1,2-Dipalmitoylphosphatidylcholine 71-75 phospholipase A2 group IB Homo sapiens 99-103 3403556-10 1988 The effect of [PLA2] and [PC] on the hydrolysis reaction is similar to that found with pure DPPC unilamellar vesicles in their thermotropic phase transition region. 1,2-Dipalmitoylphosphatidylcholine 92-96 phospholipase A2 group IB Homo sapiens 15-19 3672025-1 1987 An assay using 2-(1-14C)palmitoyl-labelled dipalmitoyl phosphatidylcholine substrate for the determination of serum phospholipase A2 (PLA2) activity is described and validated. 1,2-Dipalmitoylphosphatidylcholine 43-74 phospholipase A2 group IB Homo sapiens 116-132 3124835-4 1988 At 1 mM 2-thioPC increasing the concentration of Triton X-100 from 4 to 16 mM changes the specific activity of bee-venom phospholipase A2 from 96.9 to 17.9 mumol/min/mg, about one order of magnitude lower than dipalmitoyl phosphatidylcholine hydrolysis in micelles of similar composition. 1,2-Dipalmitoylphosphatidylcholine 210-241 phospholipase A2 group IB Homo sapiens 121-137 3654625-0 1987 The activation of porcine pancreatic phospholipase A2 by dipalmitoylphosphatidylcholine large unilamellar vesicles. 1,2-Dipalmitoylphosphatidylcholine 57-87 phospholipase A2 group IB Homo sapiens 37-53 3654625-2 1987 Previous work from this laboratory and others has shown that the hydrolysis of pure dipalmitoylphosphatidylcholine (DPPC) liposomes by porcine pancreatic phospholipase A2 in the vicinity of the gel-to-liquid crystal phase transition is characterized by a slow initial phase followed by an apparent burst of activity. 1,2-Dipalmitoylphosphatidylcholine 84-114 phospholipase A2 group IB Homo sapiens 154-170 3654625-2 1987 Previous work from this laboratory and others has shown that the hydrolysis of pure dipalmitoylphosphatidylcholine (DPPC) liposomes by porcine pancreatic phospholipase A2 in the vicinity of the gel-to-liquid crystal phase transition is characterized by a slow initial phase followed by an apparent burst of activity. 1,2-Dipalmitoylphosphatidylcholine 116-120 phospholipase A2 group IB Homo sapiens 154-170 3672025-1 1987 An assay using 2-(1-14C)palmitoyl-labelled dipalmitoyl phosphatidylcholine substrate for the determination of serum phospholipase A2 (PLA2) activity is described and validated. 1,2-Dipalmitoylphosphatidylcholine 43-74 phospholipase A2 group IB Homo sapiens 134-138 3348816-0 1988 Induction of a latency period in the time-course of phospholipase A2 action on dipalmitoylphosphatidylcholine liposomes in the gel phase. 1,2-Dipalmitoylphosphatidylcholine 79-109 phospholipase A2 group IB Homo sapiens 52-68 3348816-1 1988 The hydrolysis of dipalmitoylphosphatidylcholine liposomes by porcine pancreatic phospholipase A2 was studied at 31 degrees C, i.e., with the substrate in the gel phase. 1,2-Dipalmitoylphosphatidylcholine 18-48 phospholipase A2 group IB Homo sapiens 81-97 3250632-1 1988 Membrane fluidity and osmotic sensitivity were examined in DPPC liposomes treated with phospholipase A2 (PL.A2) in the presence of Ca2+ or Mg2+. 1,2-Dipalmitoylphosphatidylcholine 59-63 phospholipase A2 group IB Homo sapiens 87-103 3250632-1 1988 Membrane fluidity and osmotic sensitivity were examined in DPPC liposomes treated with phospholipase A2 (PL.A2) in the presence of Ca2+ or Mg2+. 1,2-Dipalmitoylphosphatidylcholine 59-63 phospholipase A2 group IB Homo sapiens 105-110 3566802-3 1987 In the present experiments, the influence of the amphiphilic drugs ambroxol, imipramine, chloroquine and chlorphentermine on the hydrolysis of dipalmitoyl-phosphatidylcholine (DPPC) unilamellar liposomes by bee venom phospholipase A2 (PLase A2) was studied. 1,2-Dipalmitoylphosphatidylcholine 143-174 phospholipase A2 group IB Homo sapiens 217-233 3566802-3 1987 In the present experiments, the influence of the amphiphilic drugs ambroxol, imipramine, chloroquine and chlorphentermine on the hydrolysis of dipalmitoyl-phosphatidylcholine (DPPC) unilamellar liposomes by bee venom phospholipase A2 (PLase A2) was studied. 1,2-Dipalmitoylphosphatidylcholine 143-174 phospholipase A2 group IB Homo sapiens 235-243 6689106-2 1983 Glycyrrhizin was found to inhibit the PLA2-induced carboxyfluorescein (CF) release from D,L-dipalmitoyl phosphatidylcholine (DPPC) liposomes. 1,2-Dipalmitoylphosphatidylcholine 125-129 phospholipase A2 group IB Homo sapiens 38-42 3754257-0 1986 Hydrolysis of dipalmitoylphosphatidylcholine small unilamellar vesicles by porcine pancreatic phospholipase A2. 1,2-Dipalmitoylphosphatidylcholine 14-44 phospholipase A2 group IB Homo sapiens 94-110 3754257-9 1986 These results lead us to conclude that two distinctly different steps precede rapid hydrolysis of dipalmitoylphosphatidylcholine small unilamellar vesicles by pancreatic phospholipase A2: a Ca2+-independent binding of the enzyme to the substrate vesicles, which for chemically pure bilayers occurs best in the gel phase. 1,2-Dipalmitoylphosphatidylcholine 98-128 phospholipase A2 group IB Homo sapiens 170-186 3754258-0 1986 Hydrolysis of dipalmitoylphosphatidylcholine large unilamellar vesicles by porcine pancreatic phospholipase A2. 1,2-Dipalmitoylphosphatidylcholine 14-44 phospholipase A2 group IB Homo sapiens 94-110 3754258-1 1986 The interaction between dipalmitoylphosphatidylcholine large unilamellar vesicles and porcine pancreatic phospholipase A2 has been studied under a variety of conditions. 1,2-Dipalmitoylphosphatidylcholine 24-54 phospholipase A2 group IB Homo sapiens 105-121 3997864-4 1985 For a given concentration of manoalide, the inhibition of phospholipase A2 activity toward dipalmitoylphosphatidylcholine/Triton X-100 mixed micelles is time-dependent and plateaus at about 85% inhibition of the initial velocity even after extensive preincubation. 1,2-Dipalmitoylphosphatidylcholine 91-121 phospholipase A2 group IB Homo sapiens 58-74 3919022-6 1985 Hydrolysis of multilamellar dipalmitoylphosphatidylcholine liposomes by purified phospholipase A2, was also inhibited by CRP. 1,2-Dipalmitoylphosphatidylcholine 28-58 phospholipase A2 group IB Homo sapiens 81-97 6546725-1 1984 The hydrolytic action of porcine pancreatic phospholipase A2 (PLA2) on cholesterol-containing dipalmitoylphosphatidylcholine liposomes was studied under various osmotic conditions by means of the phase transition release (PTR) technique. 1,2-Dipalmitoylphosphatidylcholine 94-124 phospholipase A2 group IB Homo sapiens 44-60 6546725-1 1984 The hydrolytic action of porcine pancreatic phospholipase A2 (PLA2) on cholesterol-containing dipalmitoylphosphatidylcholine liposomes was studied under various osmotic conditions by means of the phase transition release (PTR) technique. 1,2-Dipalmitoylphosphatidylcholine 94-124 phospholipase A2 group IB Homo sapiens 62-66 6689106-3 1983 Part of this inhibitory effect of glycyrrhizin on PLA2 is accounted for by the physical state of the substrate, the DPPC liposome membrane. 1,2-Dipalmitoylphosphatidylcholine 116-120 phospholipase A2 group IB Homo sapiens 50-54 582173-0 1979 Action of cobra venom phospholipase A2 on the gel and liquid crystalline states of dimyristoyl and dipalmitoyl phosphatidylcholine vesicles. 1,2-Dipalmitoylphosphatidylcholine 99-130 phospholipase A2 group IB Homo sapiens 22-38