PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20154224-8 2010 Real-time quantitative RT-PCR results demonstrated that, at 4-8 h, bleomycin induced expression of TNF and TNF receptor family genes known to induce the extrinsic apoptotic pathway. Bleomycin 67-76 tumor necrosis factor Homo sapiens 99-102 20154224-8 2010 Real-time quantitative RT-PCR results demonstrated that, at 4-8 h, bleomycin induced expression of TNF and TNF receptor family genes known to induce the extrinsic apoptotic pathway. Bleomycin 67-76 tumor necrosis factor Homo sapiens 107-110 15964043-3 2006 The THP1 human monocytic cell line, which constitutively expresses high levels of TLR2, secretes interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha during bleomycin exposure. Bleomycin 172-181 tumor necrosis factor Homo sapiens 131-164 15195196-7 2004 Drug-induced pulmonary fibrosis may involve release of free oxygen radicals and various cytokines for example IL-Ibeta and TNF-alpha via activation of nuclear transcription factor NF-beta as in the case of bleomycin and mitomycin or via release of TGF-beta as in case of tamoxifen or via inhibition of macrophages" and lymphocytes" phospholipases as in the case of amiodarone with the resultant accumulation of phospholipids and reduction of the immune system. Bleomycin 206-215 tumor necrosis factor Homo sapiens 123-132 14617519-6 2004 2) In the presence of bleomycin, ozone-induced oxidation significantly decreased the ability of 1A and 1A/6A(4), but not of 6A(4), to stimulate TNF-alpha production. Bleomycin 22-31 tumor necrosis factor Homo sapiens 144-153 12816730-10 2003 In addition, recombinant human TNF-alpha attenuated bleomycin-induced pulmonary fibrosis. Bleomycin 52-61 tumor necrosis factor Homo sapiens 31-40 12496444-2 2003 As a potent proinflammatory cytokine, TNF has been suggested to play critical roles in the pathogenesis of the human disease and its animal model, bleomycin-induced pneumopathy. Bleomycin 147-156 tumor necrosis factor Homo sapiens 38-41 12060565-4 2002 1) Bleomycin-treated THP-1 cells increased tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, and IL-1beta production in dose- and time-dependent patterns, as we have observed with SP-A. Bleomycin 3-12 tumor necrosis factor Homo sapiens 43-76 10090171-8 1999 The cellular release of IL-1beta, TNF-alpha, and IL-6 was elevated in response to bleomycin exposure in both controls and patients with SSc. Bleomycin 82-91 tumor necrosis factor Homo sapiens 34-43 9486589-0 1998 Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity. Bleomycin 55-64 tumor necrosis factor Homo sapiens 13-40 9486589-5 1998 RESULTS: Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. Bleomycin 112-121 tumor necrosis factor Homo sapiens 47-56 9486589-7 1998 CONCLUSIONS: The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. Bleomycin 63-72 tumor necrosis factor Homo sapiens 29-38 9486589-7 1998 CONCLUSIONS: The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. Bleomycin 191-200 tumor necrosis factor Homo sapiens 29-38 7516893-0 1994 Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Bleomycin 85-94 tumor necrosis factor Homo sapiens 39-42 7516893-3 1994 Infusion of a 55 kD human recombinant soluble TNF receptor rsTNFR-beta, at a rate of 20 micrograms.day-1, prevented the bleomycin/silica induced increase of lung hydroxyproline content, as measured 15 days after instillation. Bleomycin 120-129 tumor necrosis factor Homo sapiens 46-49 8317554-7 1993 Enzyme induction with paraquat, adriamycin, or bleomycin was inhibitable by neutralizing antibody to interleukin-1 and tumor necrosis factor, suggesting that the inductions observed with these three drugs are due to the distal mediators, interleukin-1 or tumor necrosis factor released from the cells. Bleomycin 47-56 tumor necrosis factor Homo sapiens 119-140 1414690-1 1992 Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. Bleomycin 97-106 tumor necrosis factor Homo sapiens 25-46 1414690-1 1992 Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. Bleomycin 97-106 tumor necrosis factor Homo sapiens 48-51 34783198-0 2021 MicroRNA-411-3p inhibits bleomycin-induced skin fibrosis by regulating transforming growth factor-beta/Smad ubiquitin regulatory factor-2 signalling. Bleomycin 25-34 tumor necrosis factor Homo sapiens 71-102 34220507-8 2021 Significantly, our results showed that Myricetin has potent effect on bleomycin-induced pulmonary inflammation by inhibiting the infiltration of inflammatory cells and the secretion of inflammatory cytokines IL-6, IL-1alpha, TNF-alpha and IFN-gamma. Bleomycin 70-79 tumor necrosis factor Homo sapiens 225-234 32521909-1 2020 PURPOSE: To investigate the influence of bleomycin (BLM) on the proliferation and apoptosis of brain glioma cells through transforming growth factor-beta (TGF-beta)/Smads signaling pathway. Bleomycin 41-50 tumor necrosis factor Homo sapiens 122-153 28731277-0 2018 TNF-alpha-induced NF-kappaB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis. Bleomycin 105-114 tumor necrosis factor Homo sapiens 0-9 28731277-4 2018 In this study, we found that the pro-inflammatory cytokine TNF-alpha and the transcription factor nuclear factor kappa B (NF-kappaB) p65 subunit were both upregulated in bleomycin-induced fibrotic lung tissue. Bleomycin 170-179 tumor necrosis factor Homo sapiens 59-68 29670467-2 2018 In the present study, the expression of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) was key to the resolution of bleomycin-induced pulmonary fibrosis. Bleomycin 141-150 tumor necrosis factor Homo sapiens 40-103 29348392-4 2018 The senescence-associated beta-galactosidase activity, the protein expression of P16 and P21, and inflammatory-related marker gene levels IL-1beta, IL-6, and TNF-alpha were increased in bleomycin-treated AFSCs in a dose-dependent manner. Bleomycin 186-195 tumor necrosis factor Homo sapiens 158-167 29348392-5 2018 Rapamycin treatment decreased the gene expression of MMP-3, MMP-13, IL-1beta, IL-6, TNF-alpha, and protein levels of P16 and P21 in bleomycin-treated AFSCs. Bleomycin 132-141 tumor necrosis factor Homo sapiens 84-93 27317685-7 2016 Bleomycin-induced increases in tissue neutrophils and macrophages and lung contents of LTB4 and tumor necrosis factor-alpha were all prevented by treatment with zileuton. Bleomycin 0-9 tumor necrosis factor Homo sapiens 87-123