PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22521291-13	2012	SIGNIFICANCE: Ouabain significantly stimulated atrial ANP secretion via an ET-1-ET(B) receptor-mediated pathway involving MAPK signaling pathway activation and prostaglandin formation.	Prostaglandins	160-173	endothelin-1	Oryctolagus cuniculus	75-79	
16612843-9	2006	In summary, diabetes decreases the sensitivity of the rabbit renal artery to endothelin-1 by decreasing the ratio between vasoconstrictor and vasodilator prostanoids released after activation of endothelin ET(A) receptors.	Prostaglandins	154-165	endothelin-1	Oryctolagus cuniculus	77-89	
19128383-1	2008	PURPOSE: To determine whether a topically instilled prostaglandin analogue inhibits endothelin-1 (ET-1)-induced vasoconstrictive effects in the posterior retina by its local effects, and the duration of the effect in normal rabbit eyes.	Prostaglandins	52-65	endothelin-1	Oryctolagus cuniculus	84-96	
19128383-1	2008	PURPOSE: To determine whether a topically instilled prostaglandin analogue inhibits endothelin-1 (ET-1)-induced vasoconstrictive effects in the posterior retina by its local effects, and the duration of the effect in normal rabbit eyes.	Prostaglandins	52-65	endothelin-1	Oryctolagus cuniculus	98-102	
19128383-7	2008	CONCLUSIONS: After a 7-day instillation in normal rabbit eyes, topical travoprost suppressed ET-1-induced vasoconstrictive effects only in the ipsilateral posterior retina by its local effect; this effect was maintained at least for 30 min and mediated by endogenous prostaglandins.	Prostaglandins	267-281	endothelin-1	Oryctolagus cuniculus	93-97	
17552879-0	2008	Nitric oxide and prostaglandins - important players in endothelin-1 induced myocardial distensibility.	Prostaglandins	17-31	endothelin-1	Oryctolagus cuniculus	55-67	
10214485-7	1999	The results indicated that there might have been an interaction between Endothelin-1 and the prostaglandin synthesis mechanism in acute cerebral vasoconstriction.	Prostaglandins	93-106	endothelin-1	Oryctolagus cuniculus	72-84	
9086738-5	1997	Treatment with anti-prostaglandin agents before and after the injection blocked APC increase completely in the 10(-5)M ET-1 model, and partially in the 10(-4)M ET-1 model.	Prostaglandins	20-33	endothelin-1	Oryctolagus cuniculus	119-123	
9086738-5	1997	Treatment with anti-prostaglandin agents before and after the injection blocked APC increase completely in the 10(-5)M ET-1 model, and partially in the 10(-4)M ET-1 model.	Prostaglandins	20-33	endothelin-1	Oryctolagus cuniculus	160-164	
8739497-0	1996	Effects of BQ-123, an ETA recepter-selective antagonist, on changes of intraocular pressure, blood-aqueous barrier and aqueous prostaglandin concentrations caused by endothelin-1 in rabbit.	Prostaglandins	127-140	endothelin-1	Oryctolagus cuniculus	166-178	
8365455-6	1993	These results confirm our previous observations suggesting that pressor responses and prostanoid release induced by endothelin-1 are mediated via the selective activation of ETA receptors in the perfused rabbit kidney.	Prostaglandins	86-96	endothelin-1	Oryctolagus cuniculus	116-128	
7692176-3	1993	Furthermore, the increase in resting CPP induced by graded doses of endothelin-1 (ET-1 0.6-160 pmol), was further augmented by blocking of prostaglandin biosynthesis with indomethacin (3 microM) and was substantially reduced when the rate of formation of PGI2 was enhanced by defibrotide (200 micrograms/ml).	Prostaglandins	139-152	endothelin-1	Oryctolagus cuniculus	68-80	
1326745-5	1992	ET-1-induced Cl- secretion is completely inhibited by the loop diuretic bumetanide and by indomethacin and quinacrine, inhibitors of prostaglandin synthesis.	Prostaglandins	133-146	endothelin-1	Oryctolagus cuniculus	0-4	
1398887-5	1992	A metalloprotease inhibitor, phosphoramidon (100 microM, 60 minutes), reduced the prostanoid release and pressor responses induced by big endothelin-1 and -2 without affecting the response induced by endothelin-1, -2, and -3.	Prostaglandins	82-92	endothelin-1	Oryctolagus cuniculus	138-157	
1326745-8	1992	It is concluded that ET-1 causes Cl- and K+ secretion by stimulating phospholipase A2 and release of prostaglandins, whereas Na+ transport is not altered.	Prostaglandins	101-115	endothelin-1	Oryctolagus cuniculus	21-25	
2058688-8	1991	Collectively, these findings demonstrate that ET-1 exerts a potent duality of action in rabbit TSM which varies significantly with maturation, wherein 1) age-dependent differences in airway relaxation are associated with changes in the evoked release of bronchodilatory prostaglandins and 2) maturational differences in airway contraction are associated with changes in Ins(1,4,5)P3 accumulation and extracellular Ca2+ mobilization, coupled to differences in PKC activation.	Prostaglandins	270-284	endothelin-1	Oryctolagus cuniculus	46-50	
1904341-0	1991	Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in rabbit iris sphincter smooth muscle: activation of phospholipase A2.	Prostaglandins	60-74	endothelin-1	Oryctolagus cuniculus	0-12