PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19047162-0	2008	Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.	Eflornithine	38-67	cyclin dependent kinase inhibitor 1B	Homo sapiens	159-166	
19047162-6	2008	Intriguingly, DFMO also induced the phosphorylation of p27Kip1 at residues Ser10 (nuclear export) and Thr198 (protein stabilization) but not Thr187 (proteasomal degradation).	Eflornithine	14-18	cyclin dependent kinase inhibitor 1B	Homo sapiens	55-62	
19047162-8	2008	The data suggest that inhibition of ODC by DFMO induces two opposing pathways in NB: one promoting cell survival by activating Akt/PKB via the PI3K/Akt pathway and one inducing p27Kip1/retinoblastoma-coupled G1 cell cycle arrest via a mechanism that regulates the phosphorylation and stabilization of p27Kip1.	Eflornithine	43-47	cyclin dependent kinase inhibitor 1B	Homo sapiens	177-184	
19047162-8	2008	The data suggest that inhibition of ODC by DFMO induces two opposing pathways in NB: one promoting cell survival by activating Akt/PKB via the PI3K/Akt pathway and one inducing p27Kip1/retinoblastoma-coupled G1 cell cycle arrest via a mechanism that regulates the phosphorylation and stabilization of p27Kip1.	Eflornithine	43-47	cyclin dependent kinase inhibitor 1B	Homo sapiens	301-308	
10654447-6	2000	The p27Kip1, level was increased by dexamethasone or and DFMO in line with the kinetics of G1 arrest.	Eflornithine	57-61	cyclin dependent kinase inhibitor 1B	Homo sapiens	4-11	
16007177-11	2005	We show for the first time that DFMO and SAM486A induce G1 cell cycle arrest in NB cells through p27Kip1 and Rb hypophosphorylation.	Eflornithine	32-36	cyclin dependent kinase inhibitor 1B	Homo sapiens	97-104	
23440295-0	2013	DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.	Eflornithine	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	82-89	
23440295-0	2013	DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.	Eflornithine	5-17	cyclin dependent kinase inhibitor 1B	Homo sapiens	82-89	
23440295-5	2013	DFMO treatment leads to the accumulation of the cyclin-dependent kinase inhibitor p27(Kip1) protein and causes p27(Kip1)/Rb-coupled G(1) cell cycle arrest in MYCN-amplified NB tumor cells through a process that involves p27(Kip1) phosphorylation at residues Ser10 and Thr198.	Eflornithine	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	86-90	
23440295-5	2013	DFMO treatment leads to the accumulation of the cyclin-dependent kinase inhibitor p27(Kip1) protein and causes p27(Kip1)/Rb-coupled G(1) cell cycle arrest in MYCN-amplified NB tumor cells through a process that involves p27(Kip1) phosphorylation at residues Ser10 and Thr198.	Eflornithine	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	115-119	
23440295-5	2013	DFMO treatment leads to the accumulation of the cyclin-dependent kinase inhibitor p27(Kip1) protein and causes p27(Kip1)/Rb-coupled G(1) cell cycle arrest in MYCN-amplified NB tumor cells through a process that involves p27(Kip1) phosphorylation at residues Ser10 and Thr198.	Eflornithine	0-4	cyclin dependent kinase inhibitor 1B	Homo sapiens	115-119