PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15860639-7 2005 Further examination showed that DFMO pretreatment inhibited the radiation-induced increase in the proapoptotic protein Bax. Eflornithine 32-36 BCL2 associated X, apoptosis regulator Rattus norvegicus 119-122 15860639-9 2005 We conclude that polyamine depletion by DFMO inhibits gamma-irradiation-induced apoptosis of intestinal epithelial cells both in vitro and in vivo through inhibition of Bax and caspase-3 activity, which leads to attenuation of radiation-inflicted intestinal injury. Eflornithine 40-44 BCL2 associated X, apoptosis regulator Rattus norvegicus 169-172 11303587-9 2001 Importantly, DFMO-treated ZD esophagi display increased rate of apoptosis accompanied by intense bax expression and greatly reduced cell proliferation by proliferating cell nuclear antigen expression. Eflornithine 13-17 BCL2 associated X, apoptosis regulator Rattus norvegicus 97-100 27074051-12 2016 DFMO down-regulated the expression of ODC, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), cleaved caspase-12, and Bax and up-regulated the expression of SSAT and Bcl-2. Eflornithine 0-4 BCL2 associated X, apoptosis regulator Rattus norvegicus 138-141 9850069-11 1998 In addition, the expression of bax protein, an apoptosis accelerator, was markedly stronger in esophagi from Zn-/DFMO+ animals that showed increased apoptosis, whereas increased expression of bcl-2, an inhibitor of apoptosis, was only seen in the highly proliferative, zinc-deficient esophagus (Zn-/DFMO-). Eflornithine 113-117 BCL2 associated X, apoptosis regulator Rattus norvegicus 31-34 9850069-11 1998 In addition, the expression of bax protein, an apoptosis accelerator, was markedly stronger in esophagi from Zn-/DFMO+ animals that showed increased apoptosis, whereas increased expression of bcl-2, an inhibitor of apoptosis, was only seen in the highly proliferative, zinc-deficient esophagus (Zn-/DFMO-). Eflornithine 299-303 BCL2 associated X, apoptosis regulator Rattus norvegicus 31-34 25323967-12 2014 In addition, DFMO (0.5 mM) down regulated the expression of ODC, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), cleaved caspase-12, and Bax and up regulated the expression of SSAT and Bcl-2. Eflornithine 13-17 BCL2 associated X, apoptosis regulator Rattus norvegicus 160-163