PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21865589-2 2011 The final metabolite of PGs 15-deoxy-delta-12,14-PGJ(2) (15-deoxy-delta PGJ(2)) is the endogenous ligand of the peroxisome proliferator-activated receptor (PPAR) gamma. Prostaglandins 24-27 peroxisome proliferator activated receptor gamma Mus musculus 112-167 21444150-4 2011 Since these effects could be mediated through AKR1C3-catalyzed reductions of the PPARgamma ligand, 15-DeoxyDelta(12,14)-PGJ(2), we treated the cells with prostaglandins (PG). Prostaglandins 154-168 peroxisome proliferator activated receptor gamma Mus musculus 81-90 21651978-7 2011 Using stimulated macrophages from Nrf2-deficient mice or activators of Nrf2 and PPARgamma, we found that Nrf2, but not PPARgamma, is involved in the PG-dependent increase in Prx 6 mRNA expression. Prostaglandins 149-151 peroxisome proliferator activated receptor gamma Mus musculus 80-89 11927655-1 2002 The prostaglandin, 15-deoxy Delta(12,14)-prostaglandin J2 (15d-PGJ2)(1), and thiazolidinediones are ligands for the nuclear receptor, peroxisome proliferator-activated receptor (PPAR)-gamma, which mediates anti-inflammatory activity by suppressing murine macrophage (Mphi) production of the inflammatory mediator, nitric oxide (NO). Prostaglandins 4-17 peroxisome proliferator activated receptor gamma Mus musculus 134-189 15190061-2 2004 Ligands for PPARgamma include some polyunsaturated fatty acids and prostanoids and the synthetic high affinity antidiabetic agents thiazolidinediones. Prostaglandins 67-78 peroxisome proliferator activated receptor gamma Mus musculus 12-21 12611492-9 2003 These data reveal the potential for de novo 15-d-PGJ2 synthesis in the context of PPARgamma expression, suggesting that this prostaglandin may contribute to PPARgamma signalling in vivo. Prostaglandins 125-138 peroxisome proliferator activated receptor gamma Mus musculus 82-91 12611492-9 2003 These data reveal the potential for de novo 15-d-PGJ2 synthesis in the context of PPARgamma expression, suggesting that this prostaglandin may contribute to PPARgamma signalling in vivo. Prostaglandins 125-138 peroxisome proliferator activated receptor gamma Mus musculus 157-166 31630176-8 2020 Although several prostaglandin (PG) derivatives are known to be ligands for PPARgamma, treatment with a COX inhibitor, acetyl salicylic acid, upregulated the IgE-mediated increase of Il13, Tnf, and Ptgs2 mRNA levels in a synergistic manner with PPARgamma siRNA. Prostaglandins 17-30 peroxisome proliferator activated receptor gamma Mus musculus 76-85 11237557-2 2001 J series prostaglandins (PG) and thiazolidinediones block LPS stimulation of NO production via the activation of peroxisome proliferator-activator receptor-gamma (PPAR-gamma) in macrophages but utilize an alternative mechanism in microglial cells. Prostaglandins 9-23 peroxisome proliferator activated receptor gamma Mus musculus 113-161 11237557-2 2001 J series prostaglandins (PG) and thiazolidinediones block LPS stimulation of NO production via the activation of peroxisome proliferator-activator receptor-gamma (PPAR-gamma) in macrophages but utilize an alternative mechanism in microglial cells. Prostaglandins 9-23 peroxisome proliferator activated receptor gamma Mus musculus 163-173 11237557-2 2001 J series prostaglandins (PG) and thiazolidinediones block LPS stimulation of NO production via the activation of peroxisome proliferator-activator receptor-gamma (PPAR-gamma) in macrophages but utilize an alternative mechanism in microglial cells. Prostaglandins 25-27 peroxisome proliferator activated receptor gamma Mus musculus 113-161 11237557-2 2001 J series prostaglandins (PG) and thiazolidinediones block LPS stimulation of NO production via the activation of peroxisome proliferator-activator receptor-gamma (PPAR-gamma) in macrophages but utilize an alternative mechanism in microglial cells. Prostaglandins 25-27 peroxisome proliferator activated receptor gamma Mus musculus 163-173 9734399-4 1998 Therefore, the peroxisome proliferator-activated receptor gamma (PPARgamma), a downstream transcriptional mediator for prostaglandins and fatty acids which is highly expressed in the colon may be involved in this process. Prostaglandins 119-133 peroxisome proliferator activated receptor gamma Mus musculus 15-63 9734399-4 1998 Therefore, the peroxisome proliferator-activated receptor gamma (PPARgamma), a downstream transcriptional mediator for prostaglandins and fatty acids which is highly expressed in the colon may be involved in this process. Prostaglandins 119-133 peroxisome proliferator activated receptor gamma Mus musculus 65-74 35135573-12 2022 Abnormal lipid accumulation, changes of gene expression profile and upregulation of multi-component mechanistic target of rapamycin complex 1 (mTOR)/Peroxisome proliferator-activated receptor-gamma pathway was observed in liver, accompanied with decreased bile acids level, unsaturated fatty acids androgens and prostaglandins in serum. Prostaglandins 312-326 peroxisome proliferator activated receptor gamma Mus musculus 149-197 10926831-3 2000 PPARgamma, which is activated by specific prostanoids, is a key factor in activating terminal differentiation and adipogenesis. Prostaglandins 42-53 peroxisome proliferator activated receptor gamma Mus musculus 0-9 10868955-8 2000 These findings indicate that the PPAR-gamma agonists, troglitazone and the J series of prostaglandins, are potent anti-inflammatory agents that prevent cytokine- and endotoxin-stimulated activation of peripheral and resident tissue macrophages and cytokine-induced iNOS expression by beta-cells by the inhibition of transcriptional activation and induction of the heat shock response. Prostaglandins 87-101 peroxisome proliferator activated receptor gamma Mus musculus 33-43 33220278-4 2021 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandins 61-64 peroxisome proliferator activated receptor gamma Mus musculus 278-326 33220278-4 2021 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandins 61-64 peroxisome proliferator activated receptor gamma Mus musculus 328-337 31630176-8 2020 Although several prostaglandin (PG) derivatives are known to be ligands for PPARgamma, treatment with a COX inhibitor, acetyl salicylic acid, upregulated the IgE-mediated increase of Il13, Tnf, and Ptgs2 mRNA levels in a synergistic manner with PPARgamma siRNA. Prostaglandins 32-34 peroxisome proliferator activated receptor gamma Mus musculus 76-85 30400642-5 2018 Results showed that TZD drug, ciglitazone and natural ligand of PPARgamma 15d-prostaglandin downregulated Foxp3 expression in activated nTreg cells from both NOD and NOR mice. Prostaglandins 78-91 peroxisome proliferator activated receptor gamma Mus musculus 64-73